Hydrochloric Acid

Hydrochloric Acid

SCHEMBL4474844

Cl.NC(=S)NCc1ccccc1

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 3/20 0.63
CA2 known ✓ P00918 2/20 0.61
MAOA known ✓ P21397 1/20 0.55
MAOB known ✓ P27338 1/20 0.55
GRIN2D known ✓ O15399 2/20 0.53
GRIN3B known ✓ O60391 2/20 0.53
GRIN1 known ✓ Q05586 2/20 0.53
GRIN2A known ✓ Q12879 2/20 0.53
GRIN2B known ✓ Q13224 2/20 0.53
GRIN2C known ✓ Q14957 2/20 0.53
GRIN3A known ✓ Q8TCU5 2/20 0.53
SIGMAR1 known ✓ Q99720 2/20 0.53
ALOX12 P18054 4/20 0.65
ALDH1A1 P00352 2/20 0.65
HPGD P15428 2/20 0.65
MAPT P10636 3/20 0.63
MEN1 O00255 1/20 0.63
POLB P06746 1/20 0.63
KMT2A Q03164 1/20 0.63
CA12 O43570 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL133802 0.98 ALOX12 (0.68) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL2789014 0.96 ALOX12 (0.65) ALOX12ALDH1A1HPGDGAAMAPT
Bromide SCHEMBL16927550 0.96 ALOX12 (0.65) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3426065 0.86 KMT2A (0.57) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3077491 0.83 ALOX12 (0.65) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL1056093 0.83 ALOX12 (0.65) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3059505 0.82 ALDH1A1 (0.70) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3421753 0.81 AOC3 (0.62) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3427560 0.81 GAA (0.60) ALOX12ALDH1A1HPGDGAAMAPT
SCHEMBL3425867 0.81 BCHE (0.63) GAAMAPTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109181216-A A kind of stretch-proof plastic film 宁夏中诚塑胶有限公司 2019-01-11 CN claimed
CN-108529732-A A method of based on ionic liquid high-efficient purification iron protein waste water 河南师范大学 2018-09-14 CN claimed
CN-106917321-A A kind of mechanics ecological board and mechanics ecology board manufacturing method 西京学院 2017-07-04 CN claimed
CN-106867152-A A kind of sports place track material 景德镇陶瓷大学 2017-06-20 CN claimed
CN-106785081-A A kind of battery liquid and its battery 叶晓东 2017-05-31 CN claimed
CN-106674943-A Method for producing disposable tableware through polylactic acid 平凉市佳禾农产品加工有限责任公司 2017-05-17 CN claimed
CN-106384847-A Storage battery electrolyte and preparation method and storage battery thereof 叶晓东 2017-02-08 CN claimed
CN-1216181-C Chemical replacement silver plating additive, method for making same and use thereof TAIYUAN NORMAL COLLEGE (CN) 2005-08-24 CN claimed
CN-1544695-A Chemical replacement silver plating additive, method for making same and use thereof 太原师范学院 2004-11-10 CN claimed
CN-109181216-A A kind of stretch-proof plastic film 宁夏中诚塑胶有限公司 2019-01-11 CN disclosed
CN-109181216-A A kind of stretch-proof plastic film 宁夏中诚塑胶有限公司 2019-01-11 CN disclosed
CN-108529732-A A method of based on ionic liquid high-efficient purification iron protein waste water 河南师范大学 2018-09-14 CN disclosed
CN-107841031-A A kind of slow release agricultural plastic ground membrane and preparation method for prevention and control bacterial wilt 成都新柯力化工科技有限公司 2018-03-27 CN disclosed
CN-106917321-A A kind of mechanics ecological board and mechanics ecology board manufacturing method 西京学院 2017-07-04 CN disclosed
WO-2006071762-A2 PYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-07-06 WO disclosed
US-20060142576-A1 Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods BRISTOL-MYERS SQUIBB COMPANY 2006-06-29 US disclosed
CN-1216181-C Chemical replacement silver plating additive, method for making same and use thereof TAIYUAN NORMAL COLLEGE (CN) 2005-08-24 CN disclosed
CN-1216181-C Chemical replacement silver plating additive, method for making same and use thereof TAIYUAN NORMAL COLLEGE (CN) 2005-08-24 CN disclosed
WO-2005051380-A1 SUBSTITUTED UREA-OCTAHYDROINDOLS AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R) BIOVITRUM AB (SE) 2005-06-09 WO disclosed
CN-1544695-A Chemical replacement silver plating additive, method for making same and use thereof 太原师范学院 2004-11-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060142576-A1 Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods DPP4, DPP9, DPP3 GAA 207/4885CA2 3867/4885MAOA 2279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.