Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 known ✓ | P51681 | 3/20 | 0.82 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.67 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.56 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | CCR1 | P32246 | 3/20 | 0.82 |
| ▸ | CCR8 | P51685 | 3/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | METAP1 | P53582 | 1/20 | 0.82 |
| ▸ | BLM | P54132 | 1/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.82 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.82 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.82 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL608684 | 1.00 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6304360 | 1.00 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6517724 | 1.00 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5555235 | 1.00 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8214175 | 1.00 | KDM4E (0.82) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6037873 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL4337218 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5663541 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8765640 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL7120881 | 0.97 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9118688-A | — | — | None | — | — | JP | disclosed |
| US-6916606-B2 | Electrochemiluminescent assays | BIOVERIS CORPORATION (US) | 2005-07-12 | — | — | US | disclosed |
| US-20050106652-A1 | Detecting coliform bacteria in food liquids and/or homogenates; immunoassay | BIOVERIS CORPORATION | 2005-05-19 | — | — | US | disclosed |
| EP-0658564-B1 | Electroluminescent compounds and intermediates in their synthesis | IGEN INT INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6316607-B1 | AS LABLES IN DETECTING AND QUANTIFYING CHEMICAL, BIOCHEMICAL, AND BIOLOGICAL SUBSTANCES, DRUGS, METABOLITES, MICROORGANISMS | IGEN INTERNATIONAL, INC. | 2001-11-13 | — | — | US | disclosed |
| WO-1997032886-A1 | ECL LABELS HAVING IMPROVED NSB PROPERTIES | IGEN INTERNATIONAL, INC. (US) | 1997-09-12 | — | — | WO | disclosed |
| JP-H09118688-A | ELECTROCHEMICAL LUMINESCENCE ASSAY | IGEN INC | 1997-05-06 | — | — | JP | disclosed |
| EP-0265519-B1 | ELECTROCHEMILUMINESCENT ASSAYS | IGEN INC (US) | 1995-09-13 | — | — | EP | disclosed |
| EP-0658564-A1 | Electroluminescent compounds and intermediates in their synthesis | IGEN, INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0647849-A2 | Detecting the presence of analytes in a sample | IGEN, INC. (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0265519-A4 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1990-05-14 | — | — | EP | disclosed |
| EP-0265519-A1 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1988-05-04 | — | — | EP | disclosed |
| WO-1987006706-A1 | ELECTROCHEMILUMINESCENT ASSAYS | IGEN, INC. (US) | 1987-11-05 | — | — | WO | disclosed |