Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA known ✓ | P17252 | 1/20 | 0.50 |
| ▸ | PRKCE known ✓ | Q02156 | 1/20 | 0.50 |
| ▸ | PRKCQ known ✓ | Q04759 | 1/20 | 0.50 |
| ▸ | PRKCD known ✓ | Q05655 | 1/20 | 0.50 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | PAM | P19021 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7018660 | 1.00 | DGKA (0.68) | DGKACYP1A2PAMTSHRMAPT | |
| Hydrochloric Acid SCHEMBL9753076 | 0.98 | DGKA (0.72) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL31352662 | 0.98 | DGKA (0.71) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL37297 | 0.98 | DGKA (0.71) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL19252993 | 0.95 | DGKA (0.68) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL2309907 | 0.95 | DGKA (0.68) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL8375548 | 0.95 | DGKA (0.75) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL454 | 0.95 | DGKA (0.75) | DGKACYP1A2PAMTSHRMAPT | |
| Hexane SCHEMBL2349171 | 0.95 | DGKA (0.75) | DGKACYP1A2PAMTSHRMAPT | |
| SCHEMBL1506909 | 0.95 | DGKA (0.68) | DGKACYP1A2PAMTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1732161-A | 1,3-diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARM INC (US) | 2006-02-08 | — | — | CN | claimed |
| CN-1208319-C | 2-oxo-1-pyrrolidine derivatives, preparation method and use thereof | UCB SA (BE) | 2005-06-29 | — | — | CN | claimed |
| CN-107406464-B | Arginase inhibitor and its therapeutical uses | 昂科艾伦迪治疗法股份公司 | 2019-03-19 | — | — | CN | disclosed |
| CN-104876955-B | Arginase inhibitor and its treatment use | 马尔斯公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-107406464-A | Arginase inhibitor and its therapeutical uses | 昂科艾伦迪治疗法股份公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-104876955-A | Inhibitors Of Arginase And Their Therapeutic Applications | MARS INC | 2015-09-02 | — | — | CN | disclosed |
| CN-103068830-A | Arginase inhibitors and therapeutic uses thereof | MARS INC | 2013-04-24 | — | — | CN | disclosed |
| EP-2152674-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2010-02-17 | — | — | EP | disclosed |
| CN-100579957-C | Novel arylamidine derivative or salt thereof | TOYAMA CHEMICAL CO LTD | 2010-01-13 | — | — | CN | disclosed |
| CN-101611008-A | C3A receptor modulators and methods of use thereof | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-12-23 | — | — | CN | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |
| CN-1224718-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 1999-08-04 | — | — | CN | disclosed |
| CN-1043647-C | Novel peptide compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-06-16 | — | — | CN | disclosed |
| CN-1182419-A | Novel pyridine derivatives and medicine containing the same as active ingredient | SS PHARMACEUTICAL CO (JP) | 1998-05-20 | — | — | CN | disclosed |
| CN-1165815-A | Phenol compound and process for preparing the same | TANABE SEIYAKU CO (JP) | 1997-11-26 | — | — | CN | disclosed |
| CN-1120047-A | New peptide compound and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-04-10 | — | — | CN | disclosed |
| CN-1030607-C | Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their prepn. and use | SANKYO CO (JP) | 1996-01-03 | — | — | CN | disclosed |
| CN-1066660-A | Peptide compounds and process for preparing same | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-12-02 | — | — | CN | disclosed |
| CN-1051360-A | Have agaist allergic symptoms and the active new tetracyclic compound of anti-asthma, its preparation and application | SANKYO CO (JP) | 1991-05-15 | — | — | CN | disclosed |
| CN-86101268-A | The preparation method of new peptidase inhibitors | — | 1987-02-04 | — | — | CN | disclosed |