Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.47 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13599744 | 0.78 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL410374 | 0.78 | ZDHHC20 (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL6684683 | 0.78 | TSHR (0.50) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL151622 | 0.76 | ZDHHC20 (0.50) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL27985635 | 0.75 | ALDH1A1 (0.58) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL20262206 | 0.75 | TSHR (0.52) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL21798971 | 0.74 | SMN1; SMN2 (0.40) | TSHRALDH1A1GAA | |
| SCHEMBL19300353 | 0.74 | ZDHHC20 (0.48) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL28433367 | 0.74 | ZDHHC20 (0.48) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 | |
| SCHEMBL10661514 | 0.74 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2TSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103959174-B | Alcohol-soluble hole transport materials for organic photoconductor coatings | 惠普发展公司，有限责任合伙企业 | 2017-06-09 | — | — | CN | disclosed |
| EP-2795406-B1 | ALCOHOL-SOLUBLE HOLE TRANSPORT MATERIALS FOR ORGANIC PHOTOCONDUCTOR COATINGS | HEWLETT PACKARD DEVELOPMENT CO LP (US) | 2017-02-08 | — | — | EP | disclosed |
| US-9482970-B2 | Organic photoconductors having protective coatings with nanoparticles | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2016-11-01 | — | — | US | disclosed |
| EP-2831674-B1 | ORGANIC PHOTOCONDUCTORS HAVING PROTECTIVE COATINGS WITH NANOPARTICLES | HEWLETT PACKARD DEVELOPMENT CO (US) | 2016-03-30 | — | — | EP | disclosed |
| US-9235147-B2 | Alcohol-soluble hole transport materials for organic photoconductor coatings | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9188884-B2 | Charge transport layer for organic photoconductors | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2831674-A1 | ORGANIC PHOTOCONDUCTORS HAVING PROTECTIVE COATINGS WITH NANOPARTICLES | Hewlett-Packard Development Company, L.P. (US) | 2015-02-04 | — | — | EP | disclosed |
| US-20140349227-A1 | ORGANIC PHOTOCONDUCTORS HAVING PROTECTIVE COATINGS WITH NANOPARTICLES | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2014-11-27 | — | — | US | disclosed |
| US-20140322638-A1 | ALCOHOL-SOLUBLE HOLE TRANSPORT MATERIALS FOR ORGANIC PHOTOCONDUCTOR COATINGS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2014-10-30 | — | — | US | disclosed |
| EP-2795406-A1 | ALCOHOL-SOLUBLE HOLE TRANSPORT MATERIALS FOR ORGANIC PHOTOCONDUCTOR COATINGS | Hewlett-Packard Development Company, L.P. (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7219989-B2 | Overcoat composition for image recording materials | EASTMAN KODAK COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060223908-A1 | Charge adhesive protective ink jet inks | EASTMAN KODAK COMPANY | 2006-10-05 | — | — | US | disclosed |
| WO-2006104815-A2 | CHARGE ADHESIVE PROTECTIVE INK JET INKS | EASTMAN KODAK COMPANY (US) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006052706-A1 | INK JET INK COMPOSITION | EASTMAN KODAK COMPANY (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006052973-A1 | INKJET COMPOSITION CONTAINING MICROGEL PARTICLES | EASTMAN KODAK COMPANY (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20060100306-A1 | Ink jet ink composition | EASTMAN KODAK COMPANY | 2006-05-11 | — | — | US | disclosed |
| US-20060100307-A1 | Ink jet composition containing microgel particles | EASTMAN KODAK COMPANY | 2006-05-11 | — | — | US | disclosed |
| US-20040202838-A1 | Overcoat composition for image recording materials | EASTMAN KODAK COMPANY | 2004-10-14 | — | — | US | disclosed |
| US-20040097615-A1 | Ink composition for ink jet printing | EASTMAN KODAK COMPANY | 2004-05-20 | — | — | US | disclosed |
| EP-1413453-A2 | Imaged recording materials having a transparent overcoat composition | EASTMAN KODAK COMPANY (US) | 2004-04-28 | — | — | EP | disclosed |