Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL30539261 | 1.00 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL28403643 | 1.00 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL3986143 | 1.00 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL3406297 | 0.96 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL8059260 | 0.96 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL15845959 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL4748243 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL434089 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL1146 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15LMNA | |
| Trolamine SCHEMBL27835743 | 0.92 | MAPT (0.39) | MAPTKDM4ESMN1; SMN2ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3340 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026106819-A1 | MICROCARRIERS WITH IMPROVED REHYDRATION | CORNING INCORPORATED (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4646470-A1 | SOLID FABRIC CARE FORMULATION | S H Kelkar and Company Limited (IN) | 2025-11-12 | — | — | EP | claimed |
| CN-120025379-A | Selenium molybdate compound constructed by rigid binary/polybasic carboxylic acid ligand, and preparation method and application thereof | 长江师范学院 | 2025-05-23 | — | — | CN | claimed |
| CN-120004697-A | Preparation method of OrgVO material and application of OrgVO material as secondary battery anode material | 同济大学 | 2025-05-16 | — | — | CN | claimed |
| CN-119931985-A | Enzyme catalytic synthesis method of aminotransferase and remigem intermediate | 江苏阿尔法药业股份有限公司 | 2025-05-06 | — | — | CN | claimed |
| EP-4022124-B1 | ENVIRONMENTALLY DYEING PROCESS FOR CELLULOSIC TEXTILE PRODUCTS | BURSALI TEKSTIL SANAYI VE TICARET ANONIM SIRKETI (TR) | 2025-04-30 | — | — | EP | claimed |
| CN-119681498-A | Soldering tin wire scaling powder for nickel piece soldering and preparation method thereof | 云南锡业新材料有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119505809-A | Multi-element eutectic phase-change material, phase-change slow-release salt-storage filler and preparation method | 长安大学 | 2025-02-25 | — | — | CN | claimed |
| CN-119431894-A | Temperature-control slow-release salt-storage filler and preparation method thereof | 长安大学 | 2025-02-14 | — | — | CN | claimed |
| US-12221645-B2 | Processes for producing reduced coenzyme Q10 | KINGDOMWAY BIOTECHNOLOGY (JIANGSU) CO., LTD. (CN) | 2025-02-11 | — | — | US | claimed |
| EP-0101979-B1 | DIAGNOSTIC DEVICE AND ITS USE | Eisai Co., Ltd. (JP) | 1988-03-30 | — | — | EP | claimed |
| US-4724204-A | CARRIER, REDOX DYESTUFF; DETECTION OF MALIGNANT GROWTHS IN FEMALE GENITAL AREA | MEDI-PHARMA VERTRIEBSGESELLSCHAFT MBH (DE) | 1988-02-09 | — | — | US | claimed |
| EP-0225874-A1 | FLUXING AGENT AND SOLDERING PROCESS | YTKEMISKA INSTITUTET (SE) | 1987-06-24 | — | — | EP | claimed |
| US-4594452-A | Process for the preparation of anhydrous N-(3-chloro-2-hydroxypropyl) trialkylammonium salts | ALLIED CORPORATION (US) | 1986-06-10 | — | — | US | claimed |
| WO-1986000844-A1 | FLUXING AGENT AND SOLDERING PROCESS | YTKEMISKA INSTITUTET (SE) | 1986-02-13 | — | — | WO | claimed |
| EP-0149490-A2 | Presensitized plate having an anodized aluminum base with an improved hydrophilic layer | FUJI PHOTO FILM CO., LTD. (JP) | 1985-07-24 | — | — | EP | claimed |
| EP-0029243-B1 | METHOD FOR CLEANING AND SANITIZING THE INTERIOR OF PIPELINES | THE DOW CHEMICAL COMPANY (US) | 1985-05-22 | — | — | EP | claimed |
| US-4512913-A | BY REACTING GROUP II WATER SOLUBLE METAL SALT WITH ALUMINUM CHLOROHYDRATE COMPLEX | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1985-04-23 | — | — | US | claimed |
| US-4267260-A | Developer for lithographic printing plate | MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) | 1981-05-12 | — | — | US | claimed |
| US-3964500-A | Lusterizing shampoo containing a polysiloxane and a hair-bodying agent | LEVER BROTHERS COMPANY (US) | 1976-06-22 | — | — | US | claimed |