SCHEMBL893601

SCHEMBL893601

O=C(O)C(OCC(F)(F)F)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.44
PPARG P37231 6/20 0.41
PPARA Q07869 5/20 0.41
CYP2D6 P10635 1/20 0.41
SRC P12931 1/20 0.41
LMNA P02545 2/20 0.39
MAPK1 P28482 1/20 0.39
FABP7 O15540 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5640880 1.00 PDPK1 (0.44) PDPK1PPARGPPARACYP2D6SRC
SCHEMBL5642476 1.00 PDPK1 (0.44) PDPK1PPARGPPARACYP2D6SRC
Hydrochloric Acid SCHEMBL8847169 0.98 PDPK1 (0.43) PDPK1PPARGPPARACYP2D6SRC
Hydrochloric Acid SCHEMBL668327 0.98 PDPK1 (0.43) PDPK1PPARGPPARACYP2D6SRC
SCHEMBL7344512 0.86 EPHX2 (0.41) PPARGPPARALMNAEPHX2
SCHEMBL11825339 0.86 EPHX1 (0.41) PDPK1CYP2D6LMNAMAPK1FABP7
SCHEMBL527394 0.86 PDPK1 (0.39) PDPK1PPARGPPARALMNAFABP7
SCHEMBL7341580 0.84 PNMT (0.51) PPARGPPARA
SCHEMBL8171416 0.83 KMT2A (0.50) LMNA
SCHEMBL7344139 0.83 MEN1 (0.48) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 293 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115297858-B Pharmaceutical composition for treating hypertrophic cardiomyopathy and treatment method using the same 赛特瑞恩股份有限公司 2024-08-13 CN claimed
US-20230190708-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION CELLTRION, INC. (KR) 2023-06-22 US claimed
EP-4140482-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION Celltrion, Inc. (KR) 2023-03-01 EP claimed
CN-115297858-A Pharmaceutical composition for treating hypertrophic cardiomyopathy and treatment method using same 赛特瑞恩股份有限公司 2022-11-04 CN claimed
EP-3440065-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST EUROAPI HUNGARY LLC (HU) 2022-06-08 EP claimed
US-10421737-B2 Process for the preparation of optically active Beraprost CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS PRIVATE COMPANY LTD. (HU) 2019-09-24 US claimed
EP-3140265-B1 PROCESS FOR OBTAINING OPTICALLY ACTIVE PIRLINDOLE ENANTIOMERS AND SALTS THEREOF TECNIMEDE SOCIEDADE TECNICO MEDICINAL S (PT) 2019-08-28 EP claimed
EP-3440065-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST Chinoin Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2019-02-13 EP claimed
WO-2017174439-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2017-10-12 WO claimed
US-8653283-B2 Anticancer agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-18 US claimed
EP-2331545-B1 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE&NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LTD (IN) 2013-10-02 EP claimed
EP-1598337-B1 METHOD OF OBTAINING AN ANTIEPILEPTIC AGENT ESTEVE QUIMICA SA (ES) 2012-05-09 EP claimed
US-20120083527-A1 Anticancer Agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-04-05 US claimed
US-20110213149-A1 PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LIMITED (IN) 2011-09-01 US claimed
EP-2331545-A2 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE&NEW IMPURITIES IN PREPARATION THEREOF Cadila Healthcare Limited (IN) 2011-06-15 EP claimed
WO-2010032264-A2 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LIMITED (IN) 2010-03-25 WO claimed
US-7291746-B2 Process for obtaining an antiepileptic agent ESTEVE QUIMICA, S.A. (ES) 2007-11-06 US claimed
US-20060142376-A1 Method for obtaining an antiepileptic agent ESTEVE QUIMICA, S.A. (ES) 2006-06-29 US claimed
EP-1598337-A1 METHOD OF OBTAINING AN ANTIEPILEPTIC AGENT Farma-Lepori S.A. (ES) 2005-11-23 EP claimed
EP-4469466-A1 C25 R AND S ISOMERS OF AMINOSTEROLS AND METHODS OF MAKING AND USING THE SAME Enterin, Inc. (US) 2024-12-04 EP disclosed
CN-115297858-B Pharmaceutical composition for treating hypertrophic cardiomyopathy and treatment method using the same 赛特瑞恩股份有限公司 2024-08-13 CN disclosed
WO-2023146842-A1 C25 R AND S ISOMERS OF AMINOSTEROLS AND METHODS OF MAKING AND USING THE SAME ENTERIN, INC. (US) 2023-08-03 WO disclosed
US-20230190708-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION CELLTRION, INC. (KR) 2023-06-22 US disclosed
EP-4140482-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION Celltrion, Inc. (KR) 2023-03-01 EP disclosed
CN-109219601-B Method for preparing optically active beraprost 奇诺因药物和化学工厂私人有限公司 2022-08-09 CN disclosed
EP-4022293-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD Merck Patent GmbH (DE) 2022-07-06 EP disclosed
EP-3440065-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST EUROAPI HUNGARY LLC (HU) 2022-06-08 EP disclosed
US-11168249-B1 Luminescent polydentate polycyclic compounds for metal ions ZAVALETA FERNANDEZ DE CORDOVA ANDRES (US) 2021-11-09 US disclosed
EP-3862354-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2021-08-11 EP disclosed
US-11021445-B2 Carboxylic acid derivative as AT2R receptor antagonist SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-06-01 US disclosed
EP-3620454-B1 CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-05 EP disclosed
WO-2021037362-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD MERCK PATENT GMBH (DE) 2021-03-04 WO disclosed
WO-2021037937-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD MERCK PATENT GMBH (DE) 2021-03-04 WO disclosed
EP-3786623-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD Merck Patent GmbH (DE) 2021-03-03 EP disclosed
US-20200231562-A1 NOVEL MACROLIDE ANTIBIOTICS LEIBNIZ-INSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. (HKI) (DE) 2020-07-23 US disclosed
US-10633586-B1 Luminescent polydentate polycyclic compounds for metal ions ZAVALETA FERNANDEZ DE CORDOVA ANDRES (US) 2020-04-28 US disclosed
