Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.34 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.33 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29353415 | 0.98 | ALDH1A1 (0.38) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL56503 | 0.98 | ALDH1A1 (0.38) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL2249411 | 0.96 | ALDH1A1 (0.37) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL18096530 | 0.96 | ALDH1A1 (0.37) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL2642874 | 0.96 | ALDH1A1 (0.37) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| Hydrochloric Acid SCHEMBL15608549 | 0.94 | ALDH1A1 (0.35) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| Dimethylamine SCHEMBL25241553 | 0.92 | ALDH1A1 (0.34) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL15546288 | 0.92 | CYP2A6 (0.39) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL31379078 | 0.90 | CYP2A6 (0.38) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD | |
| SCHEMBL4428859 | 0.90 | PTGS2 (0.37) | ALDH1A1HSD17B10CYP2A6MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1688424-B1 | PHOSPHONIUM BORATE COMPOUND AND METHOD OF USING THE SAME | HOKKO CHEM IND CO (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-8604249-B2 | Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2013-12-10 | — | — | US | disclosed |
| US-8124809-B2 | Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20110237799-A1 | Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110166389-A1 | Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-7728176-B2 | Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-06-01 | — | — | US | disclosed |
| US-20090305877-A1 | Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| US-20070098616-A1 | Process for producing phosponium borate compound, novel phosphonium borate compound, and method of using the same | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-05-03 | — | — | US | disclosed |
| EP-1688424-A1 | PROCESS FOR PRODUCING PHOSPHONIUM BORATE COMPOUND, NOVEL PHOSPHONIUM BORATE COMPOUND, AND METHOD OF USING THE SAME | HOKKO CHEMICAL INDUSTRY CO. LTD. (JP) | 2006-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166389-A1 | Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same | CA4, EPB41, MAPK4 | PTGS2 3825/4885DPP4 2070/4885HDAC4 201/4885 |
| US-20110237799-A1 | Process for Producing Phosphonium Borate Compound, Novel Phosphonium Borate Compound, and Method of Using the Same | EPB41, CA4, RBBP4 | PTGS2 3914/4885DPP4 1911/4885HDAC4 171/4885 |
| US-20090305877-A1 | Process for producing phosphonium borate compound, novel phosphonium borate compound, and method of using the same | PHOSPHO1, BRI3BP, CA4 | PTGS2 4551/4885DPP4 3102/4885HDAC4 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.