Hydrochloric Acid

Hydrochloric Acid

SCHEMBL183500

Cl.N=C(N)Cc1ccccc1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3E known ✓ A5X5Y0 1/20 0.55
HTR3B known ✓ O95264 1/20 0.55
HTR3A known ✓ P46098 1/20 0.55
HTR3D known ✓ Q70Z44 1/20 0.55
HTR3C known ✓ Q8WXA8 1/20 0.55
GRIN2D known ✓ O15399 1/20 0.47
GRIN3B known ✓ O60391 1/20 0.47
GRIN1 known ✓ Q05586 1/20 0.47
GRIN2A known ✓ Q12879 1/20 0.47
GRIN2B known ✓ Q13224 1/20 0.47
GRIN2C known ✓ Q14957 1/20 0.47
GRIN3A known ✓ Q8TCU5 1/20 0.47
IDO1 P14902 3/20 0.56
NOS1 P29475 3/20 0.52
NOS3 P29474 1/20 0.52
NOS2 P35228 1/20 0.52
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
BLM P54132 1/20 0.48
AKR1B1 P15121 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1238345 0.97 HTR3E (0.57) IDO1HTR3EHTR3BHTR3AHTR3D
Bicarbonate SCHEMBL6989215 0.91 CES1 (0.56) IDO1HTR3EHTR3BHTR3AHTR3D
SCHEMBL13673467 0.89 PLA2G10 (0.53) IDO1HTR3EHTR3BHTR3AHTR3D
Acetic Acid SCHEMBL3665413 0.87 CES1 (0.52) IDO1HTR3EHTR3BHTR3AHTR3D
SCHEMBL27868161 0.85 HTR3E (0.47) IDO1HTR3EHTR3BHTR3AHTR3D
SCHEMBL5756341 0.84 LMNA (0.57) IDO1HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL26633566 0.82 MAOB (0.62) PRSS1PRSS2PRSS3F2F10
SCHEMBL11344724 0.80 TSHR (0.57) IDO1HTR3EHTR3BHTR3AHTR3D
SCHEMBL2810781 0.80 HTR3E (0.73) HTR3EHTR3BHTR3AHTR3DHTR3C
Phenylacetic Acid SCHEMBL28326941 0.79 AKR1B1 (0.74) IDO1NOS1NOS3NOS2CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120166906-A Two-dimensional/three-dimensional perovskite heterojunction based on amidino cation and application of perovskite heterojunction in solar cell 西安交通大学 2025-06-17 CN claimed
CN-112159411-A Trifluoromethyl substituted pyrimido [1,3] diaza compound and preparation method thereof 南京工业大学 2021-01-01 CN claimed
CN-106083859-B Preparation method of imipenem monohydrate crystal 山东新时代药业有限公司 2021-01-01 CN claimed
CN-120166906-A Two-dimensional/three-dimensional perovskite heterojunction based on amidino cation and application of perovskite heterojunction in solar cell 西安交通大学 2025-06-17 CN disclosed
CN-119390654-A Preparation method of polysubstituted imidazole derivative 广东省科学院化工研究所 2025-02-07 CN disclosed
CN-113644206-A Micron-sized perovskite thick film and preparation method and application thereof 西湖大学 2021-11-12 CN disclosed
CN-112159411-A Trifluoromethyl substituted pyrimido [1,3] diaza compound and preparation method thereof 南京工业大学 2021-01-01 CN disclosed
CN-106083859-B Preparation method of imipenem monohydrate crystal 山东新时代药业有限公司 2021-01-01 CN disclosed
CN-106083859-B Preparation method of imipenem monohydrate crystal 山东新时代药业有限公司 2021-01-01 CN disclosed
US-20190201404-A1 THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2019-07-04 US disclosed
US-10278972-B2 Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them LES LABORATOIRES SERVIER (FR) 2019-05-07 US disclosed
EP-0469685-A1 Tetrahydropyrimidine derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1992-02-05 EP disclosed
US-4871739-A Substituted 6H-7,8-dihydrothiapyrano(3,2-D)-pyrimidines as hyopglycemic agents MERCK & CO., INC. (US) 1989-10-03 US disclosed
US-4522763-A STARTING MATERIALS FOR CROP PROTECTION AGENTS AND SELECTIVE HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1985-06-11 US disclosed
US-4505910-A Amino-pyrimidine derivatives, compositions and use AMERICAN HOME PRODUCTS CORPORATION (US) 1985-03-19 US disclosed
EP-0130735-A1 Amino-pyrimidine derivatives AMERICAN HOME PRODUCTS CORPORATION (US) 1985-01-09 EP disclosed
US-4278673-A Pharmacologically active compounds ALLEN & HANBURYS LIMITED (GB) 1981-07-14 US disclosed
US-RE30511-E ENZYME INHIBITOR, HERBICIDE, CYCLIZATION AMERICAN CYANAMID COMPANY (US) 1981-02-10 US disclosed
US-4168964-A HERBICIDES AMERICAN CYANAMID COMPANY (US) 1979-09-25 US disclosed
US-4107307-A ENZYME INHIBITORS, HERBICIDES, RING CLOSURE AMERICAN CYANAMID COMPANY (US) 1978-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10278972-B2 Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them TYMS, TYMP, TPX2 HTR3E 2843/4885HTR3B 2046/4885HTR3A 3713/4885
US-20190201404-A1 THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM TYMS, TYMP, TPX2 HTR3E 2843/4885HTR3B 2046/4885HTR3A 3713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.