WO-2020067684-A1 NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE (주)셀트리온 2020-04-02 WO disclosed
US-20200102275-A1 CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-02 US disclosed
US-10421737-B2 Process for the preparation of optically active Beraprost CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS PRIVATE COMPANY LTD. (HU) 2019-09-24 US disclosed
EP-3080121-B1 FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY UCB BIOPHARMA SPRL (BE) 2019-09-04 EP disclosed
EP-3140265-B1 PROCESS FOR OBTAINING OPTICALLY ACTIVE PIRLINDOLE ENANTIOMERS AND SALTS THEREOF TECNIMEDE SOCIEDADE TECNICO MEDICINAL S (PT) 2019-08-28 EP disclosed
EP-3273936-B1 PEARLY LUSTER CONCENTRATES IN AQUEOUS MEDIA CONTAINING SURFACTANTS BASF SE (DE) 2019-05-08 EP disclosed
US-10259779-B2 Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity WAYNE STATE UNIVERSITY (US) 2019-04-16 US disclosed
EP-3440065-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST Chinoin Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2019-02-13 EP disclosed
US-10125074-B2 5-substituted-5-hydroxy-5-aryl-3-oxo-pentanoate derivatives and their enantiopure forms OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION (JP) 2018-11-13 US disclosed
EP-3166934-B1 NOVEL MACROLIDE ANTIBIOTICS HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) 2018-05-23 EP disclosed
US-9962377-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2018-05-08 US disclosed
US-20180118648-A1 5-SUBSTITUTED-5-HYDROXY-5-ARYL-3-OXO-PENTANOATE DERIVATIVES AND THEIR ENANTIOPURE FORMS OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION (JP) 2018-05-03 US disclosed
US-20180057448-A1 Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity WAYNE STATE UNIVERSITY 2018-03-01 US disclosed
US-9823199-B1 Luminescent polydentate polycyclic compounds for metal ions Zavaleta Fernandez de Cordova, Andres Nildo (US) 2017-11-21 US disclosed
WO-2017174439-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2017-10-12 WO disclosed
EP-3191464-A1 SYNTHESIS OF ISOFLAVANES AND INTERMEDIATES THEREOF System Biologie AG (CH) 2017-07-19 EP disclosed
EP-3166934-A1 NOVEL MACROLIDE ANTIBIOTICS Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2017-05-17 EP disclosed
EP-3080121-A1 FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY UCB Biopharma SPRL (BE) 2016-10-19 EP disclosed
EP-2268640-B1 PROCESS FOR PREPARING ENANTIOMERICALLY PURE INDOLOPYRIDINES 4SC AG (DE) 2016-10-12 EP disclosed
US-20160279120-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS TAKEDA GMBH (DE) 2016-09-29 US disclosed
WO-2016151990-A1 5-SUBSTITUTED-5-HYDROXY-5-ARYL-3-OXO-PENTANOATE DERIVATIVES AND THEIR ENANTIOPURE FORMS OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION (JP) 2016-09-29 WO disclosed
US-9387205-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2016-07-12 US disclosed
US-20160185729-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES ARENA PHARMACEUTICALS, INC. 2016-06-30 US disclosed
WO-2016038061-A1 SYNTHESIS OF ISOFLAVANES AND INTERMEDIATES THEREOF SYSTEM BIOLOGIE AG (CH) 2016-03-17 WO disclosed
EP-2332921-B1 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride ARENA PHARM INC (US) 2016-03-02 EP disclosed
WO-2016005049-A1 NOVEL MACROLIDE ANTIBIOTICS Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2016-01-14 WO disclosed
US-20150352096-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-12-10 US disclosed
US-9149479-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2015-10-06 US disclosed
US-9102627-B2 Processes for preparing 3-benzazepines ARENA PHARMACEUTICALS, INC. 2015-08-11 US disclosed
WO-2015086525-A1 FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY UCB BIOPHARMA SPRL (BE) 2015-06-18 WO disclosed
US-20150119389-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-04-30 US disclosed
US-8946207-B2 Processes for preparing 3-benzazepines ARENA PHARMACEUTICALS, INC. (US) 2015-02-03 US disclosed
EP-2824105-A1 Indolopyridines as Eg5 kinesin modulators 4SC AG (DE) 2015-01-14 EP disclosed
US-8883818-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2014-11-11 US disclosed
EP-2589599-B1 Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2014-06-25 EP disclosed
US-20140073636-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS TAKEDA GMBH (DE) 2014-03-13 US disclosed
US-8653283-B2 Anticancer agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-18 US disclosed
EP-2189448-B1 Processes for the Separation of 3-Benzazepine Racemates ARENA PHARM INC (US) 2014-01-29 EP disclosed
US-8557991-B2 Process for preparing enantiomerically pure indolopyridines 4SC AG (DE) 2013-10-15 US disclosed
EP-2331545-B1 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE&NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LTD (IN) 2013-10-02 EP disclosed
US-8530493-B2 Indolopyridines as Eg5 kinesin modulators 4SC AG (DE) 2013-09-10 US disclosed
US-20130178620-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES ARENA PHARMACEUTICALS, INC. 2013-07-11 US disclosed
US-8476437-B2 Process for preparation of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine and new impurities in preparation thereof CADILA HEALTHCARE LIMITED (IN) 2013-07-02 US disclosed
US-20130165648-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES ARENA PHARMACEUTICALS, INC. 2013-06-27 US disclosed
EP-1723135-B1 NOVEL HYDROXY-6-HEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS TAKEDA GMBH (DE) 2013-06-19 EP disclosed
