Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Vanillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 known ✓ | P28845 | 2/20 | 0.60 |
| ▸ | TTR known ✓ | P02766 | 1/20 | 0.59 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.58 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.57 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.57 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.57 |
| ▸ | TOP2A known ✓ | P11388 | 1/20 | 0.57 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.57 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.57 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.57 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.57 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.57 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.57 |
| ▸ | PRKCE known ✓ | Q02156 | 1/20 | 0.57 |
| ▸ | PRKCQ known ✓ | Q04759 | 1/20 | 0.57 |
| ▸ | PRKCD known ✓ | Q05655 | 1/20 | 0.57 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 known ✓ | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 known ✓ | Q969S8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vanillin SCHEMBL4442606 | 0.98 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL29114070 | 0.98 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL1213 | 0.96 | ALDH1A1 (1.00) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL720723 | 0.96 | ALDH1A1 (1.00) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL29354839 | 0.96 | ALDH1A1 (1.00) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL28387598 | 0.95 | ALDH1A1 (0.89) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL19411839 | 0.94 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL8853913 | 0.94 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL19149274 | 0.94 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 | |
| Vanillin SCHEMBL20549709 | 0.94 | ALDH1A1 (0.96) | ALDH1A1HPGDTDP1TRIM24ALDH5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117945940-A | Synthesis method of N-vanillyl monoamide succinic acid | 石河子大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117946249-A | Synthetic method and application of capsaicin artificial antigen | 石河子大学 | 2024-04-30 | — | — | CN | claimed |
| CN-115015426-B | Method for detecting concentration of catecholamine metabolite in urine | 北京豪思生物科技股份有限公司 | 2024-01-19 | — | — | CN | claimed |
| CN-117105799-A | Synthesis method of dihydrocapsaicin | 苏州华道生物药业股份有限公司 | 2023-11-24 | — | — | CN | claimed |
| CN-114994211-B | Kit for detecting catecholamine metabolite content in human urine and application thereof | 北京豪思生物科技股份有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-116715821-A | Bio-based recyclable polyurethane foam and preparation method thereof | 贵州大学 | 2023-09-08 | — | — | CN | claimed |
| CN-116162975-A | Nickel oxide modified stainless steel and preparation method and application thereof | 湖北振华化学股份有限公司 | 2023-05-26 | — | — | CN | claimed |
| CN-115819255-A | Synthesis method of capsaicin substance | 湖北航天化学技术研究所 | 2023-03-21 | — | — | CN | claimed |
| CN-115015426-A | Method for detecting concentration of catecholamine metabolites in urine | 北京豪思生物科技股份有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-114994211-A | Kit for detecting catecholamine metabolite content in human urine and application thereof | 北京豪思生物科技股份有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-110045108-B | Capsaicin index-based illegal cooking oil enzyme-linked immunosorbent assay kit and detection method thereof | 江南大学 | 2021-10-29 | — | — | CN | claimed |
| CN-113463144-A | Method for plating nickel on surface of brass substrate | 惠州市安泰普表面处理科技有限公司 | 2021-10-01 | — | — | CN | claimed |
| CN-111208296-A | Barreled colloidal gold microporous test strip for detecting capsaicin in edible oil, and preparation method and detection method thereof | 武汉华美维士康生物工程有限公司 | 2020-05-29 | — | — | CN | claimed |
| CN-110698336-A | Preparation method of high-purity vanillin amine hydrochloride | 安徽世华化工有限公司 | 2020-01-17 | — | — | CN | claimed |
| CN-117105799-B | Dihydro chilli Process for synthesizing alkali | 苏州华道生物药业股份有限公司 | 2025-06-06 | — | — | CN | disclosed |
| CN-115335358-B | Synthesis of Capsaicin Derivatives | 阿克西赫姆公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-117945940-A | Synthesis method of N-vanillyl monoamide succinic acid | 石河子大学 | 2024-04-30 | — | — | CN | disclosed |
| US-20100129515-A1 | FLAVOUR MODULATING SUBSTANCES | QUEST INTERNATIONAL SERVICES B.V. (NL) | 2010-05-27 | — | — | US | disclosed |
| EP-1915063-A2 | N-VANILLYL UREA DERIVATIVES AS FLAVOUR MODULATING SUBSTANCES | Quest International Services B.V. (NL) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007013811-A2 | N-VANILLYL UREA DERIVATIVES AS FLAVOUR MODULATING SUBSTANCES | QUEST INTERNATIONAL SERVICES B.V. (NL) | 2007-02-01 | — | — | WO | disclosed |