Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1000866 | 0.96 | CES1 (0.41) | TSHRLMNACES1GBA1CES2 | |
| Hydrochloric Acid SCHEMBL4946144 | 0.96 | CES1 (0.41) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL21882 | 0.96 | — | — | |
| Iodide SCHEMBL7869089 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL4849581 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL1406213 | 0.92 | CES2 (0.46) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL747847 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL10591515 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL11531992 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 | |
| SCHEMBL11527395 | 0.92 | TSHR (0.43) | TSHRLMNACES1GBA1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924793-B | Siloxane-modified thermoplastic material and preparation method thereof | SHENZHEN CITY SQUARE SILICONE MATERIALS CO LTD | 2014-03-12 | — | — | CN | disclosed |
| CN-102924793-A | Siloxane-modified thermoplastic material and preparation method thereof | SHENZHEN CITY SQUARE SILICONE MATERIALS CO LTD | 2013-02-13 | — | — | CN | disclosed |
| US-7842129-B2 | Lacquer formulation for improving surface properties | EVONIK DEGUSSA GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20050282022-A1 | Coating formulation for improving surface properties | DEGUSSA AG (DE) | 2005-12-22 | — | — | US | disclosed |
| EP-1440123-A1 | THERMOPLASTIC SILICONE ELASTOMERS FROM COMPATIBILIZED POLYAMIDE RESINS | Dow Corning Corporation (US) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003035759-A1 | THERMOPLASTIC SILICONE ELASTOMERS FROM COMPATIBILIZED POLYAMIDE RESINS | DOW CORNING CORPORATION (US) | 2003-05-01 | — | — | WO | disclosed |
| EP-1274801-A2 | THERMOPLASTIC SILICONE POLYAMIDE ELASTOMERS | Dow Corning Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| CN-1373793-A | Thermoplastic resins toughened with silicon rubber | DOW CORNING (US) | 2002-10-09 | — | — | CN | disclosed |
| EP-1214377-A1 | WITH SILICONE RUBBER TOUGHENED THERMOPLASTIC RESINS | DOW CORNING CORPORATION (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-1153079-A1 | FIRE RESISTANT THERMOPLASTIC SILICONE VULCANIZATES | DOW CORNING CORPORATION (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2001072903-A2 | THERMOPLASTIC SILICONE POLYAMIDE ELASTOMERS | DOW CORNING CORPORATION (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001018116-A1 | WITH SILICON RUBBER TOUGHENED THERMOPLASTIC RESINS | DOW CORNING CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2000046291-A1 | FIRE RESISTANT THERMOPLASTIC SILICONE VULCANIZATES | DOW CORNING CORPORATION (US) | 2000-08-10 | — | — | WO | disclosed |