US-8455653-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors TAKEDA GMBH (DE) 2013-06-04 US disclosed
WO-2013065066-A1 PROCESSES FOR PREPARING 4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6- DIHYDRO [L,2,41-TRIAZOLO[43-A]PYRAZIN-7(8H)-YL]-L-(2,4,5- TRIFLUOROPHENYL)BUTAN-2-AMINE CADILA HEALTHCARE LIMITED (IN) 2013-05-10 WO disclosed
EP-2589599-A1 Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors Takeda GmbH (DE) 2013-05-08 EP disclosed
US-20130045974-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS NYCOMED GMBH (DE) 2013-02-21 US disclosed
US-8367657-B2 Processes for preparing 3-benzazepines ARENA PHARMACEUTICALS, INC. (US) 2013-02-05 US disclosed
EP-1720835-B1 NOVEL GUANIDINYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AS EFFECTIVE PHOSPHODIESTERASE (PDE) 4 INHIBITORS NYCOMED GMBH (DE) 2012-12-12 EP disclosed
US-8329906-B2 Guanidinyl-substituted hydroxy-6-phenylphenanthridines NYCOMED GMBH (DE) 2012-12-11 US disclosed
US-8324391-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors NYCOMED GMBH (DE) 2012-12-04 US disclosed
US-8318944-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors NYCOMED GMBH (DE) 2012-11-27 US disclosed
US-8202880-B2 3-hydroxy-6-phenylphenanthridines as PDE4 inhibitors NYCOMED GMBH (DE) 2012-06-19 US disclosed
EP-1598337-B1 METHOD OF OBTAINING AN ANTIEPILEPTIC AGENT ESTEVE QUIMICA SA (ES) 2012-05-09 EP disclosed
US-20120083527-A1 Anticancer Agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-04-05 US disclosed
US-20110257169-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS NYCOMED GMBH (DE) 2011-10-20 US disclosed
US-20110257221-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS NYCOMED GMBH (DE) 2011-10-20 US disclosed
US-20110213149-A1 PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LIMITED (IN) 2011-09-01 US disclosed
US-8003798-B2 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors NYCOMED GMBH (DE) 2011-08-23 US disclosed
EP-2332919-A2 Processes for preparing 3-benzazepines Arena Pharmaceuticals, Inc. (US) 2011-06-15 EP disclosed
EP-2332920-A2 Processes for preparing 3-benzazepines Arena Pharmaceuticals, Inc. (US) 2011-06-15 EP disclosed
EP-2332921-A1 Processes for the Separation of 3-Benzazepine Racemates Arena Pharmaceuticals, Inc. (US) 2011-06-15 EP disclosed
EP-2331545-A2 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE&NEW IMPURITIES IN PREPARATION THEREOF Cadila Healthcare Limited (IN) 2011-06-15 EP disclosed
US-20110077404-A1 PROCESS FOR PREPARING ENANTIOMERICALLY PURE INDOLOPYRIDINES 4SC AG (DE) 2011-03-31 US disclosed
US-7893268-B2 Epithiolone analogues UNIVERSITY OF TOLEDO (US) 2011-02-22 US disclosed
US-20110027226-A1 INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) 4SC AG (DE) 2011-02-03 US disclosed
US-20100285149-A1 NOVEL TETRAHYDROPYRIDOTHIOPHENES 4SC AG (DE) 2010-11-11 US disclosed
EP-2189448-A1 Processes for the Separation of 3-Benzazepine Racemates Arena Pharmaceuticals, Inc. (US) 2010-05-26 EP disclosed
US-20100104659-A1 BENZOPYRANOPYRAZOLES 4SC AG (DE) 2010-04-29 US disclosed
EP-2178875-A1 INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 ) 4SC AG (DE) 2010-04-28 EP disclosed
WO-2010032264-A2 IMPROVED PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF CADILA HEALTHCARE LIMITED (IN) 2010-03-25 WO disclosed
EP-1846390-B1 NOVEL 6-PYRIDYLPHENANTHRIDINES NYCOMED GMBH (DE) 2010-03-17 EP disclosed
US-20100035913-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiestrase (PDE) 4 inhibitors NYCOMED GMBH (DE) 2010-02-11 US disclosed
US-7632844-B2 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors NYCOMED GMBH (DE) 2009-12-15 US disclosed
US-20090258904-A1 Epithiolone Analogues UNIVERSITY OF TOLEDO 2009-10-15 US disclosed
US-20090246169-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS NYCOMED GMBH (DE) 2009-10-01 US disclosed
US-20090233902-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2009-09-17 US disclosed
US-7585872-B2 Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors NYCOMED GMBH (DE) 2009-09-08 US disclosed
US-20090170892-A1 3-Hydroxy-6-phenylphenanthridines as pde4 inhibitors NYCOMED GMBH (DE) 2009-07-02 US disclosed
WO-2009074677-A2 PYRAZOLOTRIAZINES 4SC AG (DE) 2009-06-18 WO disclosed
EP-2070932-A1 Pyrazolotriazines 4SC AG (DE) 2009-06-17 EP disclosed
EP-2051983-A1 NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER 4SC AG (DE) 2009-04-29 EP disclosed
EP-2041141-A2 BENZOPYRANOPYRAZOLES 4SC AG (DE) 2009-04-01 EP disclosed
EP-2035426-A1 PYRAZOLOPYRIMIDONES 4SC AG (DE) 2009-03-18 EP disclosed
EP-2033962-A1 Tetracyclic indolopyridines as EG5 inhibitors 4SC AG (DE) 2009-03-11 EP disclosed
WO-2009024613-A1 TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS 4SC AG (DE) 2009-02-26 WO disclosed
WO-2009024190-A1 INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 ) 4SC AG (DE) 2009-02-26 WO disclosed
US-20080319067-A1 2-Hydroxy-6-phenylphenanthridines as PDE-4 inhibitors NYCOMED GMBH 2008-12-25 US disclosed
EP-1996592-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS Nycomed GmbH (DE) 2008-12-03 EP disclosed
EP-1994033-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2008-11-26 EP disclosed
US-7423046-B2 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors NYCOMED GMBH (DE) 2008-09-09 US disclosed
US-20080214536-A1 Amido-Substituted 6-Phenylphenanthridines NYCOMED GMBH (DE) 2008-09-04 US disclosed
US-20080167316-A1 6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders ALTANA PHARMA AG (DE) 2008-07-10 US disclosed
