Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Anipamil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.67 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.43 |
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 0.42 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.42 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.42 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.42 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.42 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.42 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.42 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.42 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 0.42 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.42 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 0.42 |
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.42 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.42 |
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anipamil SCHEMBL9177433 | 1.00 | SIGMAR1 (0.67) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| Anipamil SCHEMBL31479919 | 0.99 | SIGMAR1 (0.69) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| Anipamil SCHEMBL247837 | 0.99 | SIGMAR1 (0.69) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| SCHEMBL24224796 | 0.91 | SIGMAR1 (0.60) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| Dagapamil SCHEMBL2110079 | 0.89 | SIGMAR1 (0.60) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| Anipamil SCHEMBL1897642 | 0.84 | SIGMAR1 (0.52) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| SCHEMBL7322417 | 0.82 | CHRM2 (0.46) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| Ronipamil SCHEMBL1814126 | 0.81 | SIGMAR1 (1.00) | SIGMAR1EBPKCNH2SLC6A4CHRM2 | |
| Anipamil SCHEMBL741478 | 0.80 | SCN1A (0.62) | SIGMAR1EBPCYP3A4MEN1KMT2A | |
| SCHEMBL9490822 | 0.79 | SIGMAR1 (0.53) | SIGMAR1EBPCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432196-A | Anipamil | KNOLL AG (DE) | 1995-07-11 | — | — | US | claimed |
| US-6599931-B1 | Mixing bioactive substances with 1,3-bis(1-pyrrolidonyl) butane to form solution/dispersion; assessing spectroscopically; and selecting the bioactive substances that do not recrystallize out of solution/dispersion | ABBOTT GMBH & CO. KG (DE) | 2003-07-29 | — | — | US | disclosed |
| US-6497886-B1 | SOLVENTS FOR PHARMACEUTICAL PREPARATIONS WHICH, BESIDES EXCELLENT DISSOLVING CAPACITY FOR ACTIVE INGREDIENT USED, ALSO PROVIDE EXCELLENT MISCIBILITY WITH OTHER SOLVENTS AND GOOD PHYSIOLOGICAL TOLERABILITY | BASF AKTIENGESELLSCHAFT (DE) | 2002-12-24 | — | — | US | disclosed |
| EP-0641596-B1 | Process for preparing finely divided colouring or active agents | BASF AG (DE) | 1998-12-16 | — | — | EP | disclosed |
| US-5700471-A | CONVERTING COARSE-PARTICLE DISPERSION INTO A COLLOIDAL DISPERSION IN WATER ABOVE MELTING POINT OF DYE OR DRUG; SPRAY DRYING | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-23 | — | — | US | disclosed |
| US-5626864-A | Preparation of colloidal aqueous solutions of active substances of low solubility | KNOLL AKTIENGESELLSCAHFT (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5432196-A | Anipamil | KNOLL AG (DE) | 1995-07-11 | — | — | US | disclosed |
| US-5432196-A | Anipamil | KNOLL AG (DE) | 1995-07-11 | — | — | US | disclosed |
| EP-0641596-A2 | Process for preparing finely divided colouring or active agents | BASF Aktiengesellschaft (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5354561-A | Process for producing solid active substance forms and products thereof | KNOLL AG (DE) | 1994-10-11 | — | — | US | disclosed |
| EP-0595854-A1 | METHOD OF PREPARING A STERILE-FILTERABLE SOLUTION OF AN ACTIVE SUBSTANCE | KNOLL AG (DE) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993001811-A1 | METHOD OF PREPARING A STERILE-FILTERABLE SOLUTION OF AN ACTIVE SUBSTANCE | KNOLL AKTIENGESELLSCHAFT (DE) | 1993-02-04 | — | — | WO | disclosed |
| US-5118511-A | Emulsifier, protective colloid, drug dispersed in very small particles of edible oil or fat | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-02 | — | — | US | disclosed |
| US-4935245-A | DISSOLVED IN SMALL DROPS OF EDIBLE OIL OR FAT | BASF AKTIENGESELLSCHAFT (DE) | 1990-06-19 | — | — | US | disclosed |
| US-4777183-A | Use of anipamil | KNOLL AG (DE) | 1988-10-11 | — | — | US | disclosed |