Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 known ✓ | P51681 | 3/20 | 0.88 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.70 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.59 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | CCR1 | P32246 | 3/20 | 0.88 |
| ▸ | CCR8 | P51685 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | POLB | P06746 | 1/20 | 0.88 |
| ▸ | METAP1 | P53582 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 1/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.88 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.88 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.88 |
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | TP53 | P04637 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL5251632 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL646317 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL2245805 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL7619601 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8214175 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5555235 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6517724 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL608684 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6496504 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6304360 | 0.97 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118048784-A | Flame-retardant functional layer on surface of fabric, preparation method of flame-retardant functional layer and flame-retardant fabric | 中国石油化工股份有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-116283765-A | Chlorotrifluoromethylation method of inactive olefin | 苏州大学 | 2023-06-23 | — | — | CN | claimed |
| CN-110467527-B | Method for preparing trans-D-chrysanthemic acid | 中国科学院大连化学物理研究所 | 2022-05-31 | — | — | CN | claimed |
| CN-118048784-A | Flame-retardant functional layer on surface of fabric, preparation method of flame-retardant functional layer and flame-retardant fabric | 中国石油化工股份有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-117836044-A | Defoaming agent, lubricating oil composition containing defoaming agent, and machine using lubricating oil composition | DIC株式会社 | 2024-04-05 | — | — | CN | disclosed |
| CN-111961088-B | Method for preparing cis-bis (2, 2' -bipyridine) ruthenium dichloride dihydrate | 昆明贵研新材料科技有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-116710542-A | Defoaming agent, lubricating oil composition containing defoaming agent, and machine using lubricating oil composition | DIC株式会社 | 2023-09-05 | — | — | CN | disclosed |
| CN-116615484-A | Compounds, leveling agents, coating compositions, resist compositions and articles | DIC株式会社 | 2023-08-18 | — | — | CN | disclosed |
| CN-116507655-A | Polymer containing silicone chain and coating composition containing the same | DIC株式会社 | 2023-07-28 | — | — | CN | disclosed |
| CN-116283765-A | Chlorotrifluoromethylation method of inactive olefin | 苏州大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-116034143-A | Polymer, coating composition, resist composition and article | DIC株式会社 | 2023-04-28 | — | — | CN | disclosed |
| CN-110467527-B | Method for preparing trans-D-chrysanthemic acid | 中国科学院大连化学物理研究所 | 2022-05-31 | — | — | CN | disclosed |
| CN-110132946-B | Aptamer sensor and preparation method and application thereof | 安徽师范大学 | 2021-09-28 | — | — | CN | disclosed |
| CN-109651621-B | Zirconium-based metal organic framework composite material and preparation method and application thereof | 安徽师范大学 | 2021-05-14 | — | — | CN | disclosed |
| CN-109651621-B | Zirconium-based metal organic framework composite material and preparation method and application thereof | 安徽师范大学 | 2021-05-14 | — | — | CN | disclosed |
| CN-111961088-A | Method for preparing cis-bis (2, 2' -bipyridine) ruthenium dichloride dihydrate | 昆明贵研新材料科技有限公司 | 2020-11-20 | — | — | CN | disclosed |
| EP-1625161-A4 | A SYNTHETIC BIOELASTOMER | COMMW SCIENT IND RES ORG (AU) | 2006-07-12 | — | — | EP | disclosed |
| EP-1625161-A1 | A SYNTHETIC BIOELASTOMER | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2006-02-15 | — | — | EP | disclosed |
| US-20050106652-A1 | Detecting coliform bacteria in food liquids and/or homogenates; immunoassay | BIOVERIS CORPORATION | 2005-05-19 | — | — | US | disclosed |
| WO-2004104043-A1 | A SYNTHETIC BIOELASTOMER | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2004-12-02 | — | — | WO | disclosed |