Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Putrescine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Putrescine SCHEMBL7870217 | 0.94 | NFKB1 (0.88) | — | |
| Putrescine SCHEMBL313163 | 0.94 | — | — | |
| Putrescine SCHEMBL29458 | 0.94 | — | — | |
| Putrescine SCHEMBL4336637 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL344248 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL9460262 | 0.89 | DNM1 (0.89) | — | |
| Hydrochloric Acid SCHEMBL9129810 | 0.89 | DNM1 (0.89) | — | |
| SCHEMBL21074218 | 0.89 | — | — | |
| SCHEMBL3274965 | 0.89 | DNM1 (0.89) | — | |
| Hydrochloric Acid SCHEMBL284928 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9943545-B2 | Stem cell culture media and methods of enhancing cell survival | FATE THERAPEUTICS, INC. (US) | 2018-04-17 | — | — | US | claimed |
| CN-100362098-C | Non-serum culture medium for multiple animal cell large-scale culture | HUADONG SCIENCE & ENGINEERING (CN) | 2008-01-16 | — | — | CN | claimed |
| CN-1778903-A | High-density continous pouring culture of animal cell | HUADONG SCIENCE & ENGINEERING (CN) | 2006-05-31 | — | — | CN | claimed |
| CN-1778902-A | Non-serum culture medium for multiple animal cell large-scale culture | HUADONG SCIENCE & ENGINEERING (CN) | 2006-05-31 | — | — | CN | claimed |
| CN-1772883-A | Animal cell feeding culture process | EAST CHINA TECHNOLOGY UNIV (CN) | 2006-05-17 | — | — | CN | claimed |
| US-11135244-B2 | Stem cell culture media and methods of enhancing cell survival | FATE THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20180193381-A1 | STEM CELL CULTURE MEDIA AND METHODS OF ENHANCING CELL SURVIVAL | FATE THERAPEUTICS, INC. | 2018-07-12 | — | — | US | disclosed |
| US-9943545-B2 | Stem cell culture media and methods of enhancing cell survival | FATE THERAPEUTICS, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20150044176-A1 | STEM CELL CULTURE MEDIA AND METHODS OF ENHANCING CELL SURVIVIAL | FATE THERAPEUTICS, INC. (US) | 2015-02-12 | — | — | US | disclosed |
| US-20130333058-A1 | Pluripotent Cells From Rat and Other Species | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2013-12-12 | — | — | US | disclosed |
| US-8431395-B2 | Transgenic rodent for identifying modulators of pluripotency-associated gene products | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2013-04-30 | — | — | US | disclosed |
| US-20120207744-A1 | REPROGRAMMING COMPOSITIONS AND METHODS OF USING THE SAME | FATE THERAPEUTICS, INC. | 2012-08-16 | — | — | US | disclosed |
| US-20080066197-A1 | PLURIPOTENT CELLS FROM RAT AND OTHER SPECIES | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2008-03-13 | — | — | US | disclosed |
| CN-100362098-C | Non-serum culture medium for multiple animal cell large-scale culture | HUADONG SCIENCE & ENGINEERING (CN) | 2008-01-16 | — | — | CN | disclosed |
| CN-1778902-A | Non-serum culture medium for multiple animal cell large-scale culture | HUADONG SCIENCE & ENGINEERING (CN) | 2006-05-31 | — | — | CN | disclosed |
| CN-1778903-A | High-density continous pouring culture of animal cell | HUADONG SCIENCE & ENGINEERING (CN) | 2006-05-31 | — | — | CN | disclosed |
| CN-1772883-A | Animal cell feeding culture process | EAST CHINA TECHNOLOGY UNIV (CN) | 2006-05-17 | — | — | CN | disclosed |
| CN-1703422-A | Meth1 and meth2 polynucleotides and polypeptides | HUMAN GENOME SCIENCES INC (US) | 2005-11-30 | — | — | CN | disclosed |
| US-5837543-A | SUSPENSION OF CULTURE SYSTEM OF HUMAN TUBAL EPITHELIAL CELLS, DETACHING CELLS, SUSPENSION OF CELLS IN ANTIBIOTICS, ANTIFUNGAL CELLS | UAB RESEARCH FOUNDATION (US) | 1998-11-17 | — | — | US | disclosed |