Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.31 |
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.31 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.30 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.30 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234571 | 0.98 | CALM1 (0.41) | CALM1KDM4ECYP3A4MAPTTAAR1 | |
| SCHEMBL3837766 | 0.96 | CALM1 (0.39) | CALM1KDM4ECYP3A4MAPTTAAR1 | |
| Fluoride SCHEMBL1131271 | 0.96 | CALM1 (0.39) | CALM1KDM4ECYP3A4MAPTTAAR1 | |
| Hydrochloric Acid SCHEMBL3683526 | 0.85 | KDM4E (0.33) | CALM1KDM4ECYP3A4MAPT | |
| SCHEMBL4576265 | 0.81 | CALM1 (0.31) | CALM1 | |
| Fluoride SCHEMBL1130979 | 0.80 | MAOA (0.35) | TAAR1MAOAMAOB | |
| SCHEMBL6209507 | 0.77 | TP53 (0.38) | TAAR1MAOAMAOBADRA2AADRA1A | |
| Fluoride SCHEMBL1131527 | 0.77 | HTR2A (0.39) | MAOAMAOBADRA1A | |
| SCHEMBL4576935 | 0.76 | CALM1 (0.41) | CALM1CYP3A4TAAR1LMNAMAOA | |
| (Chloromethyl)Benzene SCHEMBL6208839 | 0.75 | TP53 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329312-B1 | POLYMERIZATION CATALYSTS FOR OLEFINS USING METALLOCENES AND ORGANOMETALLIC COCATALYSTS | PHILLIPS PETROLEUM COMPANY | 2001-12-11 | — | — | US | claimed |
| EP-0798315-B1 | Process for preparing highly active, stable metallocene catalyst systems, and catalyst compositions prepared according therewith | WITCO GMBH (DE) | 1997-10-29 | — | — | EP | claimed |
| EP-1294565-B1 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENE AND LOW DENSITY POLYETHYLENE BLENDS | UNIVATION TECH LLC (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-1373404-B1 | POLYETHYLENE BLENDS | UNIVATION TECH LLC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1299470-B1 | VERY LOW DENSITY POLYETHYLENE AND HIGH DENSITY POLYETHYLENE BLENDS | UNIVATION TECH LLC (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1810992-A1 | Polyethylene blends | Univation Technologies, LLC (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7220801-B2 | Metallocene-produced very low density polyethylenes or linear low density polyethylenes as impact modifiers | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060276594-A1 | Very low density polyethylene blends | UNIVATION TECHNOLOGIES, LLC (US) | 2006-12-07 | — | — | US | disclosed |
| US-7135526-B2 | Very low density polyethylene and high density polyethylene blends | UNIVATION TECHNOLOGIES, LLC (US) | 2006-11-14 | — | — | US | disclosed |
| US-7125933-B2 | Very low density polyethylene blends | UNIVATION TECHNOLOGIES, LLC (US) | 2006-10-24 | — | — | US | disclosed |
| US-6953828-B2 | Polymeric membrane compositions | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2005-10-11 | — | — | US | disclosed |
| EP-1325073-A2 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENES | ExxonMobil Chemical Patents Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2003033585-A1 | POLYMERIC MEMBRANE COMPOSITIONS | EXXONMOBILE CHEMICAL PATENTS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| EP-1299470-A1 | VERY LOW DENSITY POLYETHYLENE AND HIGH DENSITY POLYETHYLENE BLENDS | ExxonMobil Chemical Patents Inc. (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-1294565-A2 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENE AND LOW DENSITY POLYETHYLENE BLENDS | ExxonMobil Chemical Patents Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2003000790-A1 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENES OR LINEAR LOWDENSITY POLYETHYLENES AS IMPACT MODIFIERS | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
| WO-2002000436-A2 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENE AND LOW DENSITY POLYETHYLENE BLENDS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001098409-A1 | VERY LOW DENSITY POLYETHYLENE AND HIGH DENSITY POLYETHYLENE BLENDS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001098372-A2 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENES | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001098406-A2 | POLYETHYLENE BLENDS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2001-12-27 | — | — | WO | disclosed |