Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.48 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840304 | 0.98 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1RARBHTTFFAR1 | |
| Hydrochloric Acid SCHEMBL711176 | 0.95 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1HTTFFAR1NPC1 | |
| SCHEMBL1489146 | 0.93 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1HTTFFAR1NPC1 | |
| Biphenyl SCHEMBL5095997 | 0.92 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1RARBHTTFFAR1 | |
| Benzene SCHEMBL28158854 | 0.91 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1HTTFFAR1NPC1 | |
| Benzoic Acid SCHEMBL9750866 | 0.90 | FFAR1 (0.55) | ALDH1A1L3MBTL1RARBHTTFFAR1 | |
| Hydroquinone SCHEMBL7626940 | 0.87 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1HTTFFAR1NPC1 | |
| Hydroquinone SCHEMBL8024416 | 0.87 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1HTTFFAR1NPC1 | |
| SCHEMBL7357344 | 0.86 | NR1H4 (0.63) | ALDH1A1L3MBTL1RARBHTTFFAR1 | |
| Hydrochloric Acid SCHEMBL8861914 | 0.86 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1HTTFFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3123759-A | — | — | None | — | — | JP | disclosed |
| JP-5186401-A | — | — | None | — | — | JP | disclosed |
| JP-6192198-A | — | — | None | — | — | JP | disclosed |
| EP-0571277-B1 | Antiferroelectric liquid crystal compound | SHOWA SHELL SEKIYU (JP) | 1996-06-26 | — | — | EP | disclosed |
| EP-0422996-B1 | Liquid crystal compound | SHOWA SHELL SEKIYU (JP) | 1995-04-12 | — | — | EP | disclosed |
| EP-0466573-B1 | Liquid crystal compositions | SHOWA SHELL SEKIYU (JP) | 1995-02-15 | — | — | EP | disclosed |
| US-5364561-A | Diluent; optically tristable; electrooptics | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1994-11-15 | — | — | US | disclosed |
| US-5328641-A | Naphthalene ester derivatives with trifluoromethyl groups | SHOWA SHELL SEKIYU KABUSHIKI KAISHA | 1994-07-12 | — | — | US | disclosed |
| JP-H06192198-A | LIQUID CRYSTAL COMPOUND | SHOWA SHELL SEKIYU KK | 1994-07-12 | — | — | JP | disclosed |
| US-5320776-A | Antiferroelectric liquid crystal compound | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0571277-A1 | Antiferroelectric liquid crystal compound | Showa Shell Sekiyu Kabushiki Kaisha (JP) | 1993-11-24 | — | — | EP | disclosed |
| JP-H05186401-A | LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME | SHOWA SHELL SEKIYU KK | 1993-07-27 | — | — | JP | disclosed |
| US-5207947-A | Trifluoroalkyl diaryl triesters; antiferroelectricity; electrooptics | SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0466573-A2 | Liquid crystal compositions | Showa Shell Sekiyu Kabushiki Kaisha (JP) | 1992-01-15 | — | — | EP | disclosed |
| JP-H03123759-A | LIQUID CRYSTAL COMPOUND | SHOWA SHELL SEKIYU KK | 1991-05-27 | — | — | JP | disclosed |
| US-4820444-A | SUPERIOR FERROELECTRIC MATERIAL | CHISSO CORPORATION (JP) | 1989-04-11 | — | — | US | disclosed |
| EP-0115693-B1 | LIQUID CRYSTALLINE COMPOUNDS AND MIXTURES THEREOF | Chisso Corporation (JP) | 1987-08-26 | — | — | EP | disclosed |
| US-4596667-A | Phenyl ester derivatives | CHISSO CORPORATION (JP) | 1986-06-24 | — | — | US | disclosed |
| EP-0115693-A2 | Liquid crystalline compounds and mixtures thereof | Chisso Corporation (JP) | 1984-08-15 | — | — | EP | disclosed |