Hydrochloric Acid

Hydrochloric Acid

SCHEMBL716679

Cl.O=Nc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.59
SLC6A2 known ✓ P23975 1/20 0.59
PTGS2 known ✓ P35354 1/20 0.59
HTR2B known ✓ P41595 1/20 0.59
MAPK14 known ✓ Q16539 1/20 0.47
GAA known ✓ P10253 3/20 0.46
ALDH1A1 P00352 10/20 0.95
HSD17B10 Q99714 6/20 0.95
CYP3A4 P08684 4/20 0.95
TSHR P16473 3/20 0.95
TDP1 Q9NUW8 3/20 0.95
HTT P42858 2/20 0.95
ALOX12 P18054 6/20 0.59
L3MBTL1 Q9Y468 6/20 0.59
MAPK1 P28482 3/20 0.59
ALOX15 P16050 2/20 0.59
KMT2A Q03164 3/20 0.49
CASP3 P42574 2/20 0.49
SENP7 Q9BQF6 2/20 0.49
S100B P04271 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL655572 0.98 ALDH1A1 (1.00) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL10866233 0.95 ALDH1A1 (0.95) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL29947657 0.84 ALDH1A1 (0.76) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL5953329 0.83 ALDH1A1 (0.72) ALDH1A1HSD17B10CYP3A4TSHRTDP1
Diphenylamine SCHEMBL6528581 0.81 ALDH1A1 (0.69) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL8966246 0.78 ALDH1A1 (0.67) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL9225008 0.77 ALDH1A1 (0.65) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL9221118 0.77 ALDH1A1 (0.65) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL9222756 0.77 ALDH1A1 (0.65) ALDH1A1HSD17B10CYP3A4TSHRTDP1
SCHEMBL9220119 0.77 ALDH1A1 (0.65) ALDH1A1HSD17B10CYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0107336-B1 PREPARATION OF P-NITROSODIPHENYLAMINE UNIROYAL, INC. (US) 1987-07-15 EP claimed
EP-0107335-B1 PROCESS FOR THE PREPARATION OF P-NITROSODIPHENYLAMINE UNIROYAL, INC. (US) 1986-12-03 EP claimed
US-4518803-A FROM DIPHENYLAMINE ALKYL NITRITE AND HYDROCHLORIC ACID IN ALIPHATIC ALCOHOL UNIROYAL, INC. (US) 1985-05-21 US claimed
US-4479008-A Preparation of p-nitrosodiphenylamine UNIROYAL, INC. (US) 1984-10-23 US claimed
EP-0107335-A1 Process for the preparation of p-nitrosodiphenylamine UNIROYAL, INC. (US) 1984-05-02 EP claimed
EP-0107336-A1 Preparation of P-nitrosodiphenylamine UNIROYAL, INC. (US) 1984-05-02 EP claimed
EP-0026316-B1 PROCESS FOR THE PREPARATION OF 4-NITROSO-DIPHENYL AMINE BAYER AG (DE) 1982-05-26 EP claimed
US-4324913-A REARRANGEMENT OF N-NITROSODIPHENYLAMINE, HYDROCHLORIC ACID, O-DICHLOROBENZENE SOLVENT BAYER AKTIENGESELLSCHAFT (DE) 1982-04-13 US claimed
EP-0026316-A1 Process for the preparation of 4-nitroso-diphenyl amine BAYER AG (DE) 1981-04-08 EP claimed
US-4102926-A Method for producing 4-nitrosodiphenylamine USVYATSOV ALDAN ALEXANDROVICH 1978-07-25 US claimed
US-4034042-A Process for the production of 4-nitroso-diphenylamine BAYER AKTIENGESELLSCHAFT (DT) 1977-07-05 US claimed
JP-54003020-A None JP disclosed
JP-54003019-A None JP disclosed
JP-6329601-A None JP disclosed
JP-6306022-A None JP disclosed
US-4102926-A Method for producing 4-nitrosodiphenylamine USVYATSOV ALDAN ALEXANDROVICH 1978-07-25 US disclosed
US-4102926-A Method for producing 4-nitrosodiphenylamine USVYATSOV ALDAN ALEXANDROVICH 1978-07-25 US disclosed
US-4034042-A Process for the production of 4-nitroso-diphenylamine BAYER AKTIENGESELLSCHAFT (DT) 1977-07-05 US disclosed
US-3978131-A PROCESS FOR PREPARING 4-AMINO-DIPHENYLAMINE BAYER AKTIENGESELLSCHAFT (DT) 1976-08-31 US disclosed
US-3748362-A PRODUCTION OF 4-NITROSODIPHENYLAMINE AMERICAN CYANAMID CO 1973-07-24 US disclosed