Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Isobutyramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isobutyramide SCHEMBL28256794 | 1.00 | LMNA (0.43) | — | |
| Isobutyramide SCHEMBL7090821 | 1.00 | — | — | |
| Isobutyramide SCHEMBL2402176 | 1.00 | — | — | |
| Isobutyramide SCHEMBL27318890 | 0.96 | — | — | |
| Isobutyramide SCHEMBL27782244 | 0.96 | — | — | |
| Isobutyramide SCHEMBL27733619 | 0.96 | — | — | |
| Isobutyramide SCHEMBL2829019 | 0.96 | — | — | |
| Isobutyramide SCHEMBL11109750 | 0.96 | LMNA (0.46) | — | |
| Isobutyramide SCHEMBL3323 | 0.96 | — | — | |
| Isobutyramide SCHEMBL5830040 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577535-B2 | Substantially solid acidizing composition for treatment of subterranean formations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2020-03-03 | — | — | US | claimed |
| CN-104507933-B | Amido quinazoline and Pyridopyrimidine derivatives | 霍夫曼-拉罗奇有限公司 | 2017-10-31 | — | — | CN | claimed |
| US-20160272879-A1 | SUBSTANTIALLY SOLID ACIDIZING COMPOSITION FOR TREATMENT OF SUBTERRANEAN FORMATIONS | HALLIBURTON ENERGY SERVICES, INC. | 2016-09-22 | — | — | US | claimed |
| WO-2015126397-A1 | SUBSTANTIALLY SOLID ACIDIZING COMPOSITION FOR TREATMENT OF SUBTERRANEAN FORMATIONS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2015-08-27 | — | — | WO | claimed |
| US-8852634-B2 | Dosage formulation | HOFFMANN-LA ROCHE INC. (US) | 2014-10-07 | — | — | US | claimed |
| US-20130189362-A1 | NOVEL DOSAGE FORMULATION | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | claimed |
| CN-101370799-B | Cis-4, 5-diaryl-2-heterocycle-imidazolines as MDM2 inhibitors | HOFFMANN LA ROCHE | 2012-09-05 | — | — | CN | claimed |
| CN-1953965-B | Novel cis-imidazolines | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | claimed |
| CN-101880354-B | High molecular emulsion polymer and preparation method thereof | PUYANG CITY CHENGXIN DRILLING PRODUCTION AGENTS CO LTD | 2012-05-30 | — | — | CN | claimed |
| CN-101249996-B | Organic high polymer coagulant preparation method | UNIV SICHUAN NORMAL | 2011-07-20 | — | — | CN | claimed |
| CN-100402564-C | Water soluble organic amphoteric high molecule copolymer and its preparation method | UNIV SICHUAN (CN) | 2008-07-16 | — | — | CN | claimed |
| CN-101155784-A | Cis-2,4,5-triaryl-imidazolines and their use as anti-cancer medicaments | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | claimed |
| CN-100368452-C | Water-soluble organic amphiprotic polymeric flocculant and preparation method | UNIV SICHUAN NORMAL (CN) | 2008-02-13 | — | — | CN | claimed |
| US-7253320-B2 | Process for preparing polymorphic form II of sertraline hydrochloride | SANDOZ AG (CH) | 2007-08-07 | — | — | US | claimed |
| CN-1953965-A | Novel cis-imidazolines | HOFFMANN LA ROCHE (CH) | 2007-04-25 | — | — | CN | claimed |
| CN-1880353-A | Water-soluble organic amphiprotic polymeric flocculant and preparation method | UNIV SICHUAN NORMAL (CN) | 2006-12-20 | — | — | CN | claimed |
| CN-1869088-A | Water soluble organic amphoteric high molecule copolymer and its preparation method | UNIV SICHUAN (CN) | 2006-11-29 | — | — | CN | claimed |
| US-20060229472-A1 | Process for preparing polymorphic form II of sertraline hydrochloride | SANDOZ AG (CH) | 2006-10-12 | — | — | US | claimed |
| EP-1501858-A2 | FURTHER SYNTHESES OF CYPROTERONE ACETATE | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 2005-02-02 | — | — | EP | claimed |
| WO-2003092578-A2 | FURTHER SYNTHESES OF CYPROTERONE ACETATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2003-11-13 | — | — | WO | claimed |