Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.52 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1564027 | 1.00 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL711798 | 0.97 | ALDH1A1 (0.63) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL23288 | 0.97 | ALDH1A1 (0.63) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL10454889 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| Water SCHEMBL2004054 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL723062 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| Lithium SCHEMBL31339528 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| Water SCHEMBL713566 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL1535448 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 | |
| SCHEMBL31253427 | 0.94 | ALDH1A1 (0.60) | ALDH1A1ALOX15CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105229080-A | Halogen-free flame-retardant polycarbonate | BAYER MATERIALSCIENCE LLC | 2016-01-06 | — | — | CN | disclosed |
| EP-1709100-B1 | COMPOSITIONS USEFUL AS COATINGS, THEIR PREPARATION, AND ARTICLES MADE THEREFROM | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-07-10 | — | — | EP | disclosed |
| CN-101160340-B | Transparent compositions, methods for the preparation thereof, and articles derived therefrom | GEN ELECTRIC | 2012-06-27 | — | — | CN | disclosed |
| CN-1902274-B | Water resistant permanent antistatic thermoplastic composition | SABIC INNOVATIVE PLASTICS IP | 2011-08-17 | — | — | CN | disclosed |
| EP-2195381-A2 | BLOCK COPOLYMERS HAVING DISTINCT ISOPRENE AND BUTADIENE MIDBLOCKS, METHOD FOR MAKING SAME, AND USES FOR SUCH BLOCK COPOLYMERS | Kraton Polymers U.S. LLC (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009032501-A2 | BLOCK COPOLYMERS HAVING DISTINCT ISOPRENE AND BUTADIENE MIDBLOCKS, METHOD FOR MAKING SAME, AND USES FOR SUCH BLOCK COPOLYMERS | KRATON POLYMERS US LLC (US) | 2009-03-12 | — | — | WO | disclosed |
| EP-1971646-A1 | POLYARYLATE COMPOSITIONS USEFUL AS COATINGS , THEIR PREPARATION, AND ARTICLES MADE THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2008-09-24 | — | — | EP | disclosed |
| CN-100342437-C | Limited-play optical media with improved shelf-life and playability | GEN ELECTRIC (US) | 2007-10-10 | — | — | CN | disclosed |
| WO-2007067247-A1 | POLYARYLATE COMPOSITIONS USEFUL AS COATINGS , THEIR PREPARATION, AND ARTICLES MADE THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | WO | disclosed |
| CN-1902274-A | Water resistant permanent antistatic thermoplastic composition | GEN ELECTRIC (US) | 2007-01-24 | — | — | CN | disclosed |
| US-20060093826-A1 | Compositions useful as coatings, their preparation, and articles made therefrom | GENERAL ELECTRIC COMPANY (US) | 2006-05-04 | — | — | US | disclosed |
| WO-2005109101-A1 | PHOTOCURABLE COMPOSITIONS AND FLEXOGRAPHIC PRINTING PLATES COMPRISING THE SAME | KRATON POLYMERS RESEACH B.V. (NL) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005073271-A1 | COMPOSITIONS USEFUL AS COATINGS, THEIR PREPARATION, AND ARTICLES MADE THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050159542-A1 | Compositions useful as coatings, their preparation, and articles made therefrom | GENERAL ELECTRIC COMPANY | 2005-07-21 | — | — | US | disclosed |
| CN-1171949-C | Improved flow carbonate polymer blends | 陶氏环球技术公司 | 2004-10-20 | — | — | CN | disclosed |
| CN-1434842-A | Improved flow carbonate polymer blends | DOW CHEMICAL CO (US) | 2003-08-06 | — | — | CN | disclosed |
| US-5049644-A | Self-extinguishing | ENICHEM TECNORESINE S.P.A. (IT) | 1991-09-17 | — | — | US | disclosed |
| EP-0417897-A1 | Amide-imide copolymer resin of lowered water absorption and composites made therefrom | AMOCO CORPORATION (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0373690-A2 | Flame-resistant polycarbonates containing units deriving from halogenated triphenolbenzamido compounds in their polymer chain | ENICHEM S.p.A. (IT) | 1990-06-20 | — | — | EP | disclosed |
| US-4409201-A | Pressure-resistant microcapsules with a polyamide shell and a polyurethane-polyurea inner mass and process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-10-11 | — | — | US | disclosed |