Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 4/20 | 0.38 |
| ▸ | HDAC1 known ✓ | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC2 known ✓ | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8900380 | 1.00 | CES1 (0.39) | CES1CES2HDAC3HDAC1HDAC2 | |
| SCHEMBL2151557 | 0.97 | CES1 (0.41) | CES1CES2HDAC3HDAC1HDAC2 | |
| SCHEMBL116654 | 0.97 | CES1 (0.41) | CES1CES2HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL10322255 | 0.83 | FNTA (0.42) | CES1CES2HDAC3HDAC1HDAC2 | |
| SCHEMBL10698087 | 0.83 | CES1 (0.46) | CES1CES2TSHRALDH1A1TDP1 | |
| SCHEMBL20163587 | 0.83 | CES1 (0.46) | CES1CES2TSHRALDH1A1TDP1 | |
| SCHEMBL1127675 | 0.82 | ALDH1A1 (0.31) | CES1CES2ALDH1A1 | |
| SCHEMBL3596261 | 0.80 | HDAC3 (0.43) | CES1CES2HDAC3HDAC1HDAC2 | |
| SCHEMBL1276172 | 0.80 | HDAC3 (0.43) | CES1CES2HDAC3HDAC1HDAC2 | |
| SCHEMBL3508068 | 0.79 | CES2 (0.50) | CES1CES2TSHRALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599741-B1 | Photographic support material comprising an antistatic layer and a heat-thickening barrier layer | EASTMAN KODAK CO (US) | 1999-03-10 | — | — | EP | claimed |
| EP-0213896-B1 | ADHESION PROMOTING POLYMERIC MATERIALS | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1992-01-22 | — | — | EP | claimed |
| EP-0213896-A2 | Adhesion promoting polymeric materials | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1987-03-11 | — | — | EP | claimed |
| US-11866588-B2 | Polymerizable near-IR dyes | PROFUSA, INC. (US) | 2024-01-09 | — | — | US | disclosed |
| EP-4111850-A1 | A COLOR-BASED HUMIDITY INDICATOR IN A PLANT CULTIVATION CONTAINER | Freshape SA (CH) | 2023-01-04 | — | — | EP | disclosed |
| US-20210026054-A1 | PHOTO-STABLE AND THERMALLY-STABLE DYE COMPOUNDS FOR SELECTIVE BLUE LIGHT FILTERED OPTIC | FRONTIER SCIENTIFIC INC. | 2021-01-28 | — | — | US | disclosed |
| US-20200140690-A1 | POLYMERIZABLE NEAR-IR DYES | PROFUSA, INC. (US) | 2020-05-07 | — | — | US | disclosed |
| EP-3558118-A1 | POLYMERIZABLE NEAR-IR DYES | Profusa, Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| US-20180259693-A1 | PHOTO-STABLE AND THERMALLY-STABLE DYE COMPOUNDS FOR SELECTIVE BLUE LIGHT FILTERED OPTIC | FRONTIER SCIENTIFIC, INC. (US) | 2018-09-13 | — | — | US | disclosed |
| WO-2018119204-A1 | POLYMERIZABLE NEAR-IR DYES | PROFUSA, INC. (US) | 2018-06-28 | — | — | WO | disclosed |
| US-20170235034-A1 | PHOTO-STABLE AND THERMALLY-STABLE DYE COMPOUNDS FOR SELECTIVE BLUE LIGHT FILTERED OPTIC | FRONTIER SCIENTIFIC, INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-9289395-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof | NANOPHARMACEUTICALS LLC (US) | 2016-03-22 | — | — | US | disclosed |
| US-6537730-B1 | Heat-sensitive hydrophilic polymer having ionic moieties and an infrared radiation sensitive dye having multiple sulfo groups | KODAK POLYCHROME GRAPHICS LLC | 2003-03-25 | — | — | US | disclosed |
| WO-2003010600-A2 | METHOD AND SYSTEM FOR DIRECT-TO-PRESS IMAGING | KODAK POLYCHROME GRAPHICS LLC (US) | 2003-02-06 | — | — | WO | disclosed |
| US-6159657-A | Thermal imaging composition and member containing sulfonated ir dye and methods of imaging and printing | EASTMAN KODAK COMPANY (US) | 2000-12-12 | — | — | US | disclosed |