Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK known ✓ | P06239 | 1/20 | 0.40 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADH1B | P00325 | 1/20 | 0.43 |
| ▸ | ADH1C | P00326 | 1/20 | 0.43 |
| ▸ | ADH1A | P07327 | 1/20 | 0.43 |
| ▸ | ADH4 | P08319 | 1/20 | 0.43 |
| ▸ | ADH7 | P40394 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 3/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965573 | 0.97 | TSHR (0.65) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL965056 | 0.97 | TSHR (0.65) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL965893 | 0.97 | TSHR (0.65) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL10411852 | 0.95 | ALDH1A1 (0.70) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL9361148 | 0.95 | ALDH1A1 (0.70) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL15057305 | 0.93 | ALDH1A1 (0.60) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL16236848 | 0.93 | ALDH1A1 (0.60) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL16237314 | 0.92 | ALDH1A1 (0.73) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL16236793 | 0.91 | ALDH1A1 (0.64) | TSHRALDH1A1CYP3A4LMNAADH1B | |
| SCHEMBL277614 | 0.90 | ALDH1A1 (0.62) | TSHRALDH1A1CYP3A4LMNAADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312992-B1 | HAIRDRESSING COMPOSITION | Kao Corporation (JP) | 1992-05-13 | — | — | EP | claimed |
| US-4910013-A | Branched alkyl quaternary ammonium salt | KAO CORPORATION (JP) | 1990-03-20 | — | — | US | claimed |
| EP-0312992-A2 | Hairdressing composition | Kao Corporation (JP) | 1989-04-26 | — | — | EP | claimed |
| EP-0392320-B1 | Shampoo composition | KAO CORP (JP) | 1995-07-05 | — | — | EP | disclosed |
| EP-0314141-B1 | Detergent composition | KAO CORP (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5211883-A | Amidoamine type amphoteric surfactant, a modified silicone and a specific polymer | KAO CORPORATION (JP) | 1993-05-18 | — | — | US | disclosed |
| EP-0242792-B1 | HAIR COSMETIC COMPOSITION | Kao Corporation (JP) | 1992-07-22 | — | — | EP | disclosed |
| EP-0312992-B1 | HAIRDRESSING COMPOSITION | Kao Corporation (JP) | 1992-05-13 | — | — | EP | disclosed |
| EP-0181547-B1 | HAIR COSMETIC COMPOSITION | Kao Corporation (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-5077041-A | Amidoamine amphoteric surfactant, modified silicone polymer, cationic polymer | KAO CORPORATION (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0392320-A2 | Shampoo composition | KAO CORPORATION (JP) | 1990-10-17 | — | — | EP | disclosed |
| US-4931216-A | HAIR CONDITIONING SHAMPOO; WASHING WOOL FIBERS | KAO CORPORATION (JP) | 1990-06-05 | — | — | US | disclosed |
| US-4910013-A | Branched alkyl quaternary ammonium salt | KAO CORPORATION (JP) | 1990-03-20 | — | — | US | disclosed |
| EP-0314141-A2 | Detergent composition | Kao Corporation (JP) | 1989-05-03 | — | — | EP | disclosed |
| EP-0312992-A2 | Hairdressing composition | Kao Corporation (JP) | 1989-04-26 | — | — | EP | disclosed |
| US-4711776-A | BRANCHED QUARTERNARY AMMONIUM SALT AND OIL OR FAT | KAO CORPORATION (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0242792-A2 | Hair cosmetic composition | Kao Corporation (JP) | 1987-10-28 | — | — | EP | disclosed |
| EP-0181547-A2 | Hair cosmetic composition | Kao Corporation (JP) | 1986-05-21 | — | — | EP | disclosed |