Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 known ✓ | P34969 | 7/20 | 0.37 |
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.35 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.31 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8988088 | 0.98 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KDM4EGFERHTR7 | |
| Hydrochloric Acid SCHEMBL9328999 | 0.94 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KDM4EGFERHTR7 | |
| SCHEMBL5173153 | 0.88 | HTR7 (0.47) | ALDH1A1SMN1; SMN2KDM4EGFERHTR7 | |
| Hydrochloric Acid SCHEMBL9330350 | 0.84 | HTR7 (0.38) | ALDH1A1SMN1; SMN2KDM4EGFERHTR7 | |
| SCHEMBL12716522 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2APEX1HTTNPSR1 | |
| SCHEMBL3247846 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KDM4EAPEX1HTT | |
| SCHEMBL10011623 | 0.77 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2APEX1CYP1A2 | |
| SCHEMBL10012862 | 0.76 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2APEX1CYP1A2 | |
| SCHEMBL10709713 | 0.76 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2APEX1CYP1A2 | |
| SCHEMBL16378564 | 0.75 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2APEX1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439041-B1 | Direct positive photographic material | FUJI PHOTO FILM CO LTD (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5601964-A | CONTAINING HYDRAZINE-TYPE NUCLEATING COMPOUND; HIGH CONTRAST NEGATIVE IMAGES, DIRECT POSITIVES; QUALITY | FUJI PHOTO FILM CO., LTD. (JP) | 1997-02-11 | — | — | US | disclosed |
| EP-0399460-B1 | Silver halide photograpic material | FUJI PHOTO FILM CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| EP-0283040-B1 | Silver halide photographic material | FUJI PHOTO FILM CO LTD (JP) | 1995-06-21 | — | — | EP | disclosed |
| EP-0355818-B1 | Silver halide color photographic material | FUJI PHOTO FILM CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| EP-0358170-B1 | Direct positive photographic materials | FUJI PHOTO FILM CO LTD (JP) | 1994-08-24 | — | — | EP | disclosed |
| US-5338658-A | Nucleation agent | FUJI PHOTO FILM CO., LTD. (JP) | 1994-08-16 | — | — | US | disclosed |
| US-5336590-A | For obtaining dupe negatives of high image quality | FUJI PHOTO FILM CO., LTD. (JP) | 1994-08-09 | — | — | US | disclosed |
| EP-0322702-B1 | Direct positive photographic materials | FUJI PHOTO FILM CO LTD (JP) | 1994-07-20 | — | — | EP | disclosed |
| EP-0294769-B1 | Method for processing silver halide color photographic light-sensitive materials | FUJI PHOTO FILM CO LTD (JP) | 1994-03-02 | — | — | EP | disclosed |
| EP-0318987-A1 | Direct positive photographic lightsensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-06-07 | — | — | EP | disclosed |
| EP-0315890-A1 | Method for forming a direct positive image | FUJI PHOTO FILM CO., LTD. (JP) | 1989-05-17 | — | — | EP | disclosed |
| US-4830948-A | Method of forming color images | FUJI PHOTO FILM CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| EP-0303301-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |
| EP-0294785-A2 | Magenta dye-forming coupler | FUJI PHOTO FILM CO., LTD. (JP) | 1988-12-14 | — | — | EP | disclosed |
| EP-0286840-A1 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-19 | — | — | EP | disclosed |
| EP-0285010-A2 | Method for forming a direct positive color image | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0276842-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |
| EP-0267482-A2 | Direct positive color photosensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-05-18 | — | — | EP | disclosed |
| EP-0254280-A2 | Method for processing silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-01-27 | — | — | EP | disclosed |