Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 3/20 | 0.34 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.34 |
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.34 |
| ▸ | MAOB known ✓ | P27338 | 3/20 | 0.34 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.32 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 12/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA6 | P23280 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10934527 | 1.00 | AOC3 (0.38) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| SCHEMBL8487525 | 0.99 | AOC3 (0.39) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| Hydrochloric Acid SCHEMBL11259470 | 0.92 | AOC3 (0.36) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| SCHEMBL11002732 | 0.90 | AOC3 (0.37) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| Hydrochloric Acid SCHEMBL10439042 | 0.88 | HRH2 (0.39) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| Hydrochloric Acid SCHEMBL11236238 | 0.88 | HRH2 (0.39) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| SCHEMBL8411573 | 0.86 | KMT2A (0.35) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| SCHEMBL10587291 | 0.86 | HRH2 (0.39) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| Hydrochloric Acid SCHEMBL10586317 | 0.85 | HRH2 (0.37) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 | |
| Hydrochloric Acid SCHEMBL10390042 | 0.84 | HRH2 (0.38) | AOC3KMT2ASMN1; SMN2HRH2SLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005115-A | HISTAMINE H.SUB.2-RECEPTOR ANTAGONIST, USEFUL IN THERAPY AS AN ACID SECRETION INHIBITOR | FERRER INTERNACIONAL, S.A. (ES) | 1999-12-21 | — | — | US | claimed |
| EP-0738721-A1 | FORMS A AND B OF N-[[[2-[[[2-[(DIAMINOMETHYLEN)AMINO]-4-THIAZOLYL]METHYL]THIO]ETHYL]AMINO]METHYLEN]-4-BROMOBENZENOSULPHONAMIDE | FERRER INTERNACIONAL, S.A. (ES) | 1996-10-23 | — | — | EP | claimed |
| US-6005115-A | HISTAMINE H.SUB.2-RECEPTOR ANTAGONIST, USEFUL IN THERAPY AS AN ACID SECRETION INHIBITOR | FERRER INTERNACIONAL, S.A. (ES) | 1999-12-21 | — | — | US | disclosed |
| EP-0738721-A1 | FORMS A AND B OF N-[[[2-[[[2-[(DIAMINOMETHYLEN)AMINO]-4-THIAZOLYL]METHYL]THIO]ETHYL]AMINO]METHYLEN]-4-BROMOBENZENOSULPHONAMIDE | FERRER INTERNACIONAL, S.A. (ES) | 1996-10-23 | — | — | EP | disclosed |
| US-5120746-A | Inhibit gastric acid secretion | TOYAMA CHEMICAL CO., LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| US-4923882-A | Novel amine derivatives, salts thereof and an anti-ulcer agent containing the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1990-05-08 | — | — | US | disclosed |
| EP-0159012-B1 | SULFONAMIDINES, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FERRER INTERNACIONAL, S.A. (ES) | 1989-02-01 | — | — | EP | disclosed |
| US-4742055-A | ANTISECRETORY, ANTIULCER | RORER PHARMACEUTICAL CORPORATION (US) | 1988-05-03 | — | — | US | disclosed |
| US-4728655-A | ANTIULCER, H2-ANTAGONISTS | FERRER INTERNACIONAL S.A. (ES) | 1988-03-01 | — | — | US | disclosed |
| US-4649145-A | ANTISECRETORY, ANTIULCER, HISTAMINE H-2 ANTAGONIST | HOECHST UK LIMITED (GB) | 1987-03-10 | — | — | US | disclosed |
| US-4643849-A | ANTIULCER, ANTISECRETORY AGENTS | TOYAMA CHEMICAL CO., LTD. (JP) | 1987-02-17 | — | — | US | disclosed |
| US-4359466-A | Guanidine compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-11-16 | — | — | US | disclosed |
| US-4347370-A | HISTAMINE H-2 ANTAGONISTS, INHIBIT GASTRIC ACID SECRETION | IMPERIAL CHEMICAL INDUSTRIES LTD. (GB) | 1982-08-31 | — | — | US | disclosed |
| US-4309435-A | HISTAMINE ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES LTD. (GB) | 1982-01-05 | — | — | US | disclosed |
| EP-0039989-A1 | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-11-18 | — | — | EP | disclosed |
| EP-0028117-A1 | Guanidine compounds, process for preparing them and compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-05-06 | — | — | EP | disclosed |
| US-4262126-A | INHIBIT SECRETION OF GASTRIC JUICE | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-04-14 | — | — | US | disclosed |
| EP-0015138-A1 | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-03 | — | — | EP | disclosed |
| EP-0010418-A1 | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-30 | — | — | EP | disclosed |
| US-4165378-A | ANTISECRETORY, ANTIHISTAMINE | ICI AMERICAS INC. (US) | 1979-08-21 | — | — | US | disclosed |