Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Netropsin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 2/20 | 0.56 |
| ▸ | ESR1 known ✓ | P03372 | 13/20 | 0.54 |
| ▸ | ESR2 known ✓ | Q92731 | 13/20 | 0.54 |
| ▸ | HDAC1 known ✓ | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 known ✓ | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.37 |
| ▸ | ERBB2 known ✓ | P04626 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HRAS | P01112 | 14/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Netropsin SCHEMBL951644 | 0.88 | TOP1 (0.71) | TOP1KDM4EPOLBMAPTHIF1A | |
| Netropsin SCHEMBL10408939 | 0.87 | TOP1 (0.72) | TOP1KDM4EPOLBMAPTHIF1A | |
| Netropsin SCHEMBL4953090 | 0.87 | TOP1 (0.72) | TOP1KDM4EPOLBMAPTHIF1A | |
| Netropsin SCHEMBL197747 | 0.86 | TOP1 (0.74) | TOP1KDM4EPOLBMAPTHIF1A | |
| SCHEMBL14267762 | 0.86 | TOP1 (0.74) | TOP1KDM4EPOLBMAPTHIF1A | |
| SCHEMBL12348338 | 0.84 | TOP1 (0.70) | TOP1KDM4EPOLBMAPTHIF1A | |
| Netropsin SCHEMBL4284668 | 0.81 | TOP1 (0.60) | TOP1KDM4EPOLBMAPTHIF1A | |
| SCHEMBL12348157 | 0.80 | TOP1 (0.65) | TOP1KDM4EPOLBMAPTHIF1A | |
| SCHEMBL19288091 | 0.78 | TOP1 (0.62) | TOP1KDM4EPOLBMAPTHIF1A | |
| Hydrochloric Acid SCHEMBL10424238 | 0.76 | TOP1 (0.70) | TOP1KDM4EPOLBMAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962243-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-02-24 | — | — | US | disclosed |
| US-8927243-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-01-06 | — | — | US | disclosed |
| US-8916698-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-12-23 | — | — | US | disclosed |
| US-8815502-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-08-26 | — | — | US | disclosed |
| US-8785176-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-07-22 | — | — | US | disclosed |
| US-8759479-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-06-24 | — | — | US | disclosed |
| US-8735090-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140142047-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-05-22 | — | — | US | disclosed |
| US-8592200-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-11-26 | — | — | US | disclosed |
| US-8574866-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-11-05 | — | — | US | disclosed |
| US-8465966-B2 | Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-06-18 | — | — | US | disclosed |
| US-20130130271-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130130302-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130130234-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130122509-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130115687-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130109885-A1 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-05-02 | — | — | US | disclosed |
| US-20120164714-A1 | Post Protein Hydrolysis Removal of a Potent Ribonuclease Inhibitor and the Enzymatic Capture of DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-06-28 | — | — | US | disclosed |
| US-7416843-B2 | Removing aurintricarboxylic acid (ATA), a reverse transcriptase inhibitor, from a blood sample containing ATA and a chaotropic salt for nucleic acid extraction by using urea and diethylenetriaminepentaacetate; high speed analysis by aggregationg fibrin to confine pathogens to extract pathogen DNA | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-08-26 | — | — | US | disclosed |
| US-20050277130-A1 | Removing aurintricarboxylic acid (ATA), a reverse transcriptase inhibitor, from a blood sample containing ATA and a chaotropic salt for nucleic acid extraction by using urea at a pH of about 8.0; high speed analysis by creating a fibrin aggregate to confine pathogens to facilitate pathogen DNA extraction | UNIVERSITY OF SOUTH FLORIDA | 2005-12-15 | — | — | US | disclosed |