Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 10/20 | 0.84 |
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.68 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.68 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.68 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.68 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.68 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.68 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.68 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.68 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.68 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.68 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.68 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.64 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 0.64 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.64 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2791187 | 1.00 | KCNH2 (0.84) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| SCHEMBL12128150 | 0.98 | KCNH2 (0.87) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| SCHEMBL640157 | 0.98 | KCNH2 (0.87) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| SCHEMBL12128156 | 0.98 | KCNH2 (0.87) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| SCHEMBL12128145 | 0.96 | KCNH2 (0.83) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL23235958 | 0.93 | OPRM1 (0.72) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL10579648 | 0.93 | OPRM1 (0.72) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL5603796 | 0.93 | OPRM1 (0.72) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL5370094 | 0.93 | OPRM1 (0.72) | KCNH2OPRM1DRD3CHRM2HTR1A | |
| SCHEMBL11131429 | 0.91 | KCNH2 (0.93) | KCNH2OPRM1DRD3CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12569426-B2 | Topical skin preparation composition | KAO CORPORATION (JP) | 2026-03-10 | — | — | US | disclosed |
| US-20250009630-A1 | WATER-IN-OIL EMULSION COSMETIC | SHISEIDO COMPANY, LTD. (JP) | 2025-01-09 | — | — | US | disclosed |
| US-20240398683-A1 | WATER-IN-OIL EMULSION COSMETIC | SHISEIDO COMPANY, LTD. (JP) | 2024-12-05 | — | — | US | disclosed |
| US-12090218-B2 | Water-in-oil emulsion composition | SHISEIDO COMPANY, LTD. (JP) | 2024-09-17 | — | — | US | disclosed |
| US-20240225975-A9 | AN IMPROVED LONG WEARING SUNSCREEN COSMETIC | BASF SE (DE) | 2024-07-11 | — | — | US | disclosed |
| US-20240130940-A1 | AN IMPROVED LONG WEARING SUNSCREEN COSMETIC | BASF SE (DE) | 2024-04-25 | — | — | US | disclosed |
| EP-4349415-A1 | WATER-IN-OIL EMULSION COMPOSITION | Kao Corporation (JP) | 2024-04-10 | — | — | EP | disclosed |
| US-11931435-B2 | Water-in-oil type emulsified cosmetic | SHISEIDO COMPANY, LTD. (JP) | 2024-03-19 | — | — | US | disclosed |
| EP-4294534-A1 | AN IMPROVED LONG WEARING SUNSCREEN COSMETIC | BASF SE (DE) | 2023-12-27 | — | — | EP | disclosed |
| US-11801207-B2 | Water-in-oil emulsion sunscreen cosmetic | SHISEIDO COMPANY, LTD. (JP) | 2023-10-31 | — | — | US | disclosed |
| US-20010044475-A1 | Gelling agent and gel compositions | SHISEIDO COMPANY, LTD. (JP) | 2001-11-22 | — | — | US | disclosed |
| EP-0765656-B1 | Water-in-oil type emulsion cosmetic composition | SHISEIDO CO LTD (JP) | 2001-07-04 | — | — | EP | disclosed |
| US-5985177-A | STABILIZATION OF OIL-SOLUBLE AGENTS BLENDED IN THE INNER OIL PHASE, ORGANOPHILIC CLAY MINERAL IS AN INCLUSION COMPOUND WHICH IS FORMED BY CATION EXCHANGE REACTION BETWEEN A WATER SWELLABLE-CLAY MINERAL AND A QUATERNARY AMMONIUM CATION AND | SHISEIDO CO., LTD. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0922740-A1 | GELLING AGENT AND GEL COMPOSITIONS | SHISEIDO COMPANY LIMITED (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5853711-A | Water-in-oil emulsion cosmetic composition | SHISEIDO COMPANY, LTD (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0782846-A2 | O/W/O type multiple emulsion and method of preparing the same | SHISEIDO COMPANY LIMITED (JP) | 1997-07-09 | — | — | EP | disclosed |
| EP-0765656-A1 | Water-in-oil type emulsion cosmetic composition | SHISEIDO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |
| EP-0331833-B1 | WATER-IN-OIL EMULSION TYPE COSMETICS | SHISEIDO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5015469-A | Water swellable clays, cationic surfactants, an alkoxy modified polysiloxane in water | SHIDEIDO COMPANY LTD. (JP) | 1991-05-14 | — | — | US | disclosed |
| EP-0331833-A1 | Water-in-oil emulsion type cosmetics | SHISEIDO COMPANY LIMITED (JP) | 1989-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11801207-B2 | Water-in-oil emulsion sunscreen cosmetic | TYR, CUTA, LBR | KCNH2 256/4885OPRM1 4250/4885DRD3 2861/4885 |
| US-20240398683-A1 | WATER-IN-OIL EMULSION COSMETIC | PRKAR2A, MC1R, CUTA | KCNH2 1737/4885OPRM1 3356/4885DRD3 2603/4885 |
| US-11931435-B2 | Water-in-oil type emulsified cosmetic | LRBA, CUTA, LBR | KCNH2 796/4885OPRM1 4198/4885DRD3 2413/4885 |
| US-12090218-B2 | Water-in-oil emulsion composition | PHOSPHO1, ACTB, POLB | KCNH2 4425/4885OPRM1 364/4885DRD3 2117/4885 |
| US-12569426-B2 | Topical skin preparation composition | KRT18, CUTA, TMSB10 | KCNH2 558/4885OPRM1 3396/4885DRD3 2360/4885 |
| US-20250009630-A1 | WATER-IN-OIL EMULSION COSMETIC | CUTA, LIPA, H1-0 | KCNH2 566/4885OPRM1 4182/4885DRD3 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.