Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Orthotolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.94 |
| ▸ | TSHR | P16473 | 5/20 | 0.94 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | S100B | P04271 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orthotolidine SCHEMBL867121 | 1.00 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL38664709 | 1.00 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL864763 | 0.97 | CYP3A4 (0.90) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL29386552 | 0.97 | CYP3A4 (1.00) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL49414 | 0.97 | CYP3A4 (1.00) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL29365329 | 0.97 | CYP3A4 (1.00) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL11189493 | 0.94 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| SCHEMBL8954009 | 0.94 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL20547383 | 0.94 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 | |
| Orthotolidine SCHEMBL22129692 | 0.94 | CYP3A4 (0.94) | CYP3A4TDP1ALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103170083-A | Fire extinguishing composition containing transition metal compound | SHAANXI J & R FIRE FIGHTING CO | 2013-06-26 | — | — | CN | claimed |
| EP-0918881-B1 | DRY REAGENT TEST STRIP COMPRISING BENZIDINE DYE PRECURSOR AND ANTIPYRINE COMPOUND | AMIRA MEDICAL (US) | 2004-02-11 | — | — | EP | claimed |
| US-5824491-A | OXIDASE ENZYME AS ANALYTE ON SUBSTRATE, FORMING PEROXIDE, BENZIDINE DYE PRECURSOR, PEROXIDASE ENZYME WITH ANTIPYRENE COMPOUND | MERCURY DIAGNOSTICS, INC. (US) | 1998-10-20 | — | — | US | claimed |
| US-4129417-A | Multisystem test means | MILES LABORATORIES, INC. (US) | 1978-12-12 | — | — | US | claimed |
| CN-106662573-B | For determining the container of urinary precipitation in analyte and/or chemico-physical parameter and determining urine in urine；And the method for using the container carrying out full urinalysis | 赛克利普有限公司 | 2019-10-11 | — | — | CN | disclosed |
| EP-3155421-B1 | CONTAINER FOR DETERMINING OF ANALYTES AND/OR CHEMICO-PHYSICAL PARAMETERS, AS WELL AS DETERMINING OF URINARY SEDIMENT, IN URINE; AND METHOD OF FULL URINE ANALYSIS USING THIS CONTAINER | SIKELIUP S R L (IT) | 2019-02-20 | — | — | EP | disclosed |
| US-20180202992-A1 | CONTAINER FOR DETERMINING OF ANALYTES AND/OR CHEMICO-PHYSICAL PARAMETERS, AS WELL AS DETERMINING OF URINARY SEDIMENT, IN URINE; AND METHOD OF FULL URINE ANALYSIS USING THIS CONTAINER | SIKELIUP S.R.L. (IT) | 2018-07-19 | — | — | US | disclosed |
| US-9949671-B2 | Diagnostic mouthpieces | ORTHOACCEL TECHNOLOGIES, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170181675-A9 | DIAGNOSTIC MOUTHPIECES | ORTHOACCEL HOLDINGS, LLC | 2017-06-29 | — | — | US | disclosed |
| CN-106662573-A | Container for determining of analytes and/or chemico-physical parameters, as well as determining of urinary sediment, in urine; and method of full urine analysis using this container | 赛克利普有限公司 | 2017-05-10 | — | — | CN | disclosed |
| EP-3155421-A1 | CONTAINER FOR DETERMINING OF ANALYTES AND/OR CHEMICO-PHYSICAL PARAMETERS, AS WELL AS DETERMINING OF URINARY SEDIMENT, IN URINE; AND METHOD OF FULL URINE ANALYSIS USING THIS CONTAINER | Sikeliup S.r.l. (IT) | 2017-04-19 | — | — | EP | disclosed |
| CN-103170083-B | Fire extinguishing composition containing transition metal compound | XI'AN J & R FIRE FIGHTING EQUIPMENT Co.,Ltd. (CN) | 2016-04-06 | — | — | CN | disclosed |
| EP-0444263-A1 | Improved composition, device and method of assaying for peroxidatively active substances | Bayer Corporation (US) | 1991-09-04 | — | — | EP | disclosed |
| EP-0299044-A4 | DRY REAGENT DELIVERY SYSTEM | — | 1991-01-16 | — | — | EP | disclosed |
| EP-0299044-A1 | DRY REAGENT DELIVERY SYSTEM | TECHNIMED CORPORATION (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4774192-A | A dry reagent delivery system with membrane having porosity gradient | TECHNIMED CORPORATION (US) | 1988-09-27 | — | — | US | disclosed |
| WO-1988005912-A1 | DRY REAGENT DELIVERY SYSTEM | TECHNIMED CORPORATION (US) | 1988-08-11 | — | — | WO | disclosed |
| US-4373087-A | P-PHENYLENEDIAMINE, TEREPHTHALIC ACID | UBE INDUSTRIES LTD. (JP) | 1983-02-08 | — | — | US | disclosed |
| US-4153512-A | PROPAGATING MICROORGANISMS USING GRADUATED CONCENTRATION SERIES, POLYBINYLPYRROLIDONE BULKING AGENT | FISHER SCIENTIFIC COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4017261-A | Biological diagnostic test strip and method of producing same | LACHEMA, NARODNI PODNIK (CS) | 1977-04-12 | — | — | US | disclosed |