Orthotolidine

Orthotolidine

SCHEMBL867121

Cc1cc(-c2ccc(N)c(C)c2)ccc1N.Cl.Cl

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Orthotolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 10/20 0.94
TDP1 Q9NUW8 9/20 0.94
ALDH1A1 P00352 9/20 0.94
TSHR P16473 5/20 0.94
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPK1 P28482 3/20 0.50
HSD17B10 Q99714 4/20 0.46
ALOX15 P16050 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
PKM P14618 1/20 0.46
TP53 P04637 3/20 0.46
S100B P04271 1/20 0.45
SKP2 Q13309 1/20 0.43
APP P05067 1/20 0.43
HPGD P15428 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orthotolidine SCHEMBL3466480 1.00 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL38664709 1.00 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL864763 0.97 CYP3A4 (0.90) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL29386552 0.97 CYP3A4 (1.00) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL49414 0.97 CYP3A4 (1.00) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL29365329 0.97 CYP3A4 (1.00) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL11189493 0.94 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1
SCHEMBL8954009 0.94 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL20547383 0.94 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1
Orthotolidine SCHEMBL22129692 0.94 CYP3A4 (0.94) CYP3A4TDP1ALDH1A1TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2799118-B1 FIRE EXTINGUISHING COMPOSITION CONTAINING TRANSITION METAL COMPOUND XIAN WESTPEACE FIRE TECH CO LTD (CN) 2019-07-10 EP claimed
US-9717939-B2 Fire extinguishing composition containing transition metal compound XI'AN WESTPEACE FIRE TECHNOLOGY CO., LTD (CN) 2017-08-01 US claimed
US-20150190664-A1 FIRE EXTINGUISHING COMPOSITION CONTAINING TRANSITION METAL COMPOUND XI'AN J&R FIRE FIGHTING EQUIPMENT CO., LTD. (CN) 2015-07-09 US claimed
EP-2799118-A1 FIRE EXTINGUISHING COMPOSITION CONTAINING TRANSITION METAL COMPOUND Xi'an J&R Fire Fighting Equipment Co., Ltd. (CN) 2014-11-05 EP claimed
US-20130146439-A1 PHOTO-INDUCED REDUCTION-OXIDATION CHEMISTRY OF CARBON NANOTUBES ROSTOVTSEV VSEVOLOD (US) 2013-06-13 US claimed
US-8038853-B2 Photo-induced reduction-oxidation chemistry of carbon nanotubes E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-10-18 US claimed
EP-1274999-B1 METHOD AND TEST STRIP OF DETECTING OXIDIZING ADULTERANT IN URINE BRANAN MEDICAL CORP (US) 2010-11-17 EP claimed
US-20080308407-A1 PHOTO-INDUCED REDUCTION-OXIDATION CHEMISTRY OF CARBON NANOTUBES E. I. DU PONT DE NEMOURS AND COMPANY 2008-12-18 US claimed
US-6689618-B1 CONTACTING ALIQUOT OF BODY FLUID WITH DRY TEST STRIP COMPRISING BENZIDINE DERIVATIVE, DETERMINING PRESENCE OF PYRIDINIUM CHLOROCHROMATE OR SODIUM NITRITE BY OBSERVING COLOR CHANGE, IN WHICH DIFFERENT COLOR RESULTS FOR EACH ADULTERANT BRANAN MEDICAL CORP. 2004-02-10 US claimed
US-20250180952-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2025-06-05 US disclosed
EP-4493638-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2025-01-22 EP disclosed
CN-118389296-A Leuconostoc mesenteroides strain and fruiting body cultivation method and application 河西学院 2024-07-26 CN disclosed
CN-118027412-A Photo-alignment material 罗利克技术有限公司 2024-05-14 CN disclosed
WO-2023174773-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2023-09-21 WO disclosed
US-4483929-A Liposomes with glycolipid-linked antibodies LIPOSOME TECHNOLOGY INCORPORATED (US) 1984-11-20 US disclosed
US-4444879-A Immunoassay with article having support film and immunological counterpart of analyte SCIENCE RESEARCH CENTER, INC. (US) 1984-04-24 US disclosed
US-4427783-A Immunoassay of thymosin α1 HOFFMANN-LA ROCHE INC. (US) 1984-01-24 US disclosed
EP-0046185-A1 Process for the preparation of substituted 4,4'-diamino-diphenylene BASF Aktiengesellschaft (DE) 1982-02-24 EP disclosed
EP-0029917-A1 Indicator composition and test device containing amine oxide MILES LABORATORIES, INC. (US) 1981-06-10 EP disclosed
EP-0029926-A1 A composition and a test device based on a benzidine-type indicator for detecting the presence of a constituent in a test sample MILES LABORATORIES, INC. (US) 1981-06-10 EP disclosed