Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.40 |
| ▸ | NPY4R | P50391 | 16/20 | 0.49 |
| ▸ | NPY1R | P25929 | 10/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.49 |
| ▸ | NPY2R | P49146 | 6/20 | 0.49 |
| ▸ | Q9HBH1 | 1/20 | 0.45 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1259758 | 1.00 | NPY4R (0.49) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL1694104 | 0.99 | NPY4R (0.49) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL1694377 | 0.99 | NPY4R (0.49) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL4799804 | 0.99 | NPY4R (0.49) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL8089028 | 0.91 | PDF (0.47) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL11374268 | 0.87 | PDF (0.49) | NPY4RNPY1RNPY5RNPY2RPDF | |
| SCHEMBL8723156 | 0.87 | PDF (0.52) | NPY4RNPY1RNPY5RNPY2RPDF | |
| Hydrochloric Acid SCHEMBL3481900 | 0.87 | PDF (0.60) | PDFSSTR3MEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8853773 | 0.87 | PDF (0.60) | PDFSSTR3MEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3482618 | 0.87 | PDF (0.60) | PDFSSTR3MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006217-A1 | Comprises coagulation factor VIIa/VII receptor for treatment and prevention of thrombosis, septic shock and adult respiratory distress syndrome (ARDS); anticoagulants; thrombolytic agents | GENENTECH, INC. (US) | 2004-01-08 | — | — | US | disclosed |
| US-6596847-B2 | Tissue protein for use in ther treatment of stroke, thrombosis, septic shock, adult respiratory distress syndrome, hypotension and cancer | GENENTECH, INC. | 2003-07-22 | — | — | US | disclosed |
| US-20020142373-A1 | TISSUE FACTOR PROTEIN VARIANTS | GENENTECH, INC. | 2002-10-03 | — | — | US | disclosed |
| EP-1105475-A1 | TISSUE FACTOR PROTEIN VARIANTS WITH INCREASED AFFINITY FOR COAGULATION FACTOR FVII/FVIIA | Genentech, Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000004148-A1 | TISSUE FACTOR PROTEIN VARIANTS WITH INCREASED AFFINITY FOR COAGULATION FACTOR FVII/FVIIA | GENENTECH, INC. (US) | 2000-01-27 | — | — | WO | disclosed |
| US-5667979-A | PROTEASE | LABORATORIOS LETI S.A. (ES) | 1997-09-16 | — | — | US | disclosed |
| EP-0377229-B1 | Use of specific properties of allergens from animal sources and methods for their isolation | LETI LAB (ES) | 1996-06-26 | — | — | EP | disclosed |
| EP-0377229-A1 | Use of specific properties of allergens from animal sources and methods for their isolation | C.B.F. LETI, S.A. (ES) | 1990-07-11 | — | — | EP | disclosed |