SCHEMBL718718

SCHEMBL718718

COc1cc(-c2oc3cccc(OC)c3c(=O)c2OC)c(OC)c(OC)c1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 1/20 0.54
TSHR P16473 1/20 0.54
CYP2C19 P33261 1/20 0.54
HSD17B10 Q99714 1/20 0.54
ABCG2 Q9UNQ0 7/20 0.53
ADORA3 P0DMS8 4/20 0.53
ABCB1 P08183 4/20 0.53
SLC22A2 O15244 1/20 0.51
SLC22A1 O15245 1/20 0.51
MAOA P21397 2/20 0.50
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MAPK1 P28482 1/20 0.49
ABCC1 P33527 1/20 0.49
KMT2A Q03164 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
TUBB4A P04350 2/20 0.47
TUBB P07437 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1764660 0.88 KDM4E (0.56) KDM4ECYP3A4CYP2C9TSHRCYP2C19
SCHEMBL775093 0.85 MGAM (0.53) KDM4ECYP3A4CYP2C9TSHRCYP2C19
SCHEMBL16894621 0.83 ABCG2 (0.73) KDM4ECYP3A4ABCG2ADORA3ABCB1
SCHEMBL571690 0.82 MAOA (0.48) KDM4ECYP3A4CYP2C9TSHRCYP2C19
SCHEMBL380907 0.80 ADORA3 (0.73) KDM4ECYP3A4CYP2C9TSHRCYP2C19
SCHEMBL16894634 0.78 ABCB1 (0.51) KDM4ECYP3A4ABCG2ADORA3ABCB1
SCHEMBL25065758 0.76 MEN1 (0.70) KDM4EHSD17B10ABCG2ABCB1MEN1
SCHEMBL17237780 0.75 MAOA (0.59) KDM4ECYP3A4CYP2C9TSHRCYP2C19
SCHEMBL31182979 0.75 ABCG2 (0.55) KDM4ECYP3A4CYP2C9HSD17B10ABCG2
SCHEMBL774317 0.74 ADORA3 (0.72) KDM4ECYP3A4CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118091005-A Method for detecting multiple components in deer astragalus kidney-tonifying particles 上海市第七人民医院(上海中医药大学附属第七人民医院) 2024-05-28 CN claimed
CN-109374762-B Method for identifying citrus reticulata blanco and citrus reticulata blanco varieties based on metabonomics 广州中医药大学第一附属医院 2021-10-08 CN claimed
US-20100178390-A1 Micronutrient-Simulated Beverages THE COCA-COLA COMPANY (US) 2010-07-15 US claimed
WO-2010080866-A2 MICRONUTRIENT-SIMULATING BEVERAGES THE COCA-COLA COMPANY (US) 2010-07-15 WO claimed
US-20260115294-A1 DERIVATIVES OF 5-HYDROXYLATED POLYMETHOXYFLAVONES WITH ENHANCED BIOAVAILABILITY FOR ORAL DELIVERY AND COMPOSITIONS THEREOF DEEPSENSE BIOTECHNOLOGIES INC (US) 2026-04-30 US disclosed
US-20260118258-A1 VALIDATION OF NATURAL MATRICES FOR THERAPEUTIC USE BIOS THERAPY PHYSIOLOGICAL SYSTEMS FOR HEALTH S P A (IT) 2026-04-30 US disclosed
US-12546707-B2 Validation of natural matrices for therapeutic use Bios-Therapy, PhysiologicalSystems for Health S.p.A. (IT) 2026-02-10 US disclosed
US-20250383340-A1 METHODS FOR DETERMINING WHEN A NATURAL THERAPEUTIC OR BENEFICIAL PRODUCT EXERTS ITS THERAPEUTIC OR BENEFICIAL EFFECT THROUGH A PHYSIOLOGICAL MODE OF ACTION BIOS-THERAPY, PHYSIOLOGICAL SYSTEMS FOR HEALTH S.P.A. (IT) 2025-12-18 US disclosed
US-20250383343-A1 METHODS FOR DETERMINING WHEN A NATURAL THERAPEUTIC OR BENEFICIAL PRODUCT EXERTS ITS THERAPEUTIC OR BENEFICIAL EFFECT THROUGH A PHYSIOLOGICAL MODE OF ACTION BIOS-THERAPY, PHYSIOLOGICAL SYSTEMS FOR HEALTH S.P.A. (IT) 2025-12-18 US disclosed
US-20250231101-A1 VALIDATION OF NATURAL MATRICES FOR THERAPEUTIC USE ON HUMANS, ANIMALS AND PLANTS ON BIO-PHYSICAL BASES AS AN ALTERNATIVE TO VALIDATION THROUGH CHEMICALLY DEFINABLE SUBSTANCES DERIVED FROM SAID MATRICES BY ISOLATION AND/OR SYNTHESIS PROCESSES AND ALSO AS AN ALTERNATIVE TO PRODUCTS COMPRISING NATURAL MATRICES VALIDATED ON THE BASIS OF THEIR TRADITIONAL USE BIOS-THERAPY, PHYSIOLOGICAL SYSTEMS FOR HEALTH S.P.A. (IT) 2025-07-17 US disclosed
CN-120009445-A Detection method and kit for ageing process 中国检验检疫科学研究院 2025-05-16 CN disclosed
EP-4493725-A1 METHODS FOR STRATIFICATION OF PARKINSON'S DISEASE PATIENTS, SYSTEMS AND USES THEREOF Université du Luxembourg (LU) 2025-01-22 EP disclosed
WO-2007024982-A2 METHODS FOR MANAGING ADIPOCYTE FAT ACCUMULATION WELLGEN, INC. (US) 2007-03-01 WO disclosed
US-20070042972-A1 Compositions and methods for optimizing exercise recovery RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2007-02-22 US disclosed
WO-2006127996-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2006-11-30 WO disclosed
US-6987125-B1 Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 2006-01-17 US disclosed
US-20050226828-A1 Method for whitening human skin NOF CORPORATION 2005-10-13 US disclosed
EP-1119353-A4 COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN KGK SYNERGIZE INC (CA) 2002-08-28 EP disclosed
EP-1119353-A1 COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN KGK Synergize Inc. (CA) 2001-08-01 EP disclosed
WO-2000019998-A1 COMPOSITIONS AND METHODS OF INHIBITING NEOPLASTIC DISEASES WITH COMPOUNDS RELATED TO LIMOCITRIN AND 5-DESMETHYL SINENSETIN KGK SYNERGIZE (CA) 2000-04-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042972-A1 Compositions and methods for optimizing exercise recovery GYS1, PYGM, PRDX5 KDM4E 121/4885CYP3A4 144/4885CYP2C9 93/4885
US-20050226828-A1 Method for whitening human skin CUTA, POLN, PLIN5 KDM4E 454/4885CYP3A4 2403/4885CYP2C9 1637/4885
US-12546707-B2 Validation of natural matrices for therapeutic use COL2A1, IL1B, COL1A1 KDM4E 2599/4885CYP3A4 2885/4885CYP2C9 2064/4885
US-20260115294-A1 DERIVATIVES OF 5-HYDROXYLATED POLYMETHOXYFLAVONES WITH ENHANCED BIOAVAILABILITY FOR ORAL DELIVERY AND COMPOSITIONS THEREOF PLIN3, PNLIP, FABP2 KDM4E 2460/4885CYP3A4 39/4885CYP2C9 178/4885
US-20260118258-A1 VALIDATION OF NATURAL MATRICES FOR THERAPEUTIC USE SOST, FABP4, COL2A1 KDM4E 1247/4885CYP3A4 2659/4885CYP2C9 3265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.