Fenoxazoline

Fenoxazoline

SCHEMBL317133

CC(C)c1ccccc1OCC1=NCCN1.Cl

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Fenoxazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR1A known ✓ P08908 4/20 0.62
ADRA2A known ✓ P08913 4/20 0.62
ADRA2B known ✓ P18089 4/20 0.62
ADRA2C known ✓ P18825 4/20 0.62
ADRA1A known ✓ P35348 6/20 0.59
ADRA1B known ✓ P35368 5/20 0.59
ADRA1D known ✓ P25100 4/20 0.59
MAOA known ✓ P21397 3/20 0.59
MAOB known ✓ P27338 3/20 0.59
NISCH Q9Y2I1 12/20 0.97
LMNA P02545 1/20 0.60
CYP1A2 P05177 1/20 0.58
CYP2D6 P10635 1/20 0.58
THRB P10828 1/20 0.58
TSHR P16473 1/20 0.58
CYP2C19 P33261 1/20 0.58
THPO P40225 1/20 0.58
HSD17B10 Q99714 1/20 0.58
TAAR1 Q96RJ0 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenoxazoline SCHEMBL193061 0.99 NISCH (1.00) NISCHHTR1AADRA2AADRA2BADRA2C
Fenoxazoline SCHEMBL1650113 0.97 NISCH (0.97) NISCHHTR1AADRA2AADRA2BADRA2C
Tymazoline SCHEMBL28142132 0.89 NISCH (0.81) NISCHHTR1AADRA2AADRA2BADRA2C
Fenoxazoline SCHEMBL28086604 0.85 NISCH (0.74) NISCHHTR1AADRA2AADRA2BADRA2C
Tymazoline SCHEMBL4415590 0.83 NISCH (0.68) NISCHHTR1AADRA2AADRA2BADRA2C
Tymazoline SCHEMBL250491 0.81 NISCH (0.70) NISCHHTR1AADRA2AADRA2BADRA2C
Tymazoline SCHEMBL29387735 0.81 NISCH (0.70) NISCHHTR1AADRA2AADRA2BADRA2C
SCHEMBL3168567 0.80 NISCH (0.73) NISCHHTR1AADRA2AADRA2BADRA2C
SCHEMBL3169242 0.77 NISCH (0.68) NISCHHTR1AADRA2AADRA2BADRA2C
Hydrochloric Acid SCHEMBL9654109 0.76 NISCH (0.76) NISCHHTR1AADRA2AADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9757376-B2 Pharmaceutical compositions GM PHARMACEUTICALS, INC. (US) 2017-09-12 US claimed
EP-1940352-A1 METHOD OF PREPARING AN AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING HYDROXYPROPYL METHYLCELLULOSE AND PHARMACEUTICAL C0MP0SITI0NS OBTAINABLE Fortune Apex Development Limited (VG) 2008-07-09 EP claimed
US-20070104791-A1 Method of preparing a pharmaceutical composition and pharmaceutical compositions obtainable thereby FORTUNE APEX DEVELOPMENT LIMITED (VG) 2007-05-10 US claimed
WO-2007049102-A1 METHOD OF PREPARING AN AQUEOUS PHARMACEUTICAL COMPOSITION COMPRISING HYDROXYPROPYL METHYLCELLULOSE AND PHARMACEUTICAL C0MP0SITI0NS OBTAINABLE FORTUNE APEX DEVELOPMENT LIMITED (VG) 2007-05-03 WO claimed
EP-1641446-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF Pediamed Pharmaceuticals, Inc. (US) 2006-04-05 EP claimed
WO-2004112771-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF PEDIAMED PHARMACEUTICALS, INC. (US) 2004-12-29 WO claimed
US-20040259809-A1 Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof PEDIAMED PHARMACEUTICALS, INC. 2004-12-23 US claimed
US-12377075-B2 Device for internal and external nasal application HALEON CH SARL (CH) 2025-08-05 US disclosed
EP-4058112-B1 DEVICE FOR INTERNAL AND EXTERNAL NASAL APPLICATION GSK CONSUMER HEALTHCARE SARL (CH) 2023-12-27 EP disclosed
US-20220387389-A1 DEVICE FOR INTERNAL AND EXTERNAL NASAL APPLICATION HALEON CH SARL (CH) 2022-12-08 US disclosed
EP-4058112-A1 DEVICE FOR INTERNAL AND EXTERNAL NASAL APPLICATION GSK Consumer Healthcare SARL (CH) 2022-09-21 EP disclosed
EP-3821927-B1 DEVICE FOR INTERNAL AND EXTERNAL NASAL APPLICATION GSK CONSUMER HEALTHCARE SARL (CH) 2022-01-19 EP disclosed
WO-2021094451-A1 DEVICE FOR INTERNAL AND EXTERNAL NASAL APPLICATION GSK Consumer Healthcare S.A. (CH) 2021-05-20 WO disclosed
EP-1438942-A1 An otorhinological drug delivery device Schering Oy (FI) 2004-07-21 EP disclosed
WO-2004000272-A1 NASAL COMPOSITIONS COMPRISING A MUCOPOLYSACCHARIDE AND PROPYLENE GLYCOL NOVARTIS CONSUMER HEALTH S.A. (CH) 2003-12-31 WO disclosed
US-20020193417-A1 Nasal solutions SEIDEL MATTHIAS (CH) 2002-12-19 US disclosed
EP-1051155-B1 NASAL SOLUTIONS NOVARTIS CONSUMER HEALTH SA (CH) 2002-06-26 EP disclosed
US-20010053775-A1 Nasal solutions SEIDEL MATTHIAS (CH) 2001-12-20 US disclosed
EP-1051155-A1 NASAL SOLUTIONS Novartis Consumer Health S.A. (CH) 2000-11-15 EP disclosed
WO-1999038492-A1 NASAL SOLUTIONS NOVARTIS CONSUMER HEALTH S.A. (CH) 1999-08-05 WO disclosed