US-20080167301-A1 Respiratory system disorders ALTANA PHARMA AG (DE) 2008-07-10 US disclosed
US-20080161339-A1 Novel Thio-Containing Hydroxy-6-Phenylphenanthridines and their Use as Pde4 Inhibitors ALTANA PHARMA AG (DE) 2008-07-03 US disclosed
US-20080119505-A1 Novel 6-Pyridylphenanthridines ALTANA PHARMA AG (DE) 2008-05-22 US disclosed
EP-1250325-B1 PHENANTHRIDINE-N-OXIDES NYCOMED GMBH (DE) 2008-05-07 EP disclosed
US-20080045502-A1 Processes for Preparing 3-Benzazepines ARENA PHARMACEUTICALS, INC. (US) 2008-02-21 US disclosed
WO-2008020024-A1 NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER 4SC AG (DE) 2008-02-21 WO disclosed
US-7329676-B2 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors NYCOMED GMBH (DE) 2008-02-12 US disclosed
WO-2008006883-A2 BENZOPYRANOPYRAZOLES 4SC AG (DE) 2008-01-17 WO disclosed
WO-2007144384-A1 PYRAZOLOPYRIMIDONES 4SC AG (DE) 2007-12-21 WO disclosed
EP-1858880-A1 AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES Nycomed GmbH (DE) 2007-11-28 EP disclosed
EP-1856092-A1 6-HETEROARYL-1,2,3,4,4A,10B-HEXAHYDRO-PHENANTHRIDINES AS PDE-4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS Nycomed GmbH (DE) 2007-11-21 EP disclosed
US-20070259909-A1 Novel Difluoroethoxy-Substituted Hydroxy-6-Phenylphenanthridines and Their Use as Pde4 Inhibitors ALTANA PHARMA AG (DE) 2007-11-08 US disclosed
US-7291746-B2 Process for obtaining an antiepileptic agent ESTEVE QUIMICA, S.A. (ES) 2007-11-06 US disclosed
WO-2007096395-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2007-08-30 WO disclosed
WO-2007096393-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2007-08-30 WO disclosed
US-20070191414-A1 Novel isoamido-substituted hydroxy-6-phenylphenanthridines ALTANA PHARMA AG (DE) 2007-08-16 US disclosed
US-20070191413-A1 Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors ATLANTA PHARMA AG (DE) 2007-08-16 US disclosed
US-20070185149-A1 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors ALTANA PHARMA AG (DE) 2007-08-09 US disclosed
EP-1812400-A1 NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2007-08-01 EP disclosed
US-20070167482-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors ALTANA PHARMA AG (DE) 2007-07-19 US disclosed
EP-1163226-B1 POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2007-03-14 EP disclosed
WO-2007015929-A2 EPOTHILONE ANALOGUES UNIVERSITY OF TOLEDO (US) 2007-02-08 WO disclosed
EP-1745025-A2 NOVEL ISOAMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2007-01-24 EP disclosed
EP-1539164-B1 2-HYDROXY-6-PHENYLPHENANTHRIDINES AS PDE-4 INHIBITORS ALTANA PHARMA AG (DE) 2006-12-20 EP disclosed
EP-1725533-A1 NOVEL THIO CONTAINING HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2006-11-29 EP disclosed
EP-1723135-A1 NOVEL HYDROXY-6-HEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2006-11-22 EP disclosed
WO-2006095009-A1 AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES NYCOMED GMBH (DE) 2006-09-14 WO disclosed
WO-2006092417-A1 6 -HETEROARYL-1, 2, 3,4,4A, 1OB-HEXAHYDRO-PHENANTHRIDINES AS PDE-4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS NYCOMED GMBH (DE) 2006-09-08 WO disclosed
US-20060189645-A1 Novel 6-phenylphenantridines ALTANA PHARMA AG (DE) 2006-08-24 US disclosed
US-20060142376-A1 Method for obtaining an antiepileptic agent ESTEVE QUIMICA, S.A. (ES) 2006-06-29 US disclosed
US-20060116518-A1 Novel phenanthridines ALTANA PHARMA AG (DE) 2006-06-01 US disclosed
EP-1650193-A2 6-Phenylphenanthridines with PDE-IV inhibiting activity ALTANA Pharma AG (DE) 2006-04-26 EP disclosed
EP-1147089-B1 PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2005-12-07 EP disclosed
EP-1598337-A1 METHOD OF OBTAINING AN ANTIEPILEPTIC AGENT Farma-Lepori S.A. (ES) 2005-11-23 EP disclosed
US-20050239818-A1 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors ALANA PHARMA AG (DE) 2005-10-27 US disclosed
US-20050239817-A1 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors ALTANA PHARMA AG (DE) 2005-10-27 US disclosed
WO-2005090311-A1 NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-29 WO disclosed
WO-2005087744-A1 NOVEL THIO-CONTAINING HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-22 WO disclosed
WO-2005085225-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-15 WO disclosed
WO-2005084104-A2 NOVEL ISOAMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-15 WO disclosed
US-20050153358-A1 High-throughput screening method for determining the enantioselectivity of catalysts, biocatalysts, and agents STUDIENGESELLSCHAFT KOHLE MBH (DE) 2005-07-14 US disclosed
US-20050154051-A1 Method for the preparation of escitalopram H. LUNDBECK A/S (DK) 2005-07-14 US disclosed
EP-1147087-B1 PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2005-05-11 EP disclosed
EP-1147103-B1 PHENANTRHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2005-05-04 EP disclosed
US-6884802-B2 6-heteroarylphenanthridines ALTANA PHARMA AG (DE) 2005-04-26 US disclosed
EP-1458701-A1 METHOD FOR THE PREPARATION OF ESCITALOPRAM H. Lundbeck A/S (DK) 2004-09-22 EP disclosed
US-20040038979-A1 Treating airway disorders such as asthma. ALTANA PHARMA AG (DE) 2004-02-26 US disclosed
US-6630483-B2 Phenanthridine-N-oxides ALTANA PHARMA AG (DE) 2003-10-07 US disclosed
WO-2003051861-A1 METHOD FOR THE PREPARATION OF ESCITALOPRAM H. LUNDBECK A/S (DK) 2003-06-26 WO disclosed
US-20030105123-A1 For therapy of respiratory system disorders ALTANA PHARMA AG (DE) 2003-06-05 US disclosed
