Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.39 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.32 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431920 | 0.98 | CYP3A4 (0.40) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| SCHEMBL739126 | 0.85 | CYP3A4 (0.45) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| Diphenylamine SCHEMBL6528579 | 0.82 | ALDH1A1 (0.46) | CYP3A4TSHRALDH1A1KDM4EGAA | |
| SCHEMBL11298336 | 0.77 | CYP3A4 (0.56) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL309540 | 0.77 | CYP3A4 (0.59) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL529931 | 0.77 | CYP3A4 (0.59) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL29566187 | 0.77 | CYP3A4 (0.59) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| SCHEMBL11119368 | 0.74 | CYP3A4 (0.40) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| SCHEMBL33944 | 0.74 | CYP3A4 (0.62) | CYP3A4TSHRPIK3CAALDH1A1KDM4E | |
| SCHEMBL29384787 | 0.74 | CYP3A4 (0.62) | CYP3A4TSHRPIK3CAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409146-B | Continuous preparation process of vanillin | 南通亚香食品科技有限公司 | 2023-07-07 | — | — | CN | claimed |
| CN-114685318-A | Preparation method of N- (carboxymethyl aminocarbonyl) -4,4' -bis (dimethylamino) diphenylamine sodium salt | 苏州络森生物科技有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-112409146-A | Continuous preparation process of vanillin | 南通亚香食品科技有限公司 | 2021-02-26 | — | — | CN | claimed |
| CN-111747836-A | Production process and reaction equipment for synthesizing vanillin from 4-methyl guaiacol | 昆山亚香香料股份有限公司 | 2020-10-09 | — | — | CN | claimed |
| CN-112409146-B | Continuous preparation process of vanillin | 南通亚香食品科技有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-114685318-A | Preparation method of N- (carboxymethyl aminocarbonyl) -4,4' -bis (dimethylamino) diphenylamine sodium salt | 苏州络森生物科技有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-112409146-A | Continuous preparation process of vanillin | 南通亚香食品科技有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111747836-A | Production process and reaction equipment for synthesizing vanillin from 4-methyl guaiacol | 昆山亚香香料股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| US-20120288944-A1 | Molecularly Imprinted Polymer Sensing Method | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-11-15 | — | — | US | disclosed |
| US-8241575-B2 | Molecularly imprinted polymer sensor device | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-14 | — | — | US | disclosed |
| US-20090197297-A1 | Molecularly Imprinted Polymer Sensor Device | JOHNS HOPKINS UNIVERSITY | 2009-08-06 | — | — | US | disclosed |
| US-4581223-A | STAINS FOR BLOOD COUNTS | CYTOCOLOR INC., A CORP OF OH | 1986-04-08 | — | — | US | disclosed |
| US-4239894-A | DYES FOR SYNTHETIC AND NATURAL FIBERS | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4093640-A | HAIR DYES | L'OREAL (FR) | 1978-06-06 | — | — | US | disclosed |
| US-3984443-A | Indamines for dyeing keratinic fibers | L'OREAL (FR) | 1976-10-05 | — | — | US | disclosed |