Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.36 |
| ▸ | FDPS | P14324 | 9/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815035 | 0.98 | LMNA (0.44) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL2598044 | 0.98 | LMNA (0.44) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3154978 | 0.89 | HRH3 (0.45) | ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL22577656 | 0.89 | TSHR (0.42) | TSHRGGPS1FDPSEPHX1CES2 | |
| Hydrochloric Acid SCHEMBL31467545 | 0.89 | TSHR (0.42) | TSHRGGPS1FDPSEPHX1CES2 | |
| Hydrochloric Acid SCHEMBL27970377 | 0.89 | TSHR (0.42) | TSHRGGPS1FDPSEPHX1CES2 | |
| Hydrochloric Acid SCHEMBL31467543 | 0.89 | TSHR (0.42) | TSHRGGPS1FDPSEPHX1CES2 | |
| SCHEMBL2227498 | 0.87 | TSHR (0.44) | TSHRGGPS1FDPSEPHX1CES2 | |
| SCHEMBL5382076 | 0.87 | TSHR (0.44) | TSHRGGPS1FDPSEPHX1CES2 | |
| SCHEMBL8497514 | 0.83 | LMNA (0.40) | LMNAALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208268-B1 | NOVEL QUATERNARY COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | EVONIK GOLDSCHMIDT CORP (US) | 2013-07-10 | — | — | EP | disclosed |
| US-6794437-B2 | Clay/organic chemical compositions useful as additives to polymer, plastic and resin matrices to produce nanocomposites and nonocomposites containing such compositions | ELEMENTIS SPECIALTIES, INC. | 2004-09-21 | — | — | US | disclosed |
| US-20040087700-A1 | CLAY/ORGANIC CHEMICAL COMPOSITIONS USEFUL AS ADDITIVES TO POLYMER, PLASTIC AND RESIN MATRICES TO PRODUCE NANOCOMPOSITES AND NANOCOMPOSITES CONTAINING SUCH COMPOSITIONS | RHEOX, INC. | 2004-05-06 | — | — | US | disclosed |
| EP-0803283-B1 | Cationic compositions containing hydroxyester | GOLDSCHMIDT CHEMICAL CORP (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-1045891-A4 | NOVEL QUATERNARY AMMONIUM COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | GOLDSCHMIDT CHEMICAL CORP (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6458343-B1 | Quaternary compounds, compositions containing them, and uses thereof | GOLDSCHMIDT CHEMICAL CORPORATION | 2002-10-01 | — | — | US | disclosed |
| EP-1208268-A1 | NOVEL QUATERNARY COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | Goldschmidt Chemical Company (US) | 2002-05-29 | — | — | EP | disclosed |
| US-6380295-B1 | MIXTURE OF SMECTITE CLAY, QUATERNARY AMMONIUM COMPOUND AND POLYMER | RHEOX INC. | 2002-04-30 | — | — | US | disclosed |
| US-6376455-B1 | FABRIC SOFTENER, QUATERNARY FATTY ACID AMINO ALCOHOL ESTERS OF METHYLETHANOLISOPROPANOLAMINE (MEIPA) WITH FATTY ACIDS IN THE RATIO OF FROM 1:1.5 TO 1:2 WITH USE OF MONOFUNCTIONAL ALCOHOLS OR BIFUNCTIONAL ALCOHOLS. | GOLDSCHMIDT REWO GMBH & CO. KG (DE) | 2002-04-23 | — | — | US | disclosed |
| WO-2001085109-A1 | NOVEL QUATERNARY COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | GOLDSCHMIDT CHEMICAL COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |
| EP-0368376-A2 | Water-insoluble red colors for liquid fabric softeners | THE PROCTER & GAMBLE COMPANY (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4897208-A | CONTAINING SPECIFIC D AND C RED DYES | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0333255-A2 | Liquid fabric softener | THE PROCTER & GAMBLE COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4863620-A | RINSING BATHS | THE PROCTER & GAMBLE COMPANY (US) | 1989-09-05 | — | — | US | disclosed |
| US-4855072-A | Liquid fabric softener | THE PROCTER & GAMBLE COMPANY (US) | 1989-08-08 | — | — | US | disclosed |
| US-4844820-A | REDUCED STAINING | THE PROCTER & GAMBLE COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| US-4822499-A | WATER-SOLUBLE DYES STABLE IN ACIDIC CONDITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0304410-A2 | Liquid fabric softener | THE PROCTER & GAMBLE COMPANY (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4661269-A | REACTION PRODUCT OF HIGHER FATTY ACIDS WITH POLYAMINES AND CATIONIC NITROGEN SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0199382-A2 | Liquid fabric softener | THE PROCTER & GAMBLE COMPANY (US) | 1986-10-29 | — | — | EP | disclosed |