US-6538005-B2 As inhibitors of phosphodiesterases; therapy ALTANA PHARMA AG (DE) 2003-03-25 US disclosed
US-6534519-B1 Phosphodiestease inhibitors are novel active bronchial therapeutics. ALTANA PHARMA AG (DE) 2003-03-18 US disclosed
US-6534518-B1 Phosphodiesterase inhibitors for respiratory system disorders ALTANA PHARMA AG (DE) 2003-03-18 US disclosed
EP-0872467-B1 Process for the production of chiral unsaturated alcohols in high optical purity EASTMAN CHEM CO (US) 2003-01-22 EP disclosed
US-20020183350-A1 Phenanthridine-n-oxides with pde-iv inhibiting activity GUTTERER BEATE (DE) 2002-12-05 US disclosed
US-6479505-B1 TREATING AIRWAY DISORDER IN A PATIENT COMPRISING ADMINISTERING TO SAID PATIENT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A PHOSPHODIESTERASE IV INHIBITOR ALTANA PHARMA AG (DE) 2002-11-12 US disclosed
US-6476025-B1 Phenylphennanthridines with PDE-IV inhibiting activity ALTANA PHARMA AG (DE) 2002-11-05 US disclosed
US-6414049-B1 SILICONE, ACYLPHOSPHINE PROMOTER, ACID MIXTURE JOHNSON & JOHNSON VISION CARE, INC. 2002-07-02 US disclosed
WO-2002006238-A1 CYCLOALKYL - OR CYCLOALKYLMETHYL-SUBSTITUTED 6-PHENYLPHENANTHRIDINES ALTANA PHARMA AG (DE) 2002-01-24 WO disclosed
EP-0754696-B1 Unsymmetric diphosphine monoxide compounds and a process for preparing diphosphine compounds TAKASAGO PERFUMERY CO LTD (JP) 2002-01-16 EP disclosed
US-6162943-A BY REACTING A KETO ESTER WITH TRIFLUOROMETHYLTRIMETHYL SILANE TO FORM A-TRIMETHYLSILOXY-A-TRIFLUOROMETHYL ARYL ACETIC ESTER; REACTING WITH ALKOXIDE TO FORM METAL SALT, AND ALKYLATING; REAGENT FOR DETERMINING OPTICAL PURITY OF AMINES BAYER AKTIENGESELLSCHAFT (DE) 2000-12-19 US disclosed
US-6093345-A PYRIMIDINE COMPOUNDS, ELECTROOPTICS TAKASAGO INTERNATIONAL CORPORATION (JP) 2000-07-25 US disclosed
EP-0993436-A1 (S) 2-METHYLAMINO-2-PHENYL-$i(n)-BUTYL 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN PARKE-DAVIS (FR) 2000-04-19 EP disclosed
US-5968938-A Piperazine oxytocin receptor antagonists MERCK & CO., INC. (US) 1999-10-19 US disclosed
US-5886214-A CATALYTIC ASYMMETRIC HYDROGENATION OF ENOL ESTERS BEARING A VINYLLIC OR AN ACETYLENIC SUBSTITUENT BY USING A CHIRAL RHODIUM(I) HYDROGENATION CATALYST PREPARED FROM A SUITABLE RHODIUM SALT AND AN OPTICALLY PURE PHOSPHINE LIGAND EASTMAN CHEMICAL COMPANY (US) 1999-03-23 US disclosed
WO-1999001417-A1 (S) 2-METHYLAMINO-2-PHENYL-n-BUTYL 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN PARKE-DAVIS (FR) 1999-01-14 WO disclosed
EP-0872467-A1 Process for the production of chiral unsaturated alcohols in high optical purity EASTMAN CHEMICAL COMPANY (US) 1998-10-21 EP disclosed
US-5808162-A Chiral unsymmetric diphosphine compound and transition metal complex containing the same as ligand TAKASAGO INTERNATIONAL CORPORATION (JP) 1998-09-15 US disclosed
US-5712388-A Method of preparing a derivative of optically active azetidin-2-one TAKASAGO INTERNATIONAL CORPORATION (JP) 1998-01-27 US disclosed
EP-0788472-A1 A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES CHIESI FARMACEUTICI S.p.A. (IT) 1997-08-13 EP disclosed
EP-0754696-A1 Chiral unsymmetric diphosphine compounds and transition metal complexes containing them as ligands Takasago International Corporation (JP) 1997-01-22 EP disclosed
EP-0427168-B1 Optical isomer of triazolylpentenols, and their production and use as fungicide, herbicide and/or plant growth regulant SUMITOMO CHEMICAL CO (JP) 1996-03-13 EP disclosed
EP-0255379-B1 Optically active alcohols, process for producing the same, and process for resolving the same NISSAN CHEMICAL IND LTD (JP) 1995-11-15 EP disclosed
WO-1995029147-A1 A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 1995-11-02 WO disclosed
US-5454976-A Optical active mixture comprising a fluoro-alkyl phenyl pyrimidine compounds; high contrast ratio, fast response time; optical switches, printer shutter arrays TAKASAGO INTERNATIONAL CORPORATION (JP) 1995-10-03 US disclosed
US-5428171-A Leukotrienes antagonist; antiasthmatic, antiallergic, anti-inflammatory and cytoprotective agent MERCK FROSST CANADA, INC. (CA) 1995-06-27 US disclosed
US-5348980-A Antihistamines, antiallergens INSTITUTE DE RECHERCHE JOUVEINAL (FR) 1994-09-20 US disclosed
US-5344936-A Selenocarbonyloxazolidinone UNIVERSITY OF SOUTH CAROLINA (US) 1994-09-06 US disclosed
US-5342780-A Methods of enzymatically separating stereoisomers of a racemic mixture of a reactive ester UNIVERSITY OF NEW MEXICO (US) 1994-08-30 US disclosed
EP-0354068-B1 Optically active piperazine derivative NIPPON CHEMIPHAR CO (JP) 1994-06-15 EP disclosed
US-5175378-A Synthesis of optically pure forms of ipsdienol ALDRICH CHEMICAL COMPANY, INC. (US) 1992-12-29 US disclosed
US-5175371-A Synthesis of optically pure forms of ipsenol ALDRICH CHEMICAL COMPANY, INC. (US) 1992-12-29 US disclosed
US-5136034-A Reacting an arylaldehyde with mercaptan and thioacyl in presence of acid catalysts; then reacting with electrophile MERCK FROSST CANADA, INC. (CA) 1992-08-04 US disclosed
US-5122472-A Selenocarbonyl compound as coupler in determination of enantiomeric purity UNIVERSITY OF SOUTH CAROLINA (US) 1992-06-16 US disclosed
US-5103063-A Intermediates useful for the chiral isoprenylation of aldehydes ALDRICH CHEMICAL COMPANY, INC. (US) 1992-04-07 US disclosed
EP-0121284-B1 (+)-TRIAZOLYLPENTENOL DERIVATIVE, ITS PRODUCTION AND USE AS HERBICIDE AND/OR PLANT GROWTH REGULANT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-11 EP disclosed
