Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 7/20 | 0.96 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 4/20 | 0.96 |
| ▸ | HTR3B known ✓ | O95264 | 4/20 | 0.96 |
| ▸ | HTR3A known ✓ | P46098 | 4/20 | 0.96 |
| ▸ | HTR3D known ✓ | Q70Z44 | 4/20 | 0.96 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 4/20 | 0.96 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.96 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.61 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.61 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.61 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.61 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.58 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.58 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.58 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.58 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.58 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.58 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL314621 | 1.00 | ADRB1 (0.96) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL219742 | 0.98 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL894618 | 0.98 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Formaldehyde SCHEMBL27861281 | 0.94 | ADRB1 (0.85) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7527162 | 0.92 | ADRB1 (0.88) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL29089117 | 0.90 | ADRB1 (0.85) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL658716 | 0.90 | ADRB1 (0.85) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Bicarbonate SCHEMBL11625611 | 0.88 | ADRB1 (0.81) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL588594 | 0.87 | ADRB1 (0.79) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Alcohol SCHEMBL11585083 | 0.87 | ADRB1 (0.79) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119768002-A | Perovskite solar cell and preparation method thereof | 中国华能集团清洁能源技术研究院有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-117658854-A | Preparation method of 2-nitro-4-trifluoromethyl benzonitrile | 江西巍华化学有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-218502362-U | High-sealing centrifugal machine for preparing 2-nitro-4-trifluoromethyl benzonitrile | 青岛和兴精细化学有限公司 | 2023-02-21 | — | — | CN | claimed |
| CN-114907232-A | Synthesis process of 2-nitro-4-trifluoromethyl benzonitrile | 青岛和兴精细化学有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-109438282-A | The preparation method of 2- nitro -4- trifluoromethylbenzonitrile | 大连奇凯医药科技有限公司 | 2019-03-08 | — | — | CN | claimed |
| CN-104098486-B | A kind of preparation method of 2-nitro-4-trifluoromethylbenzonitrile | ZHEJIANG UNIVERSITY (CN) | 2016-02-17 | — | — | CN | claimed |
| CN-105175282-A | Preparation method for 2-nitro-4-(trifluoromethyl)benzonitrile | QINGDAO UNION FINE CHEMICAL CO LTD | 2015-12-23 | — | — | CN | claimed |
| CN-104926691-A | Preparation method of 2-nitro-4-trifluoromethylbenzonitrile | JIANGSU AGROCHEM LAB CO LTD | 2015-09-23 | — | — | CN | claimed |
| EP-0758643-B1 | Process for the preparation of ortho-nitro-benzonitriles | CLARIANT GMBH (DE) | 2000-05-17 | — | — | EP | claimed |
| US-5705674-A | Process for preparing ortho-nitrobenzonitriles | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-06 | — | — | US | claimed |
| US-4868333-A | Production of 2-nitro-4-trifluoromethylbenzoic acid | ICI AMERICAS INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-12459899-B2 | Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient | DIGMBIO, Inc. (KR) | 2025-11-04 | — | — | US | disclosed |
| US-20250263426-A1 | PDE4B INHIBITOR AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2025-08-21 | — | — | US | disclosed |
| EP-4594294-A1 | DOPAMINE D3/D2 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2025-08-06 | — | — | EP | disclosed |
| EP-4570804-A1 | PDE4B INHIBITOR AND USE THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2025-06-18 | — | — | EP | disclosed |
| EP-0551527-A1 | PYRROLOAZEPINE DERIVATIVE | SUNTORY LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-4868333-A | Production of 2-nitro-4-trifluoromethylbenzoic acid | ICI AMERICAS INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868333-A | Production of 2-nitro-4-trifluoromethylbenzoic acid | ICI AMERICAS INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4307113-A | TREATMENT OF DIABETES | SANDOZ, INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-RE28939-E | MUSCLE RELAXANTS, ANALGESICS | SMITHKLINE CORPORATION (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459899-B2 | Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient | PARP1, PARP2, PARP11 | ADRB1 2178/4885HTR3E 1840/4885HTR3B 3146/4885 |
| US-20250263426-A1 | PDE4B INHIBITOR AND USE THEREOF | PDE4B, PDE4A, PDE3B | ADRB1 59/4885HTR3E 3795/4885HTR3B 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.