Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 known ✓ | Q99500 | 1/20 | 0.42 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.97 |
| ▸ | GBA1 | P04062 | 12/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29521395 | 1.00 | SMPD1 (0.97) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL23064315 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL23064221 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL19197802 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL25329230 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL23064212 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL25329590 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL23064217 | 0.99 | SMPD1 (1.00) | SMPD1GBA1S1PR1S1PR3EPHX2 | |
| SCHEMBL21641693 | 0.93 | SMPD1 (0.89) | SMPD1GBA1S1PR1S1PR3HRH4 | |
| SCHEMBL29520868 | 0.82 | SMPD1 (0.71) | SMPD1GBA1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398109-B2 | 2-amino-2-(1,2,3-triazole-4-yl)propane-1,3-diol derivative of novel compound for directly inhibiting ASM activity, and use thereof | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2025-08-26 | — | — | US | disclosed |
| EP-3789380-B1 | 2-AMINO-2-(1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE OF NOVEL COMPOUND FOR DIRECTLY INHIBITING ASM ACTIVITY, AND USE THEREOF | KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) | 2024-12-04 | — | — | EP | disclosed |
| CN-112351974-B | Novel compound 2-amino-2- (1, 2, 3-triazole-4-yl) -1, 3-propanediol derivative capable of directly inhibiting ASM activity and application thereof | 庆北大学校产学协力团 | 2024-01-26 | — | — | CN | disclosed |
| US-20210188784-A1 | 2-AMINO-2-(1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE OF NOVEL COMPOUND FOR DIRECTLY INHIBITING ASM ACTIVITY, AND USE THEREOF | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KP) | 2021-06-24 | — | — | US | disclosed |
| EP-3789380-A1 | 2-AMINO-2-(1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE OF NOVEL COMPOUND FOR DIRECTLY INHIBITING ASM ACTIVITY, AND USE THEREOF | Kyungpook National University Industry-Academic Cooperation Foundation (KR) | 2021-03-10 | — | — | EP | disclosed |
| CN-112351974-A | Novel compound 2-amino-2- (1,2, 3-triazole-4-yl) -1, 3-propylene glycol derivative for directly inhibiting ASM activity and application thereof | 庆北大学校产学协力团 | 2021-02-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188784-A1 | 2-AMINO-2-(1,2,3-TRIAZOLE-4-YL)PROPANE-1,3-DIOL DERIVATIVE OF NOVEL COMPOUND FOR DIRECTLY INHIBITING ASM ACTIVITY, AND USE THEREOF | CHRNB2, ACHE, SMPD2 | S1PR1 1044/4885S1PR3 1001/4885HRH3 355/4885 |
| US-12398109-B2 | 2-amino-2-(1,2,3-triazole-4-yl)propane-1,3-diol derivative of novel compound for directly inhibiting ASM activity, and use thereof | CHRNB2, ACHE, SMPD2 | S1PR1 1044/4885S1PR3 1001/4885HRH3 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.