US-5075488-A Fungicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-12-24 US disclosed
EP-0128006-B1 A SOIL-DISEASE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-09-18 EP disclosed
US-5041559-A Having epoxy and silyl groups NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-08-20 US disclosed
US-5037855-A Silane group containing, chemical intermediates NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-08-06 US disclosed
EP-0427168-A1 Optical isomer of triazolylpentenols, and their production and use as fungicide, herbicide and/or plant growth regulant SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-05-15 EP disclosed
EP-0421774-A2 Process for production of optically active 2-(tetrahydropyran-2-yloxy)-1-propanol Takasago International Corporation (JP) 1991-04-10 EP disclosed
US-4987236-A STEREOSPECIFIC EPOXIDATION, RESOLUTION OF RACEMIC MIXTURES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-01-22 US disclosed
US-4978666-A INCREASED CEREBRAL CIRCULATION; ANTICOAGULANTS NIPPON CHEMIPHAR CO., LTD. (JP) 1990-12-18 US disclosed
US-4954625-A ENZYME INHIBITORS, HYPOTENSIVE AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-09-04 US disclosed
US-4902812-A Optically active alcohols, process for producing the same, and process for resolving the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1990-02-20 US disclosed
US-4871842-A Piperidine derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-10-03 US disclosed
US-4851409-A LEUKOTRIENE ANTAGONIST, ANTIASTHMA, ANTIALLERGEN, ANTIINFLAMMATORY, CYTOPROTECTIVE MERCK FROSST CANADA INC. (CA) 1989-07-25 US disclosed
US-4816466-A HYPOTENSIVE AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-03-28 US disclosed
US-4730065-A BRONCHODILATORS, HYPOTENSIVES, ANTISECRETORY AMERICAN CYANAMID COMPANY (US) 1988-03-08 US disclosed
EP-0255379-A2 Optically active alcohols, process for producing the same, and process for resolving the same NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1988-02-03 EP disclosed
EP-0233763-A2 2-Substituted quinoline dioic acids MERCK FROSST CANADA INC. (CA) 1987-08-26 EP disclosed
EP-0054431-B1 OPTICAL ISOMER OF A TRIAZOLYLPENTENOL, AND ITS PRODUCTION AND USE AS FUNGICIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-03-04 EP disclosed
EP-0187037-A2 Piperidine derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1986-07-09 EP disclosed
EP-0175278-A2 Optical isomer of triazolylpentenols, and their production and use as fungicide herbicide and/or plant growth regulant SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-03-26 EP disclosed
US-4518790-A 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners AMERICAN CYANAMID COMPANY (US) 1985-05-21 US disclosed
US-4504417-A 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners AMERICAN CYANAMID COMPANY (US) 1985-03-12 US disclosed
EP-0128006-A2 A soil-disease-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-12 EP disclosed
EP-0121284-A2 (+)-Triazolylpentenol derivative, its production and use as herbicide and/or plant growth regulant SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-10-10 EP disclosed
US-4473502-A Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid MERCK & CO., INC. (US) 1984-09-25 US disclosed
US-4467107-A INTERMEDIATES FOR THIENAMYCIN MERCK & CO., INC. (US) 1984-08-21 US disclosed
US-4448721-A Hydroxyvitamin D2 compounds and process for preparing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1984-05-15 US disclosed
US-4435203-A 1-(4-CHLORO- OR 2,4-DICHLORO-PHENYL)-2-(1,2,4-TRIAZOL-1-YL)-4,4-DIMETHYLPENT-1-EN-3-OL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-03-06 US disclosed
US-4429148-A PROSTAGLANDINS; BRONCHODILATORS, HYPTOTENSIVES AMERICAN CYANAMID COMPANY (US) 1984-01-31 US disclosed
US-4415746-A BRONCHODILATORS; HYPOTENSIVE AND ANTIFERTILITY AGENTS; OXYTOCICS AMERICAN CYANAMID COMPANY (US) 1983-11-15 US disclosed
US-4414155-A Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid MERCK & CO., INC. (US) 1983-11-08 US disclosed
EP-0087319-A1 R- and S-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine SMITHKLINE BECKMAN CORPORATION (US) 1983-08-31 EP disclosed
US-4387241-A BRONCHODILATORS, HYPOTENSIVE AGENTS, AND CONTRACEPTIVES AMERICAN CYANAMID COMPANY (US) 1983-06-07 US disclosed
US-4358605-A BRONCHODILATORS, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1982-11-09 US disclosed
US-4349687-A Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid MERCK & CO., INC. (US) 1982-09-14 US disclosed
EP-0054431-A1 Optical isomer of a triazolylpentenol, and its production and use as fungicide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1982-06-23 EP disclosed
US-4334077-A Stereospecific sulfoxidation of dibenzo thiepins MERCK & CO., INC. (US) 1982-06-08 US disclosed
US-4328358-A ENANTIOMORPHS USEFUL AS BRONCHODILATORS, HYPOTENSIVE AGENTS OR GASTRIC ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1982-05-04 US disclosed
US-4321405-A HYPOTENSIVE AGENTS, BRONCHODILATORS, ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1982-03-23 US disclosed
US-4287123-A Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate MERCK & CO., INC. (US) 1981-09-01 US disclosed
US-4282148-A Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid MERCK & CO., INC. (US) 1981-08-04 US disclosed
US-4281153-A USEFUL AS BRONCHODILATORS, HYPOTENSIVE AGENTS AND AGENTS FOR THE CONTROL OF GASTRIC SECRETION AMERICAN CYANAMID (US) 1981-07-28 US disclosed
