Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 14/20 | 0.56 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.42 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.54 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27905027 | 0.98 | CYP19A1 (0.57) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| SCHEMBL28117945 | 0.85 | CYP17A1 (0.49) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| SCHEMBL28178686 | 0.83 | CYP19A1 (0.44) | CYP19A1CYP17A1CYP24A1 | |
| SCHEMBL27581291 | 0.79 | CYP19A1 (0.60) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL28794239 | 0.78 | CYP19A1 (0.59) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL9996088 | 0.78 | CYP19A1 (0.59) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| SCHEMBL27862767 | 0.76 | CYP19A1 (0.60) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| SCHEMBL6949625 | 0.76 | CYP19A1 (0.60) | CYP19A1CYP17A1CYP24A1CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL28775270 | 0.75 | CYP17A1 (0.40) | CYP19A1CYP17A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL27614865 | 0.75 | CYP17A1 (0.40) | CYP19A1CYP17A1CYP3A4MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013162-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION (US) | 2011-09-06 | — | — | US | disclosed |
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION | 2009-08-13 | — | — | US | disclosed |
| US-7550599-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080221332-A1 | Hindered Amine salt compounds | WOOD MARVIN G | 2008-09-11 | — | — | US | disclosed |
| US-7384464-B2 | Ink jet and recording material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1572817-B1 | INK-JET INK AND RECORDING MATERIAL | CIBA SC HOLDING AG (CH) | 2007-03-21 | — | — | EP | disclosed |
| US-20060262149-A1 | Ink jet ink and recording material | WOOD MERVIN G | 2006-11-23 | — | — | US | disclosed |
| WO-2006122888-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | disclosed |
| US-7066990-B2 | Ink jet ink and recording material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| EP-1362083-B1 | INK-JET INK AND RECORDING MATERIAL | CIBA SC HOLDING AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | disclosed |
| US-5509957-A | STABILIZERS FOR INK JET PRINTING | CIBA-GEIGY CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |
| US-5489503-A | BIS- OR TRIS-2'HYDROXYPHENYLTRIAZINES; PHOTOGRAPHIC MATERIALS, INKS AND RECORDING MATERIALS FOR INK-JET PRINTING AND SURFACE COATINGS | CIBA-GEIGY CORP. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5261953-A | CONTAINING WATER SOLUBLE STABILIZER TO IMPROVE COLORFASTNESS | CIBA-GEIGY CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| US-5124723-A | 2-(2'-hydroxyphenyl) benzotriazoles | CIBA-GEIGY CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |
| US-5096781-A | Amine salts or quaternized compounds of 2,4-diphenyl-6-/2-/hydroxyphenyl/-s-triazine derivatives; color- and washfast inks for jet printing and recording | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-5096489-A | 2-hydroxyphenyl-s-triazines | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-5089050-A | Phenol derivatives | CIBA-GEIGY CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |
| US-5073448-A | Containing light stabilizers | CIBA-GEIGY CORPORATION (US) | 1991-12-17 | — | — | US | disclosed |
| US-4926190-A | EMULSIONS | CIBA-GEIGY CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | AAAS, IWS1, HTR7 | CYP19A1 2554/4885HSP90AA1 135/4885MAOA 214/4885 |
| US-20080221332-A1 | Hindered Amine salt compounds | SLC7A1, H1-0, SLC3A2 | CYP19A1 2216/4885HSP90AA1 2745/4885MAOA 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.