Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Imidazoleacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 4/20 | 0.49 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazoleacetic Acid SCHEMBL360337 | 0.98 | — | — | |
| Imidazoleacetic Acid SCHEMBL15007471 | 0.96 | TBXAS1 (0.56) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL17375738 | 0.96 | TBXAS1 (0.56) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL2827600 | 0.94 | TBXAS1 (0.54) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL26627272 | 0.90 | TBXAS1 (0.51) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL28462628 | 0.90 | TBXAS1 (0.51) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL8706716 | 0.86 | TBXAS1 (0.47) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Imidazoleacetic Acid SCHEMBL16339368 | 0.84 | TBXAS1 (0.46) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| Hydrochloric Acid SCHEMBL3184145 | 0.84 | TBXAS1 (0.51) | TBXAS1GAASMN1; SMN2TAAR1KDM4E | |
| SCHEMBL8519473 | 0.83 | TBXAS1 (0.50) | TBXAS1GAASMN1; SMN2TAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112058103-B | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2022-06-21 | — | — | CN | claimed |
| CN-112058103-A | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2020-12-11 | — | — | CN | claimed |
| WO-2005063717-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ZOLEDRONIC ACID | NATCO PHARMA LIMITED (IN) | 2005-07-14 | — | — | WO | claimed |
| WO-2023145880-A1 | GLUTAMINASE INHIBITOR | 国立大学法人富山大学 | 2023-08-03 | — | — | WO | disclosed |
| CN-112058103-B | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-112058103-B | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-112058103-B | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-112058103-A | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2020-12-11 | — | — | CN | disclosed |
| CN-112058103-A | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2020-12-11 | — | — | CN | disclosed |
| CN-112058103-A | Cellulose grafted carboxymethyl imidazole chloride salt gas separation membrane and preparation method thereof | 齐齐哈尔大学 | 2020-12-11 | — | — | CN | disclosed |
| CN-102775444-A | New preparation method of zoledronic acid | HENGSHUI KANGYI MEDICAL TECHNOLOGY DEV CO LTD | 2012-11-14 | — | — | CN | disclosed |
| WO-2005005447-A2 | ZOLEDRONIC ACID CRYSTAL FORMS, ZOLEDRONATE SODIUM SALT CRYSTAL FORMS, AMORPHOUS ZOLEDRONATE SODIUM SALT, AND PROCESSES FOR THEIR PREPARATION | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-01-20 | — | — | WO | disclosed |
| EP-1020179-A2 | PEPTIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PRODUCING THE SAME, USE OF SAID DERIVATIVES AND PHARMACEUTICAL COMPOSITION | Nebolsin, Vladimir Evgenievich (RU) | 2000-07-19 | — | — | EP | disclosed |
| US-5872135-A | ENZYME INHIBITORS | MERK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| US-5661161-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0783518-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010035-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| EP-0663834-A4 | GROWTH HORMONE RELEASING PEPTIDES. | SMITHKLINE BEECHAM CORP (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0663834-A1 | GROWTH HORMONE RELEASING PEPTIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994007519-A1 | GROWTH HORMONE RELEASING PEPTIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-14 | — | — | WO | disclosed |