EP-0032400-A1 (3SR, 4RS)-3-((RS)-1-hydroxyethyl)- and -((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same MERCK & CO. INC. (US) 1981-07-22 EP disclosed
US-4245121-A HAVING A TERMINAL CYCLIC MOIETY IN THE B-CHAIN AMERICAN CYANAMID COMPANY (US) 1981-01-13 US disclosed
US-4243817-A TERMINAL CYCLIC MOIETY IN THE B-CHAIN; PROSTOGLANDIN ACTIVITY AMERICAN CYANAMID COMPANY (US) 1981-01-06 US disclosed
US-4239900-A BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-12-16 US disclosed
US-4239899-A BRONCHODILATORS, HYPOTENSIVE, GASTRIC ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-12-16 US disclosed
US-4228296-A PROSTAGLANDINS AMERICAN CYANAMID COMPANY (US) 1980-10-14 US disclosed
US-4219664-A BRONCHODILATORS, HYPOTENSIVE AGENTS, GASTRIC ACID SECRETION INHIBITORS AMERICAN CYANAMID COMPANY (US) 1980-08-26 US disclosed
US-4202989-A BRONCHODILATORS, HYPOTENSIVE AGENTS ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-05-13 US disclosed
US-4202988-A Prostenoic acids and esters AMERICAN CYANAMID COMPANY (US) 1980-05-13 US disclosed
US-4198521-A BRONCHODILATOR, HYPOTENSIVE, AND ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-04-15 US disclosed
US-4197407-A PROSTAGLANDINS AMERICAN CYANAMID COMPANY (US) 1980-04-08 US disclosed
US-4194055-A PROSTAGLANDINS, BRONCHODILATORS, ANTIINFLAMMATORY, HYPOTSENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1980-03-18 US disclosed
US-4192950-A BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTISECRETORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-03-11 US disclosed
US-4191699-A ANTISECRETORY, HYPOTENSIVE, BRONCHODILATOR AMERICAN CYANAMID COMPANY (US) 1980-03-04 US disclosed
US-4190597-A BRONCHODILATORS, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1980-02-26 US disclosed
US-4190596-A BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTISECRETORY, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1980-02-26 US disclosed
US-4179451-A HYPOTENSIVE, ANTIULCER, BRONCHODILATOR, ANTICONVULSANTS OR ANTIMICROBIAL AGENTS AMERICAN CYANAMID COMPANY (US) 1979-12-18 US disclosed
US-4178456-A PROSTAGLANDINS AMERICAN CYANAMID COMPANY (US) 1979-12-11 US disclosed
US-4178461-A BRONCHODILATORS, GASTRIC ACID SECRETION INHIBITORS AMERICAN CYANAMID COMPANY (US) 1979-12-11 US disclosed
US-4152524-A BRONCHODILATORS, HYPOTENSIVE AMERICAN CYANAMID COMPANY (US) 1979-05-01 US disclosed
US-4131737-A PROSTAGLANDINS AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed
US-4113967-A BRONCHODILATORS, HYPOTENSIVE, ANTISECRETORY AMERICAN CYANAMID COMPANY (US) 1978-09-12 US disclosed
US-4111959-A BRONCHODILATORS, ANTIINFLAMMATORY, HYPOTENSIVE, ANTISECRETORY AMERICAN CYANAMID COMPANY (US) 1978-09-05 US disclosed
US-4107441-A HYPOTENSIVE, ANTIULCER, BRONCHODILATORS, ANTIMICROBIAL, ANTICONVULSANTS AMERICAN CYANAMID COMPANY (US) 1978-08-15 US disclosed
US-4076947-A BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTIULCER AGENTS AMERICAN CYANAMID COMPANY (US) 1978-02-28 US disclosed
US-4061672-A Derivatives of 9-hydroxy-13-trans-prostenoic acid AMERICAN CYANAMID COMPANY (US) 1977-12-06 US disclosed
US-4061670-A BRONCHODILATOR, HYPOTENSIVE, ANTISECRETORY AMERICAN CYANAMID COMPANY (US) 1977-12-06 US disclosed
US-RE29469-E PROSTAGLANDINS; BRONCHODILATORS, HYPOTENSIVES, ANTIULCER AGENTS AMERICAN CYANAMID COMPANY (US) 1977-11-08 US disclosed
US-4054604-A MICROBIOCIDES, HYPOTENSIVE AGENTS AMERICAN CYANAMID COMPANY (US) 1977-10-18 US disclosed
US-4044043-A HYPERTENSIVE AGENTS, MICROBIOCIDES AMERICAN CYANAMID COMPANY (US) 1977-08-23 US disclosed
US-4039574-A 13-Hydroxy-15-deoxy-prostaglandins AMERICAN CYANAMID COMPANY (US) 1977-08-02 US disclosed
US-4028396-A BRONCHODILATORS, GASTRIC ACID SECRETION INHIBITORS AMERICAN CYANAMID COMPANY (US) 1977-06-07 US disclosed
US-3981868-A MICROBIOCIDES, HYPOTENSIVE AGENTS AMERICAN CYANAMID COMPANY (US) 1976-09-21 US disclosed
US-3950406-A BRONCHODILATORS, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1976-04-13 US disclosed
US-3932463-A BRONCHODILATORS, GASTRIC ACID SECRETION INHIBITORS AMERICAN CYANAMID COMPANY (US) 1976-01-13 US disclosed
US-3932463-A BRONCHODILATORS, GASTRIC ACID SECRETION INHIBITORS AMERICAN CYANAMID COMPANY (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10421737-B2 Process for the preparation of optically active Beraprost CYP51A1, DDOST, SQLE PDPK1 1916/4885PPARG 3219/4885PPARA 2423/4885
US-20200231562-A1 NOVEL MACROLIDE ANTIBIOTICS MRPL21, MRPS18A, LSS PDPK1 3428/4885PPARG 1561/4885PPARA 1997/4885
US-20150352096-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE12 PDPK1 293/4885PPARG 937/4885PPARA 2094/4885
US-20080119505-A1 Novel 6-Pyridylphenanthridines PDE4A, PDE4B, PDE4C PDPK1 479/4885PPARG 1583/4885PPARA 2835/4885
US-20030105123-A1 For therapy of respiratory system disorders CHRM3, CYP11B1, CYP11B2 PDPK1 4295/4885PPARG 737/4885PPARA 2066/4885
US-20110077404-A1 PROCESS FOR PREPARING ENANTIOMERICALLY PURE INDOLOPYRIDINES GRIK5, CYP3A5, GRK5 PDPK1 545/4885PPARG 3029/4885PPARA 4559/4885
US-20120083527-A1 Anticancer Agents TP53, HCCS, RB1 PDPK1 631/4885PPARG 1164/4885PPARA 947/4885
US-20110027226-A1 INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) KIF5A, KIF5C, KIF5B PDPK1 277/4885PPARG 4306/4885PPARA 4708/4885
US-10259779-B2 Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity HDAC8, HDAC6, HDAC1 PDPK1 3515/4885PPARG 1619/4885PPARA 1866/4885
