Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chlorhexidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorhexidine SCHEMBL3616 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL10808378 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL3617 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL3984 | 0.98 | LMNA (0.46) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL1551122 | 0.98 | LMNA (0.46) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL1550787 | 0.98 | LMNA (0.46) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| SCHEMBL6365499 | 0.98 | LMNA (0.46) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL23117798 | 0.97 | LMNA (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL6437831 | 0.97 | LMNA (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A | |
| Chlorhexidine SCHEMBL2478603 | 0.97 | LMNA (0.45) | SMN1; SMN2LMNAHDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 356 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044568-A1 | ANTIMICROBIAL POLYCARBONATE COATINGS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-02-29 | — | — | WO | claimed |
| EP-2322161-B1 | Composition for preventing and treating odontostomatological pathologies of animals | Icf Srl (IT) | 2014-12-31 | — | — | EP | claimed |
| WO-2014020133-A2 | PROCESS AND DEVICE | CRAWFORD HEALTHCARE LTD (GB) | 2014-02-06 | — | — | WO | claimed |
| EP-2322161-A1 | Composition for preventing and treating odontostomatological pathologies of animals | I.C.F. S.r.l. (IT) | 2011-05-18 | — | — | EP | claimed |
| US-7179849-B2 | Antimicrobial compositions containing colloids of oligodynamic metals | C. R. BARD, INC. (US) | 2007-02-20 | — | — | US | claimed |
| US-6517852-B1 | Quick reduction of germs even at low temperature using water and alcohol solution containing an active microbicidal chlor-hexidine compound | ECOLAB GMBH CO. OHG (DE) | 2003-02-11 | — | — | US | claimed |
| US-20020173824-A1 | CARDIO THERAPEUTIC HEART SACK | COSMOS GROUP, LLC | 2002-11-21 | — | — | US | claimed |
| US-20020151950-A1 | Cardio therapeutic heart sack | ACORN CARDIOVASCULAR, INC. | 2002-10-17 | — | — | US | claimed |
| EP-0971591-B1 | DISINFECTION METHOD | ECOLAB GMBH & CO OHG (DE) | 2002-06-05 | — | — | EP | claimed |
| US-6261844-B1 | 10-20% SOLUTION OF CHLORHEXIDINE SALT AND 10-30% SOLUTION OF N-PROPYL GALLATE; USED AT AMBIENT TEMPERATURES; SAFELY HANDLED WITHOUT EXTENSIVE PRECAUTIONARY MEASURES; DOES NOT SUBSTANTIALLY ALTER PH | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | 2001-07-17 | — | — | US | claimed |
| EP-0788305-A4 | COMPOSITION FOR INACTIVATING IRRITANTS IN FLUIDS | UNIV COLUMBIA (US) | 1999-05-26 | — | — | EP | claimed |
| JP-H09510976-A | — | — | 1997-11-04 | — | — | JP | claimed |
| EP-0788305-A1 | COMPOSITION FOR INACTIVATING IRRITANTS IN FLUIDS | The Trustees of Columbia University in the City of New York (US) | 1997-08-13 | — | — | EP | claimed |
| EP-0617611-B1 | ORAL OSMOTIC DEVICE | ALZA CORP (US) | 1996-01-31 | — | — | EP | claimed |
| WO-1995026134-A1 | COMPOSITION FOR INACTIVATING IRRITANTS IN FLUIDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1995-10-05 | — | — | WO | claimed |
| EP-0617611-A1 | ORAL OSMOTIC DEVICE. | ALZA CORP (US) | 1994-10-05 | — | — | EP | claimed |
| WO-1993011748-A1 | ORAL OSMOTIC DEVICE | ALZA CORPORATION (US) | 1993-06-24 | — | — | WO | claimed |
| US-5200194-A | Oral osmotic device | ALZA CORPORATION (US) | 1993-04-06 | — | — | US | claimed |
| WO-2024044568-A1 | ANTIMICROBIAL POLYCARBONATE COATINGS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-02-29 | — | — | WO | disclosed |
| EP-0122085-A1 | Dressing | Smith and Nephew Associated Companies p.l.c. (GB) | 1984-10-17 | — | — | EP | disclosed |