Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.50 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.35 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SELL | P14151 | 1/20 | 0.35 |
| ▸ | SELP | P16109 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27979336 | 1.00 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL5028438 | 0.97 | ALDH1A1 (0.52) | ALDH1A1GAAMAPTKDM4ELMNA | |
| Benzene SCHEMBL28239798 | 0.92 | ALDH1A1 (0.48) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL28575233 | 0.86 | ALDH1A1 (0.48) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL19730667 | 0.83 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKDM4ELMNA | |
| Cystamine SCHEMBL28068510 | 0.81 | MAPT (0.42) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL9500782 | 0.79 | TRPA1 (0.46) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL3618414 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL12127221 | 0.78 | ALDH1A1 (0.52) | ALDH1A1GAAMAPTKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL5162607 | 0.78 | PTK2 (0.47) | ALDH1A1GAAMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107417918-B | Cross-linkable PBO copolymer and preparation method and application thereof | 郑州大学 | 2022-03-01 | — | — | CN | claimed |
| CN-105504270-B | The preparation method of crosslinked polyphenylene Benzo-dioxazole film | 郑州大学 | 2018-06-08 | — | — | CN | claimed |
| CN-106810696-A | Cross-linking poly- alkylene Benzo-dioxazole and preparation method thereof | 郑州大学 | 2017-06-09 | — | — | CN | claimed |
| CN-103980133-B | A kind of method preparing 2-methyl-4,6-diaminoresorcinol dihydrochloride | 郑州大学 | 2016-06-08 | — | — | CN | claimed |
| CN-105504270-A | Preparation method of crosslinking poly(p-phenylenebenzobisoxazole) film | UNIV ZHENGZHOU | 2016-04-20 | — | — | CN | claimed |
| CN-103980133-A | Method for preparing 2-methyl-4,6-diaminoresorcinol hydrochloride | UNIV ZHENGZHOU | 2014-08-13 | — | — | CN | claimed |
| CN-107417918-B | Cross-linkable PBO copolymer and preparation method and application thereof | 郑州大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-107417918-B | Cross-linkable PBO copolymer and preparation method and application thereof | 郑州大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-105504270-B | The preparation method of crosslinked polyphenylene Benzo-dioxazole film | 郑州大学 | 2018-06-08 | — | — | CN | disclosed |
| CN-107417918-A | Cross-linking PBO copolymers and its production and use | 郑州大学 | 2017-12-01 | — | — | CN | disclosed |
| CN-106810696-A | Cross-linking poly- alkylene Benzo-dioxazole and preparation method thereof | 郑州大学 | 2017-06-09 | — | — | CN | disclosed |
| CN-103980133-B | A kind of method preparing 2-methyl-4,6-diaminoresorcinol dihydrochloride | 郑州大学 | 2016-06-08 | — | — | CN | disclosed |
| CN-103980133-B | A kind of method preparing 2-methyl-4,6-diaminoresorcinol dihydrochloride | 郑州大学 | 2016-06-08 | — | — | CN | disclosed |
| US-5021580-A | Monomer containing aromatic group, two amine, two hydroxy, and a methyl groups | THE DOW CHEMICAL COMPANY (US) | 1991-06-04 | — | — | US | disclosed |
| US-4982001-A | Process for the preparation of amino-1,3-benzenediol | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0392008-A1 | COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES | THE DOW CHEMICAL COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |
| EP-0368006-A2 | Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties | THE DOW CHEMICAL COMPANY (US) | 1990-05-16 | — | — | EP | disclosed |
| WO-1990003995-A1 | COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES | THE DOW CHEMICAL COMPANY (US) | 1990-04-19 | — | — | WO | disclosed |
| US-4912246-A | 1,3-bis(alkylcarbonato)-nitrobenzenes | THE DOW CHEMICAL COMPANY (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0312931-A2 | Process for the preparation of amino-1,3 benzenediol | THE DOW CHEMICAL COMPANY (US) | 1989-04-26 | — | — | EP | disclosed |