Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.45 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.44 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.44 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.44 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.44 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29389905 | 1.00 | CYP2D6 (0.98) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| SCHEMBL29356135 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| SCHEMBL178013 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| Nitric Acid SCHEMBL3871762 | 0.92 | CYP2D6 (0.86) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| SCHEMBL178039 | 0.87 | KMT2A (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| SCHEMBL29419477 | 0.87 | KMT2A (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| Stylopine SCHEMBL23524621 | 0.87 | CYP2D6 (0.77) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| SCHEMBL9882661 | 0.82 | CYP2D6 (0.71) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| Protopine SCHEMBL29613725 | 0.82 | CYP2D6 (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E | |
| Allocryptopine SCHEMBL673252 | 0.81 | CYP2D6 (1.00) | CYP2D6CYP2C19CYP3A4TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773445-B1 | Diagnostic methods | GRIFFITH UNIVERSITY | 2023-10-03 | — | — | US | disclosed |
| US-20210069180-A1 | METHODS FOR TREATING CHRONIC FATIGUE SYNDROME AND MYALGIC ENCEPHALOMYELITIS | GRIFFITH UNIVERSITY (AU) | 2021-03-11 | — | — | US | disclosed |
| CN-110354120-A | The application of protopine or its salt in preparation prevention and treatment cerebrovascular disease medicament | 广州白云山中一药业有限公司 | 2019-10-22 | — | — | CN | disclosed |
| EP-3289106-A1 | DIAGNOSTIC METHODS | Griffith University (AU) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176726-A1 | DIAGNOSTIC METHODS | GRIFFITH UNIVERSITY (AU) | 2016-11-10 | — | — | WO | disclosed |
| US-20090220968-A1 | Methods and Apparatus for Near Field Irradiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1996320-A2 | METHODS AND APPARATUS FOR NEAR FIELD IRRADIATION | The President and Fellows of Harvard College (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007106402-A2 | METHODS AND APPARATUS FOR NEAR FIELD IRRADIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-09-20 | — | — | WO | disclosed |