Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Flavone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 5/20 | 0.96 |
| ▸ | GABRD known ✓ | O14764 | 5/20 | 0.96 |
| ▸ | GABRA1 known ✓ | P14867 | 5/20 | 0.96 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 0.96 |
| ▸ | GABRG2 known ✓ | P18507 | 5/20 | 0.96 |
| ▸ | GABRB3 known ✓ | P28472 | 5/20 | 0.96 |
| ▸ | GABRA5 known ✓ | P31644 | 5/20 | 0.96 |
| ▸ | GABRA3 known ✓ | P34903 | 5/20 | 0.96 |
| ▸ | GABRA2 known ✓ | P47869 | 5/20 | 0.96 |
| ▸ | GABRB2 known ✓ | P47870 | 5/20 | 0.96 |
| ▸ | GABRA4 known ✓ | P48169 | 5/20 | 0.96 |
| ▸ | GABRE known ✓ | P78334 | 5/20 | 0.96 |
| ▸ | GABRA6 known ✓ | Q16445 | 5/20 | 0.96 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 5/20 | 0.96 |
| ▸ | GABRG3 known ✓ | Q99928 | 5/20 | 0.96 |
| ▸ | GABRQ known ✓ | Q9UN88 | 5/20 | 0.96 |
| ▸ | PARP1 known ✓ | P09874 | 4/20 | 0.96 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.96 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.96 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flavone SCHEMBL28612130 | 0.98 | TNKS (0.93) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL31316377 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL28248986 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL18879 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL30542161 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL15676601 | 0.98 | TNKS (1.00) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL3090011 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL6908621 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL8069086 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Flavone SCHEMBL31107308 | 0.96 | TNKS (0.96) | TNKSGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113730606-B | CYP1B1 enzyme-targeted NIR/PET bimodal probe precursor and preparation and application thereof | 上海交通大学 | 2022-06-28 | — | — | CN | disclosed |
| CN-112806567-A | Nutritional fat-reducing meal replacement powder containing plant extracts | 广东浠芮生物科技有限责任公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-112056459-A | Preparation method of garlic extract and composite natural plant extract additive thereof | 天津纳尔生物科技有限公司 | 2020-12-11 | — | — | CN | disclosed |
| CN-106986495-A | A kind of removable movable pot integrated sewage treating apparatus and its method of work | 徐州工程学院 | 2017-07-28 | — | — | CN | disclosed |
| CN-1193753-C | Ginkgo leaf extract and injection fluid containing same | GUO DONGYU (CN) | 2005-03-23 | — | — | CN | disclosed |
| CN-1481793-A | Ginkgo leaf extract and injection fluid containing same | 郭东宇 | 2004-03-17 | — | — | CN | disclosed |
| EP-0533804-A1 | SIGMA BINDING SITE AGENTS | GUILFORD PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991018597-A1 | SIGMA BINDING SITE AGENTS | ERICKSON RONALD H (US) | 1991-12-12 | — | — | WO | disclosed |
| US-5013852-A | Antiinflammatory | KALI-CHEMIE PHARMA GMBH (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0081621-A1 | Chromones | PENNWALT CORPORATION (US) | 1983-06-22 | — | — | EP | disclosed |
| EP-0064165-A1 | Antihypertensive agents | PENNWALT CORPORATION (US) | 1982-11-10 | — | — | EP | disclosed |