Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.60 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.60 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797544 | 0.95 | — | — | |
| SCHEMBL6100699 | 0.95 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL2670598 | 0.95 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL28526434 | 0.95 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL4467850 | 0.84 | — | — | |
| Piperazine SCHEMBL20258219 | 0.84 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Hydrochloric Acid SCHEMBL4769861 | 0.84 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL282455 | 0.84 | — | — | |
| Piperazine SCHEMBL6598522 | 0.84 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Hydrochloric Acid SCHEMBL11801121 | 0.84 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160466-B2 | Uses of cucurbituril devices | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY FOUNDATION (KR) | 2007-01-09 | — | — | US | disclosed |
| US-20040039195-A1 | Cucurbituril derivatives, their preparation method and uses | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (KR) | 2004-02-26 | — | — | US | disclosed |
| EP-1094065-B1 | Preparation methods of cucurbituril derivatives | UNIV POHANG (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6639069-B2 | Pollution control | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (KR) | 2003-10-28 | — | — | US | disclosed |
| US-20020133003-A1 | Method of preparing and uses of cucurbituril devices | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (KR) | 2002-09-19 | — | — | US | disclosed |
| US-6365734-B1 | FRACTIONATION OR DISTILLATION OF COMPOUNDS FOR PESTICIDES | POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY FOUNDATION (KR) | 2002-04-02 | — | — | US | disclosed |
| EP-1094065-A2 | Cucurbituril derivatives, their preparation methods and uses | Pohang University of Science and Technology Foundation (KR) | 2001-04-25 | — | — | EP | disclosed |
| US-5869651-A | Hydrazide derivatives of polyamides and their medical use as chelating agents | NYCOMED SALUTAR (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0594734-B1 | HYDROXAMATE AND HYDRAZIDE DERIVATIVES OF POLYAMINES AND THEIR MEDICAL USE AS CHELATING AGENTS | NYCOMED SALUTAR INC (US) | 1998-06-24 | — | — | EP | disclosed |
| EP-0594734-A1 | HYDROXAMATE AND HYDRAZIDE DERIVATIVES OF POLYAMINES AND THEIR MEDICAL USE AS CHELATING AGENTS | NYCOMED SALUTAR, INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| WO-1993002045-A1 | HYDROXAMATE AND HYDRAZIDE DERIVATIVES OF POLYAMINES AND THEIR MEDICAL USE AS CHELATING AGENTS | NYCOMED SALUTAR, INC. (US) | 1993-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020133003-A1 | Method of preparing and uses of cucurbituril devices | H1-0, SIGMAR1, CBR3 | PDE4A 4844/4885KDR 2819/4885GAA 3075/4885 |
| US-20040039195-A1 | Cucurbituril derivatives, their preparation method and uses | CBR3, CBR1, H1-0 | PDE4A 4842/4885KDR 2955/4885GAA 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.