Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 17/20 | 0.44 |
| ▸ | FNTB | P49356 | 17/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 15/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3499837 | 0.99 | FNTA (0.44) | FNTAFNTBPGGT1BBCAT2BCAT1 | |
| Hydrochloric Acid SCHEMBL7527027 | 0.87 | FFAR4 (0.33) | FNTAFNTBPGGT1BBCAT2BCAT1 | |
| SCHEMBL3498917 | 0.86 | FFAR4 (0.34) | FNTAFNTBPGGT1BBCAT2BCAT1 | |
| SCHEMBL7624855 | 0.85 | FNTA (0.38) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7566917 | 0.85 | BCAT2 (0.32) | BCAT2BCAT1 | |
| SCHEMBL7623127 | 0.82 | FNTA (0.37) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7628931 | 0.81 | FNTA (0.37) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7628308 | 0.81 | FNTA (0.41) | FNTAFNTBPGGT1B | |
| SCHEMBL7621679 | 0.81 | FNTA (0.37) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7632603 | 0.79 | MEN1 (0.43) | FNTAFNTBPGGT1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627729-B | 2-amino-6-chloropurine, and synthesis method, intermediate and application thereof | 南京红杉生物科技有限公司 | 2021-04-20 | — | — | CN | claimed |
| EP-0662970-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | claimed |
| WO-1994007892-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | claimed |
| JP-5163124-A | — | — | None | — | — | JP | disclosed |
| CN-118239991-A | Preparation process of high-purity 2-amino-6-chloropurine nucleoside | 甘肃省化工研究院有限责任公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-114621228-B | Preparation method of 2-amino-6-chloropurine | 杭州丰禾生物技术有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-113292507-B | Preparation method of 2-amino-6-chloroguanine and intermediate thereof | 潍坊奥通药业有限公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-114621228-A | Preparation method of 2-amino-6-chloropurine | 杭州丰禾生物技术有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-114437071-A | Process for preparing purine derivatives | 甘肃欣睿泽医药科技有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-113234077-B | Synthesis method of 2-amino-6-chloropurine | 上海凌凯医药科技有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-113292507-A | Preparation method of 2-amino-6-chloroguanine and intermediate thereof | 潍坊奥通药业有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-108892669-B | Method for preparing 2-amino-6-chloropurine | 江苏八巨药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-110627729-A | 2-amino-6-chloropurine, and synthesis method, intermediate and application thereof | 南京红杉生物科技有限公司 | 2019-12-31 | — | — | CN | disclosed |
| EP-0773220-B1 | 2-Amino-6-chloropurine and method for preparing the same | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-02-13 | — | — | EP | disclosed |
| WO-2001060815-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-08-23 | — | — | WO | disclosed |
| EP-0662970-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | disclosed |
| EP-0662970-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007892-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | disclosed |
| WO-1994007892-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | disclosed |
| JP-H05163124-A | KERATIN FIBER DYEING COMPOSITION | KAO CORP | 1993-06-29 | — | — | JP | disclosed |