Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.40 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.40 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.32 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.32 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.32 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.32 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.32 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.32 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.32 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274491 | 0.85 | ACHE (0.40) | ACHEBCHEHTR2ACHRM2CHRM1 | |
| SCHEMBL2275700 | 0.78 | HTR2A (0.37) | ACHEBCHEHTR2A | |
| SCHEMBL27619062 | 0.77 | ACHE (0.42) | ACHEBCHEHTR2ACHRM2CHRM1 | |
| SCHEMBL313685 | 0.77 | ACHE (0.55) | ACHEBCHEHTR2AMEN1KMT2A | |
| SCHEMBL815385 | 0.76 | ACHE (0.41) | ACHEBCHEHTR2ACHRM2CHRM1 | |
| SCHEMBL2672463 | 0.76 | BCHE (0.41) | ACHEBCHEHTR2ACYP3A4CYP2D6 | |
| SCHEMBL30638595 | 0.76 | ACHE (0.41) | ACHEBCHEHTR2ACHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL2274495 | 0.75 | ACHE (0.41) | ACHEBCHEHTR2ACHRM2CHRM1 | |
| SCHEMBL27741321 | 0.72 | HTR2A (0.41) | ACHEBCHEHTR2A | |
| SCHEMBL28262727 | 0.72 | HTR2A (0.41) | ACHEBCHEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629245-B2 | Polyethylene compositions, wire and cables, and methods for making the same | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2023-04-18 | — | — | US | disclosed |
| US-20210309842-A1 | Polyethylene Compositions, Wire and Cables, and Methods for Making the Same | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3814390-A2 | POLYETHYLENE COMPOSITIONS, WIRES AND CABLES, AND METHODS FOR MAKING THE SAME | ExxonMobil Chemical Patents Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| US-RE40751-E1 | Polymerization catalyst systems comprising substituted hafnocenes | UNIVATION TECHNOLOGIES, LLC (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1694502-A4 | HIGH TEAR FILMS FROM HAFNOCENE CATALYZED POLYETHYLENES | UNIVATION TECH LLC (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7179876-B2 | Such as bis(propylcyclopentadienyl) hafnium dichloride, reacting ethylene and a comonomer at given ethylene partial pressure range, and extruding into a film of given secant modulus, dart impact strength | UNIVATION TECHNOLOGIES, LLC (US) | 2007-02-20 | — | — | US | disclosed |
| US-7172816-B2 | High tear films from hafnocene catalyzed polyethylenes | UNIVATION TECHNOLOGIES, LLC (US) | 2007-02-06 | — | — | US | disclosed |
| EP-1694502-A1 | HIGH TEAR FILMS FROM HAFNOCENE CATALYZED POLYETHYLENES | Univation Technologies, LLC (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20050215716-A1 | Such as bis(propylcyclopentadienyl) hafnium dichloride, film of given secant modulus, dart impact strength | SZUL JOHN F | 2005-09-29 | — | — | US | disclosed |
| US-6936675-B2 | metallocene is represented by the formula: CpHfX2, wherein each X is independently selected from the group consisting of fluorine, chlorine, iodine, bromine, and Cp selected from the fluorene, cyclopentadienyl, indenyl; high impact strength | UNIVATION TECHNOLOGIES, LLC (US) | 2005-08-30 | — | — | US | disclosed |
| US-20050171283-A1 | Such as bis(propylcyclopentadienyl) hafnium dichloride, reacting ethylene and a comonomer at given ethylene partial pressure range, and extruding into a film of given secant modulus, dart impact strength | EXXONMOBIL CHEMICAL PATENTS INC. | 2005-08-04 | — | — | US | disclosed |
| WO-2005061225-A1 | HIGH TEAR FILMS FROM HAFNOCENE CATALYZED POLYETHYLENES | UNIVATION TECHNOLOGIES, LLC. (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050058847-A1 | metallocene is represented by the formula: CpHfX2, wherein each X is independently selected from the group consisting of fluorine, chlorine, iodine, bromine, and Cp selected from the fluorene, cyclopentadienyl, indenyl; high impact strength | UNIVATION TECHNOLOGIES, LLC | 2005-03-17 | — | — | US | disclosed |
| US-6242545-B1 | POLYMERIZING OLEFIN(S) IN THE PRESENCE OF A HAFNIUM METALLOCENE CATALYST COMPOUND HAVING A CYCLOPENTADIENYL LIGAND OR DERIVATIVE WITH AT LEAST ONE LINEAR OR ISO ALKYL GROUP ACTIVATOR | UNIVATION TECHNOLOGIES | 2001-06-05 | — | — | US | disclosed |