Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.47 |
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 known ✓ | P09237 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 5/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.39 |
| ▸ | FPR2 | P25090 | 4/20 | 0.38 |
| ▸ | TXN | P10599 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10681958 | 1.00 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27564991 | 1.00 | — | — | |
| SCHEMBL189942 | 0.97 | — | — | |
| Bromide SCHEMBL5133738 | 0.95 | — | — | |
| SCHEMBL29212737 | 0.89 | F2RL1 (0.41) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| SCHEMBL4304273 | 0.89 | F2RL1 (0.41) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| Pyrrole SCHEMBL28392514 | 0.87 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| Acetic Acid SCHEMBL27677340 | 0.85 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| SCHEMBL27695954 | 0.83 | FPR2 (0.42) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 | |
| SCHEMBL4301987 | 0.83 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101932343-A | Superabsorbent polymer compositions having a triggering composition | EVONIK STOCKHAUSEN INC | 2010-12-29 | — | — | CN | disclosed |
| WO-2009048157-A1 | SURFACE TREATMENT METHOD FOR WATER-ABSORBENT RESIN | NIPPON SHOKUBAI CO., LTD. (JP) | 2009-04-16 | — | — | WO | disclosed |
| EP-0376151-A2 | Process for dyeing textile materials with pigment dyes | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-04 | — | — | EP | disclosed |
| EP-0292637-A1 | Improved cathodic electrocoating composition compounded with latex binder | THE GLIDDEN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| EP-0292638-A1 | Improved cathodic electrocoating composition compounded with latex binder | THE GLIDDEN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| US-4525260-A | ACRYLIC RESINS CONTAINING AMINO GROUPS AND HAVING LOW MICROGEL CONTENT | SCM CORPORATION (US) | 1985-06-25 | — | — | US | disclosed |
| US-4511446-A | Cathodic electrocoating composition compounded with latex binder for enhanced gloss retention | SCM CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0132698-A2 | Improved cathodic electrocoating composition compounded with latex binder | THE GLIDDEN COMPANY (formerly known as ATKEMIX EIGHT INC.) (US) | 1985-02-13 | — | — | EP | disclosed |
| WO-1985000390-A1 | IMPROVED CATHODIC ELECTROCOATING COMPOSITION COMPOUNDED WITH LATEX BINDER | SCM CORPORATION (US) | 1985-01-31 | — | — | WO | disclosed |