Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.46 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.40 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.52 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | F11 | P03951 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28110057 | 1.00 | HRH3 (0.55) | HRH3LOXL2ABATF11CA1 | |
| SCHEMBL16472531 | 0.97 | — | — | |
| Bromide SCHEMBL27738733 | 0.94 | HRH3 (0.55) | HRH3LOXL2ABATF11CA1 | |
| SCHEMBL27597947 | 0.94 | HRH3 (0.55) | HRH3LOXL2ABATF11CA1 | |
| Water SCHEMBL28264730 | 0.94 | HRH3 (0.55) | HRH3LOXL2ABATF11CA1 | |
| Naphthalene SCHEMBL28166813 | 0.85 | LOXL2 (0.52) | HRH3LOXL2ABATCA1CA2 | |
| Hydrochloric Acid SCHEMBL3168189 | 0.84 | HRH3 (0.73) | HRH3LOXL2ABATF11CA1 | |
| Hydrochloric Acid SCHEMBL3162690 | 0.84 | HRH3 (0.73) | HRH3LOXL2ABATF11CA1 | |
| SCHEMBL27238704 | 0.80 | HRH3 (0.79) | HRH3LOXL2ABATF11CA1 | |
| SCHEMBL15828 | 0.80 | HRH3 (0.79) | HRH3LOXL2ABATF11CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107936057-B | A kind of preparation method of diaryl phosphorus chlorine compound | 河南省科学院化学研究所有限公司 | 2019-07-16 | — | — | CN | claimed |
| CN-107936057-B | A kind of preparation method of diaryl phosphorus chlorine compound | 河南省科学院化学研究所有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-107936057-A | A kind of preparation method of diaryl phosphorus chlorine compound | 河南省科学院化学研究所有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107569518-A | The dissolving method of the egg shell membrane of enzyme is used | 天野酶制品株式会社 | 2018-01-12 | — | — | CN | disclosed |
| CN-106853379-A | A kind of ternary catalyst systems and its application in ethylene selectivity oligomerisation | 中国科学院大连化学物理研究所 | 2017-06-16 | — | — | CN | disclosed |
| CN-106831381-A | The preparation method of 3-HPA | 中国石油化工股份有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-106083927-A | Phosphinyl amidine compound, metal complex, antigravity system and their oligomeric or purposes of olefin polymerization | 切弗朗菲利浦化学公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105829329-A | Phosphinyl formamidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | 切弗朗菲利浦化学公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-102781949-B | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use for oligomerizing or polymerizing olefins | 切弗朗菲利浦化学公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-104059105-B | Ligand compound containing pyridine radicals, the catalyst containing this compound and application thereof | 中国石油化工股份有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105671018-A | Eggshell membrane solubilization method using enzymes | 天野酶制品株式会社 | 2016-06-15 | — | — | CN | disclosed |
| CN-104059105-A | Ligand compound containing pyridyl group, and catalyst containing ligand compound and application thereof | CHINA PETROLEUM & CHEMICAL | 2014-09-24 | — | — | CN | disclosed |
| CN-103069000-A | Method for dissolving eggshell membrane using enzyme | AMANO ENZYME INC | 2013-04-24 | — | — | CN | disclosed |
| CN-102781949-A | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use for oligomerizing or polymerizing olefins | CHEVRON PHILLIPS CHEMICAL CO | 2012-11-14 | — | — | CN | disclosed |
| CN-1224427-A | 6-O-substituted erythromycin compounds and preparation method thereof | ABBOTT LAB (US) | 1999-07-28 | — | — | CN | disclosed |