Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.35 |
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.34 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | GFER | P55789 | 3/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486360 | 0.84 | ACHE (0.31) | TSHRACHESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11681238 | 0.78 | GAA (0.40) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL11734473 | 0.76 | CHRNB2 (0.35) | LMNASMN1; SMN2 | |
| SCHEMBL9712020 | 0.74 | ACHE (0.44) | MAPTTDP1ALDH1A1TSHRACHE | |
| Hydrochloric Acid SCHEMBL11582669 | 0.73 | ACHE (0.44) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL31325828 | 0.73 | MAOB (0.45) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL10657323 | 0.72 | TP53 (0.43) | TDP1ALDH1A1TSHRMAPK1L3MBTL1 | |
| Water SCHEMBL7200805 | 0.72 | ACHE (0.42) | MAPTTDP1ALDH1A1TSHRACHE | |
| Bromide SCHEMBL123535 | 0.72 | ACHE (0.42) | MAPTMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL7553593 | 0.72 | ACHE (0.42) | MAPTTDP1ALDH1A1TSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570974-B1 | Color photographic materials and methods containing DIR or DIAR couplers and carbonamide coupler solvents | EASTMAN KODAK CO (US) | 1998-11-18 | — | — | EP | disclosed |
| EP-0529736-B1 | Color photographic materials including magenta coupler, inhibitor-releasing coupler an carbonamide compound | EASTMAN KODAK CO (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0529727-B1 | Color photographic materials including magenta coupler, carbonamide compound & aniline or amine compound | EASTMAN KODAK CO (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5462848-A | Phenylenediamide(tert-) controls coupling during bleaching step | EASTMAN KODAK COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0573854-B1 | Color photographic materials and methods with stabilized silver chloride emulsions | EASTMAN KODAK CO (US) | 1995-10-04 | — | — | EP | disclosed |
| US-5451496-A | Color photographic materials and methods containing DIR or DIAR couplers and phenolic coupler solvents | EASTMAN KODAK COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5378593-A | DIR=development inhibitor releasing couplers; DIAR=timed development inhibiting releasing couplers | EASTMAN KODAK COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| US-5356770-A | Diaminodisulfides and sulfinates for storage stability and reduced heat sensitivity | EASTMAN KODAK COMPAMN (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0583832-A1 | Color photographic materials containing 5-pyrazolone polymeric couplers and solvents | EASTMAN KODAK COMPANY (US) | 1994-02-23 | — | — | EP | disclosed |
| EP-0583834-A1 | Color photographic materials containing 5-pyrazolone polymeric couplers | EASTMAN KODAK COMPANY (US) | 1994-02-23 | — | — | EP | disclosed |
| EP-0573854-A1 | Color photographic materials and methods with stabilized silver chloride emulsions | EASTMAN KODAK COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |
| EP-0570974-A1 | Color photographic materials and methods containing DIR or DIAR couplers and carbonamide coupler solvents | EASTMAN KODAK COMPANY (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5250405-A | Reduction of continued coupling | EASTMAN KODAK COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5200309-A | Wherein carbonamide and aniline or amine compounds reduce cont continued coupling of pyrazolone magenta dye forming coupler during bleaching | EASTMAN KODAK COMPANY (US) | 1993-04-06 | — | — | US | disclosed |
| EP-0529727-A1 | Color photographic materials including magenta coupler, carbonamide compound & aniline or amine compound | EASTMAN KODAK COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| EP-0529736-A1 | Color photographic materials including magenta coupler, inhibitor-releasing coupler an carbonamide compound | EASTMAN KODAK COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |