Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL6416931 | 1.00 | THRB (0.50) | THRBTSHRALDH1A1MAPTGLO1 | |
| Methacrylic Acid SCHEMBL5987967 | 1.00 | THRB (0.50) | THRBTSHRALDH1A1MAPTGLO1 | |
| Methacrylic Acid SCHEMBL22164150 | 0.98 | THRB (0.52) | THRBTSHRALDH1A1MAPTGLO1 | |
| Trimethylammonium SCHEMBL332711 | 0.94 | THRB (0.55) | THRBTSHRALDH1A1MAPTGLO1 | |
| Trimethylammonium SCHEMBL6416933 | 0.94 | THRB (0.55) | THRBTSHRALDH1A1MAPTGLO1 | |
| Trimethylammonium SCHEMBL27520704 | 0.92 | THRB (0.53) | THRBTSHRALDH1A1MAPTGLO1 | |
| Methacrylic Acid SCHEMBL2802555 | 0.92 | THRB (0.57) | THRBTSHRALDH1A1MAPTGLO1 | |
| Methacrylic Acid SCHEMBL974640 | 0.92 | THRB (0.57) | THRBTSHRALDH1A1MAPTGLO1 | |
| Methacrylic Acid SCHEMBL9472725 | 0.92 | THRB (0.57) | THRBTSHRALDH1A1MAPTGLO1 | |
| Trimethylammonium SCHEMBL421649 | 0.92 | THRB (0.57) | THRBTSHRALDH1A1MAPTGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107205937-A | Pharmaceutical bead formulations comprising dimethyl fumarate | 比奥根MA公司 | 2017-09-26 | — | — | CN | claimed |
| CN-107107463-B | Production of solid dosage forms | 中央兰开夏大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-110381925-A | The pharmaceutical preparation of phloroglucin and TRIMETHYL PHLOROGLUCINOL | 辛瑞克斯制药有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110105487-A | Polymerisation in solution preparation method containing quaternary ammonium group (methyl) acrylate copolymer | 广州茂丰药业有限公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-109996563-A | The preparation and its preparation and application that the preparation, taste of 4- methyl -5- (pyrazine -2- base) -3H-1,2- dithiole -3- thioketones are improved | ST知识产权控股公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109996562-A | The preparation and its preparation and application of 4- methyl -5- (pyrazine -2- base) -3H-1,2- dithiole -3- thioketones | ST知识产权控股公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109789639-A | Production of solid dosage forms | 中央兰开夏大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-108883120-A | Vitamin D treatment method | 欧普科爱尔兰环球控股有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-108135833-A | The pharmaceutical composition of the fiber obtained by Hydroelectric power is included, the composition has the residence time improved on application site | 德姆特里特有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-108135968-A | Chimeric polyeptides assembly and its preparation and application | 阿穆尼克斯运营公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107278150-A | Method for providing the film comprising pigment on keratin fiber | 诺赛尔股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107205937-A | Pharmaceutical bead formulations comprising dimethyl fumarate | 比奥根MA公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107107463-A | Production of solid dosage forms | 中央兰开夏大学 | 2017-08-29 | — | — | CN | disclosed |
| CN-103154041-B9 | Method for producing (meth) acrylate copolymers containing tertiary amino groups by radical polymerization in solution | 赢创罗姆有限公司 | 2016-07-06 | — | — | CN | disclosed |