Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.43 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714706 | 0.98 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| Bicarbonate SCHEMBL9222817 | 0.96 | ALDH1A1 (0.52) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| SCHEMBL14691493 | 0.96 | ALDH1A1 (0.52) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL9332412 | 0.94 | RARB (0.50) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7777364 | 0.94 | RARB (0.50) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| SCHEMBL7778466 | 0.92 | RARB (0.51) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| SCHEMBL11568621 | 0.92 | SRD5A2 (0.58) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| Chavicol SCHEMBL11555429 | 0.90 | CA2 (0.59) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| SCHEMBL11875227 | 0.84 | MAPT (0.42) | ALDH1A1TP53TSHRMAPTL3MBTL1 | |
| Paraben SCHEMBL28138195 | 0.83 | CA12 (0.55) | TSHRHSD17B10SRD5A2NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58013561-A | — | — | None | — | — | JP | disclosed |
| JP-61050953-A | — | — | None | — | — | JP | disclosed |
| EP-0632116-B1 | A smectic C liquid crystal composition and a liquid crystal display element | CHISSO CORP (JP) | 1999-09-08 | — | — | EP | disclosed |
| US-5658492-A | POSITIONING LIQUID CRYSTAL BETWEEN THE PAIR OF INSULATING SUBSTRATE, EACH HAVING AN ELECTRODE, SELECTIVELY IMPRESSING A VOLTAGE ONTO SAID ELECTRODE | CHISSO CORPORATION (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5529717-A | CONTAINING DIPHENYLTHIADIAZOLE AND ALKOXYPHENYLPYRIDINE COMPOUNDS | CHISSO CORPORATION (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0632116-A1 | A smectic C liquid crystal composition and a liquid crystal display element | CHISSO CORPORATION (JP) | 1995-01-04 | — | — | EP | disclosed |
| EP-0256307-B1 | OPTICALLY ACTIVE COMPOUNDS HAVING BIPHENYL SKELETON, LIQUID CRYSTAL COMPOSITION AND SWITCHING ELEMENT CONTAINING THEM | Chisso Corporation (JP) | 1990-10-03 | — | — | EP | disclosed |
| US-4820444-A | SUPERIOR FERROELECTRIC MATERIAL | CHISSO CORPORATION (JP) | 1989-04-11 | — | — | US | disclosed |
| EP-0256307-A1 | Optically active compounds having biphenyl skeleton, liquid crystal composition and switching element containing them | Chisso Corporation (JP) | 1988-02-24 | — | — | EP | disclosed |
| EP-0115693-B1 | LIQUID CRYSTALLINE COMPOUNDS AND MIXTURES THEREOF | Chisso Corporation (JP) | 1987-08-26 | — | — | EP | disclosed |
| US-4676925-A | Liquid crystalline biphenyl derivatives and mixtures thereof | CHISSO CORPORATION (JP) | 1987-06-30 | — | — | US | disclosed |
| EP-0131373-B1 | LIQUID CRYSTALLINE BIPHENYL DERIVATIVES AND MIXTURES THEREOF | Chisso Corporation (JP) | 1986-12-30 | — | — | EP | disclosed |
| US-4614609-A | FERROELECTRICITY; DISPLAY ELEMENTS | CHISSO CORPORATION (JP) | 1986-09-30 | — | — | US | disclosed |
| US-4596667-A | Phenyl ester derivatives | CHISSO CORPORATION (JP) | 1986-06-24 | — | — | US | disclosed |
| JP-S6150953-A | 4-ALKYLBENZOIC ACID 3-FLUORO-4-CYANOPHENYL ESTER | CHISSO CORP | 1986-03-13 | — | — | JP | disclosed |
| EP-0131373-A1 | Liquid crystalline biphenyl derivatives and mixtures thereof | Chisso Corporation (JP) | 1985-01-16 | — | — | EP | disclosed |
| EP-0115693-A2 | Liquid crystalline compounds and mixtures thereof | Chisso Corporation (JP) | 1984-08-15 | — | — | EP | disclosed |
| JP-S5813561-A | LIQUID CRYSTAL ADDITIVE HAVING POSITIVE DIELECTRIC ANISOTROPY | CHISSO CORP | 1983-01-26 | — | — | JP | disclosed |