US-20140073636-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE12 PDPK1 293/4885PPARG 937/4885PPARA 2094/4885
US-20130045974-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C PDPK1 89/4885PPARG 200/4885PPARA 723/4885
US-20200102275-A1 CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST AGTR2, AGTR1, HCAR2 PDPK1 2700/4885PPARG 232/4885PPARA 294/4885
US-20100285149-A1 NOVEL TETRAHYDROPYRIDOTHIOPHENES BAX, CCAR2, BCL2 PDPK1 1812/4885PPARG 2394/4885PPARA 3416/4885
US-11021445-B2 Carboxylic acid derivative as AT2R receptor antagonist AGTR2, AGTR1, HCAR2 PDPK1 2700/4885PPARG 232/4885PPARA 294/4885
US-20060142376-A1 Method for obtaining an antiepileptic agent VKORC1, EPM2A, HNMT PDPK1 2767/4885PPARG 3967/4885PPARA 3522/4885
US-20180057448-A1 Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity HDAC8, HDAC6, HDAC1 PDPK1 3515/4885PPARG 1619/4885PPARA 1866/4885
US-20110257221-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C PDPK1 206/4885PPARG 529/4885PPARA 1691/4885
US-20110213149-A1 PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF BPNT1, GART, SLC7A1 PDPK1 3877/4885PPARG 3145/4885PPARA 2266/4885
US-20080167316-A1 6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders PDE4A, PDE4B, PDE4C PDPK1 1753/4885PPARG 960/4885PPARA 1867/4885
US-20130165648-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES HTR3C, HTR3B, HTR3A PDPK1 903/4885PPARG 555/4885PPARA 983/4885
US-11168249-B1 Luminescent polydentate polycyclic compounds for metal ions PCBP1, CACYBP, CA9 PDPK1 185/4885PPARG 3850/4885PPARA 2177/4885
US-10125074-B2 5-substituted-5-hydroxy-5-aryl-3-oxo-pentanoate derivatives and their enantiopure forms ADH5, ADH1A, ADH1C PDPK1 2553/4885PPARG 389/4885PPARA 137/4885
US-20090258904-A1 Epithiolone Analogues ESRRB, ESR2, ESRRA PDPK1 3601/4885PPARG 518/4885PPARA 399/4885
US-20150119389-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C PDPK1 89/4885PPARG 200/4885PPARA 723/4885
US-20080161339-A1 Novel Thio-Containing Hydroxy-6-Phenylphenanthridines and their Use as Pde4 Inhibitors PDE4A, PDE4B, PDE4C PDPK1 326/4885PPARG 686/4885PPARA 1953/4885
US-20160185729-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES HTR3C, HTR3B, HTR3A PDPK1 903/4885PPARG 555/4885PPARA 983/4885
US-20110257169-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C PDPK1 206/4885PPARG 529/4885PPARA 1691/4885
US-20060189645-A1 Novel 6-phenylphenantridines PDE4B, PDE4A, PDE4D PDPK1 426/4885PPARG 2502/4885PPARA 3651/4885
US-20130178620-A1 PROCESSES FOR PREPARING 3-BENZAZEPINES HTR3C, HTR3B, HTR3A PDPK1 903/4885PPARG 555/4885PPARA 983/4885
US-20050239817-A1 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors PDE4A, PDE4B, PDE3A PDPK1 215/4885PPARG 1879/4885PPARA 3062/4885
US-20070185149-A1 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors PDE4A, PDE4B, PDE4C PDPK1 573/4885PPARG 607/4885PPARA 1335/4885
US-20160279120-A1 NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS PDE4A, PDE12, PDE4B PDPK1 345/4885PPARG 123/4885PPARA 303/4885
US-20070259909-A1 Novel Difluoroethoxy-Substituted Hydroxy-6-Phenylphenanthridines and Their Use as Pde4 Inhibitors PDE4A, PDE4B, PDE4D PDPK1 207/4885PPARG 496/4885PPARA 1384/4885
US-20070167482-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors PDE4A, PDE3A, PDE4B PDPK1 686/4885PPARG 1638/4885PPARA 3577/4885
US-20180118648-A1 5-SUBSTITUTED-5-HYDROXY-5-ARYL-3-OXO-PENTANOATE DERIVATIVES AND THEIR ENANTIOPURE FORMS ADH5, ADH1A, ADH1C PDPK1 2553/4885PPARG 389/4885PPARA 137/4885
US-20090233902-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS KIF5A, KIF5C, KIF5B PDPK1 165/4885PPARG 2548/4885PPARA 4179/4885
US-20040038979-A1 Treating airway disorders such as asthma. PTGER4, PDE4B, PDE4A PDPK1 2593/4885PPARG 1202/4885PPARA 1881/4885
US-20050154051-A1 Method for the preparation of escitalopram SLC6A4, TPH2, SLC6A3 PDPK1 4222/4885PPARG 3882/4885PPARA 4312/4885
US-20080167301-A1 Respiratory system disorders PDE4A, PDE4B, PDE12 PDPK1 735/4885PPARG 427/4885PPARA 1001/4885
US-20080319067-A1 2-Hydroxy-6-phenylphenanthridines as PDE-4 inhibitors PDE4A, PDE4B, PDE3A PDPK1 215/4885PPARG 1879/4885PPARA 3062/4885
US-20100035913-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiestrase (PDE) 4 inhibitors PDE4A, PDE4B, PDE4C PDPK1 540/4885PPARG 2268/4885PPARA 3715/4885
US-20020183350-A1 Phenanthridine-n-oxides with pde-iv inhibiting activity PDE3A, PDE3B, PDE4A PDPK1 1214/4885PPARG 2466/4885PPARA 3241/4885
US-20050239818-A1 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors PDE4A, PDE4B, PDE3A PDPK1 221/4885PPARG 1857/4885PPARA 3036/4885
US-20080214536-A1 Amido-Substituted 6-Phenylphenanthridines PDE4A, PDE4B, PDE3A PDPK1 477/4885PPARG 1617/4885PPARA 2154/4885
US-20090170892-A1 3-Hydroxy-6-phenylphenanthridines as pde4 inhibitors PDE4A, PDE4B, PDE3A PDPK1 322/4885PPARG 2343/4885PPARA 3500/4885
US-20060116518-A1 Novel phenanthridines PDE4A, PDE4B, PDE3A PDPK1 448/4885PPARG 3183/4885PPARA 3777/4885
US-10633586-B1 Luminescent polydentate polycyclic compounds for metal ions PCBP1, CACYBP, CA9 PDPK1 185/4885PPARG 3850/4885PPARA 2177/4885
US-20070191414-A1 Novel isoamido-substituted hydroxy-6-phenylphenanthridines PDE4A, PDE4B, PDE4C PDPK1 346/4885PPARG 554/4885PPARA 1946/4885
US-20100104659-A1 BENZOPYRANOPYRAZOLES BAX, BCL2, BAD PDPK1 1209/4885PPARG 287/4885PPARA 630/4885
US-20090246169-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS KIF5A, KIF5C, KIF5B PDPK1 165/4885PPARG 2548/4885PPARA 4179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.