Valine

Valine

SCHEMBL351273

CC(C)[C@H](N)C(=O)O.Cl.[SbH3]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 known ✓ P27487 1/20 0.38
GABRP known ✓ O00591 2/20 0.35
GABRD known ✓ O14764 2/20 0.35
GABRA1 known ✓ P14867 2/20 0.35
GABRB1 known ✓ P18505 2/20 0.35
GABRG2 known ✓ P18507 2/20 0.35
GABRB3 known ✓ P28472 2/20 0.35
GABRA5 known ✓ P31644 2/20 0.35
GABRA3 known ✓ P34903 2/20 0.35
GABRA2 known ✓ P47869 2/20 0.35
GABRB2 known ✓ P47870 2/20 0.35
GABRA4 known ✓ P48169 2/20 0.35
GABRE known ✓ P78334 2/20 0.35
GABRA6 known ✓ Q16445 2/20 0.35
GABRG1 known ✓ Q8N1C3 2/20 0.35
GABRG3 known ✓ Q99928 2/20 0.35
GABRQ known ✓ Q9UN88 2/20 0.35
PTGS1 known ✓ P23219 1/20 0.35
SLC7A5 Q01650 2/20 0.88
SLC1A3 P43003 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valine SCHEMBL16893971 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53
Valine SCHEMBL3402665 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53
Valine SCHEMBL14637050 0.97
Valine SCHEMBL132740 0.97
Valine SCHEMBL245432 0.97
Valine SCHEMBL23777447 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53
Valine SCHEMBL10775583 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53
Valine SCHEMBL9439900 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53
Valine SCHEMBL1227071 0.97
Valine SCHEMBL3426769 0.97 SLC7A5 (0.94) SLC7A5SLC1A3SLC1A2SLC1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4079090-A Preparation of trichloromethyl-trifluoro methyl-benzenes BAYER AKTIENGESELLSCHAFT (DT) 1978-03-14 US claimed
US-20230256661-A1 TWO-PART MASTERBATCH, PACKAGING ARTICLES, AND METHODS SWIMC LLC (US) 2023-08-17 US disclosed
EP-4188991-A1 TWO-PART MASTERBATCH, PACKAGING ARTICLES, AND METHODS Swimc LLC (US) 2023-06-07 EP disclosed
CN-116157451-A Two part masterbatch, packaging article and method SWIMC有限公司 2023-05-23 CN disclosed
US-20230124025-A1 COMPOSITIONS AND METHODS FOR BIODEGRADABLE, BIOMASS-BASED POLYESTERS UNIVERSITY OF MASSACHUSETTS 2023-04-20 US disclosed
WO-2022026412-A1 TWO-PART MASTERBATCH, PACKAGING ARTICLES, AND METHODS SWIMC LLC (US) 2022-02-03 WO disclosed
CN-110770133-B Discharge container 龟甲万株式会社 2021-11-05 CN disclosed
US-11155398-B2 Dispensing container KIKKOMAN CORPORATION (JP) 2021-10-26 US disclosed
US-10618718-B2 Oxygen scavengers APG Polytech, LLC (US) 2020-04-14 US disclosed
US-20200062476-A1 FOOD AND BEVERAGE COMPOSITION CONTAINED IN DOUBLE-LAYERED CONTAINER KIKKOMAN CORPORATION (JP) 2020-02-27 US disclosed
US-20040068055-A1 Multilayered package with barrier properties VALSPAR SOURCING INC. 2004-04-08 US disclosed
US-20030039779-A1 Packaging for food, beverage SWIMC LLC 2003-02-27 US disclosed
EP-1167214-A2 Oxygen scavenging composition for multilayer preform and container CONTINENTAL PET TECHNOLOGIES, INC. (US) 2002-01-02 EP disclosed
US-5759653-A Oxygen scavenging composition for multilayer preform and container CONTINENTAL PET TECHNOLOGIES, INC. (US) 1998-06-02 US disclosed
EP-0797628-A1 OXYGEN SCAVENGING COMPOSITION FOR MULTILAYER PREFORM AND CONTAINER CONTINENTAL PET TECHNOLOGIES, INC. (US) 1997-10-01 EP disclosed
WO-1996018685-A1 OXYGEN SCAVENGING COMPOSITION FOR MULTILAYER PREFORM AND CONTAINER CONTINENTAL PET TECHNOLOGIES, INC. (US) 1996-06-20 WO disclosed
US-5420099-A Sulfanomide herbicides SHELL RESEARCH LIMITED (GB) 1995-05-30 US disclosed
EP-0549079-A1 Sulphonamide herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1993-06-30 EP disclosed
US-4401644-A HYDROLYSIS OF ANTIMONY TRICHLORIDE IN THE PRESENCE OF AN OXIDIZER BUREAU DE RECHERCHES GEOLOGIQUES ET MINIERES (FR) 1983-08-30 US disclosed
US-4391792-A ORTHORHOMBIC ANTIMONY TRIOXIDE FROM ANTIMONY TRICHLORIDE BUREAU DE RECHERCHES GEOLOGIQUES ET MINIERES (FR) 1983-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10618718-B2 Oxygen scavengers LPO, GPX4, GPX1 DPP4 4219/4885GABRP 4222/4885GABRD 4589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.