Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Indole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.94 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.44 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.44 |
| ▸ | IMPDH2 known ✓ | P12268 | 1/20 | 0.40 |
| ▸ | IMPDH1 known ✓ | P20839 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 7/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA4 | P22748 | 2/20 | 0.94 |
| ▸ | CA6 | P23280 | 2/20 | 0.94 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.94 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.94 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.94 |
| ▸ | ITGAL | P20701 | 1/20 | 0.94 |
| ▸ | ADK | P55263 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL29646222 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL10464295 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30172823 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL1354880 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL7562348 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29418280 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL1475229 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL23704202 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29800701 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9215713 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2290877-A | — | — | None | — | — | JP | disclosed |
| US-8247407-B2 | Pharmaceutical composition with anti-diabetic action | Zakrytoe Artsionernoe Obschestvo “Masterclone” (RU) | 2012-08-21 | — | — | US | disclosed |
| US-20100168092-A1 | PHARMACEUTICAL COMPOSITION WITH ANTI-DIABETIC ACTION | ZAKRYTOE ARTSINONEMOE OBSCHESTO "MASTERCLONE" | 2010-07-01 | — | — | US | disclosed |
| EP-0392913-B1 | (3-Diethylaminopropyl)-1-amino-5-methyldipyrido [4,3-b] [3,4-f] indole trihydrochloride | ELF SANOFI (FR) | 1993-06-23 | — | — | EP | disclosed |
| JP-H02290877-A | 1-(3-DIETHYLAMINOPROPYL)AMINO-5-METHYLDIPYRIDO (4,3-B) (3,4-F1 INDOLE TRIHYDROCHLORIDE | SANOFI SA | 1990-11-30 | — | — | JP | disclosed |
| EP-0392913-A1 | (3-Diethylaminopropyl)-1-amino-5-methyldipyrido [4,3-b] [3,4-f] indole trihydrochloride | ELF SANOFI (FR) | 1990-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168092-A1 | PHARMACEUTICAL COMPOSITION WITH ANTI-DIABETIC ACTION | IAPP, GPR119, PNLIP | CA2 2196/4885PARP1 3102/4885GAA 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.