Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA known ✓ | P06280 | 2/20 | 0.47 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.47 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.44 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31432735 | 1.00 | RIPK1 (0.47) | RIPK1MEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1360303 | 1.00 | RIPK1 (0.47) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL381516 | 0.98 | MEN1 (0.49) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29672339 | 0.96 | RIPK1 (0.47) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29513438 | 0.96 | NPC1 (0.48) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23084560 | 0.89 | RIPK1 (0.47) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2245048 | 0.87 | NPC1 (0.63) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL19200893 | 0.84 | MMP2 (0.54) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29513472 | 0.83 | NPC1 (0.55) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL1663580 | 0.82 | CYP2A6 (0.55) | RIPK1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105063064-B | Improved vaccines and methods of use thereof | 宾夕法尼亚大学托管会 | 2024-09-24 | — | — | CN | disclosed |
| EP-4400510-A2 | IMPROVED VACCINES AND METHODS FOR USING THE SAME | The Trustees of the University of Pennsylvania (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-3907232-B1 | IMPROVED HIV VACCINES | UNIV PENNSYLVANIA (US) | 2024-02-21 | — | — | EP | disclosed |
| CN-112961858-B | Construction and application of T-ALL drug resistance model | 深圳市罗湖区人民医院 | 2023-03-28 | — | — | CN | disclosed |
| EP-3907232-A1 | IMPROVED HIV VACCINES | The Trustees of the University of Pennsylvania (US) | 2021-11-10 | — | — | EP | disclosed |
| EP-3489251-B1 | HIV CONSENSUS PROTEINS AND VACCINES MADE THEREFROM | UNIV PENNSYLVANIA (US) | 2021-03-17 | — | — | EP | disclosed |
| EP-3489251-A1 | IMPROVED VACCINES AND METHODS FOR USING THE SAME | The Trustees of the University of Pennsylvania (US) | 2019-05-29 | — | — | EP | disclosed |
| EP-3037429-B1 | IMPROVED HIV VACCINES | UNIV PENNSYLVANIA (US) | 2018-09-26 | — | — | EP | disclosed |
| EP-2708549-B1 | Improved vaccines for targetting telomerase | UNIV PENNSYLVANIA (US) | 2016-07-06 | — | — | EP | disclosed |
| EP-3037429-A1 | IMPROVED VACCINES AND METHODS FOR USING THE SAME | The Trustees Of The University Of Pennsylvania (US) | 2016-06-29 | — | — | EP | disclosed |
| US-9376471-B2 | HIV consensus envelope sequences and methods for using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-06-28 | — | — | US | disclosed |
| EP-2594576-B1 | Improved HIV vaccines | UNIV PENNSYLVANIA (US) | 2015-07-01 | — | — | EP | disclosed |
| US-20140341941-A1 | VACCINES AND METHODS FOR USING THE SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-11-20 | — | — | US | disclosed |
| US-8697084-B2 | HIV consensus envelope sequences and methods for using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-04-15 | — | — | US | disclosed |
| EP-2708549-A2 | Improved vaccines and methods for using the same | The Trustees of The University of Pennsylvania (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2594576-A1 | Improved vaccines and methods for using the same | The Trustees of The University of Pennsylvania (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20130004529-A1 | VACCINES AND METHODS FOR USING THE SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2013-01-03 | — | — | US | disclosed |
| EP-2049559-B1 | IMPROVED HPV VACCINES | UNIV PENNSYLVANIA (US) | 2012-12-19 | — | — | EP | disclosed |
| US-8168769-B2 | HPV vaccines and methods for using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100166787-A1 | VACCINES AND METHODS FOR USING THE SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2010-07-01 | — | — | US | disclosed |